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  • SAGE Publications  (83)
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  • 1
    Online Resource
    Online Resource
    Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching
    SAGE Publications ; 2022
    In:  Journal of Endovascular Therapy Vol. 29, No. 1 ( 2022-02), p. 117-131
    Details
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 29, No. 1 ( 2022-02), p. 117-131
    Abstract: Smooth muscle cell (SMC) phenotypic switching is associated with development of a variety of occlusive vascular diseases. Paeonol has been reported to be involved in suppressing SMC proliferation. However, it is still unknown whether paeonol can regulate SMC phenotypic switching, and which eventually result in suppressing vasculogenesis. Methods: Murine left common carotid artery was injured by completely ligation, and paeonol was administrated by intraperitoneal injection. Hematoxylin and eosin (H & E) staining was performed to visualize vascular neointima formation. Rat aortic SMCs were used to determine whether paeonol suppresses cell proliferation and migration. And murine hind limb ischemia model was performed to confirm the function role of paeonol in suppressing vasculogenesis. Results: Complete ligation of murine common carotid artery successfully induced neointima formation. Paeonol treatment dramatically reduced the size of injury-induced neointima. Using rat aortic primary SMC, we identified that paeonol strongly suppressed cell proliferation, migration, and decreased extracellular matrix deposition. And paeonol treatment dramatically suppressed vasculogenesis after hind limb ischemia injury. Conclusion: Paeonol could regulate SMC phenotypic switching through inhibiting proliferation and migration of SMC, which results in inhibiting ischemia-induced vasculogenesis.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    URL: Article
    DOI: 10.1177/15266028211032956
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2049858-5
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  • 2
    Online Resource
    Online Resource
    Utility of T2 mapping in the staging of thyroid-associated ophthalmopathy: efficiency of region of interest selection methods
    SAGE Publications ; 2020
    In:  Acta Radiologica Vol. 61, No. 11 ( 2020-11), p. 1512-1519
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 61, No. 11 ( 2020-11), p. 1512-1519
    Abstract: Discriminating the stage of thyroid-associated ophthalmopathy (TAO) is crucial for the treatment strategy and prognosis prediction. Utility of conventional magnetic resonance imaging in the disease staging is limited. Purpose To investigate the performance of T2 mapping based on different region of interest (ROI) selection methods in the staging of TAO. Material and Methods Thirty-two patients with TAO were retrospectively enrolled. Two radiologists independently measured the T2 relaxation time (T2RT) of extraocular muscles using two different ROIs (hotspot [ROI HS ]: T2RT-hot; single-slice [ROI SS ]: T2RT-mean, T2RT-max, T2RT-min). Independent-samples t test, Wilcoxon signed rank test, Spearman correlation analysis, receiver operating characteristic (ROC) curves analyses, multiple ROC comparisons, and intra-class correlation coefficient (ICC) were used for statistical analyses. Results No significant difference was found in the measuring time between ROI HS and ROI SS methods ( P = 0.066). T2RT-mean demonstrated the highest ICC for measurement, followed by T2RT-max and T2RT-min, and T2RT-hot showed the poorest reproducibility. Active TAOs showed significantly higher values for all the T2RTs than inactive mimics (all P  〈  0.001). Significant positive correlations were found between T2RTs and CAS (all P  〈  0.005). T2RT-hot and T2RT-max showed significantly higher areas under the curve than that of T2RT-mean ( P = 0.013 and 0.024, respectively), while the difference between T2RT-hot and T2RT-max was not significant ( P = 0.970). Conclusion The T2RTs derived from both ROI selection methods could be useful for the staging of TAO. The results of measuring time, reproducibility, and diagnostic performance suggest that T2RT-max would be the optimal indicator for staging.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185120905032
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024579-8
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  • 3
    Online Resource
    Online Resource
    Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 6 ( 2020-06), p. 030006052092787-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 6 ( 2020-06), p. 030006052092787-
    Abstract: To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients. Methods This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and outcomes. Sputum samples from all patients were collected and assessed for the presence of yeast or fungi. Cryptococcal antigen testing was performed for some patients. Histopathological analysis was also undertaken for some samples of lung tissue. Results The study analysed 37 patients (22 males). Thirteen (35.14%) patients were asymptomatic, 24 (64.86%) were symptomatic and 17 (45.95%) patients had no underlying disease. Out of 25 tested patients, 23 (92.00%) tested positive on the serum cryptococcal capsular polysaccharide antigen test. During 6 to 24 months of follow-up, all 37 patients that were either treated with or without antifungal therapy alone or combined with surgical resection showed complete recovery. One patient made a full recovery without any treatment. Conclusion Early identification of pulmonary cryptococcosis in HIV-negative patients and timely detection of cryptococcal antigens in serum or respiratory specimens may help to improve diagnosis, prognosis and treatment of the disease.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520927877
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 4
    Online Resource
    Online Resource
    Is statin therapy after ischaemic stroke associated with increased intracerebral hemorrhage? The association may be dependent on intensity of statin therapy
    SAGE Publications ; 2023
    In:  International Journal of Stroke Vol. 18, No. 8 ( 2023-10), p. 948-956
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 18, No. 8 ( 2023-10), p. 948-956
    Abstract: There has been concern that statin therapy may be associated with an increased risk of intracerebral hemorrhage (ICH). We investigated whether the intensity and type of statin therapy instituted after ischemic stroke (IS) were associated with risk of future ICH in a region of northern China with a high incidence of stroke. Methods: Newly diagnosed IS patients who were not treated with lipid-lowering drugs in the Beijing Employee Medical Claims Data database from 2010 to 2017 were included. The primary exposure variable was any statin prescription within 1 month of the first documented stroke diagnosis. High-intensity statin therapy was defined as atorvastatin ⩾ 80 mg, simvastatin ⩾ 80 mg, pravastatin ⩾ 40 mg, and rosuvastatin ⩾ 20 mg per day or equivalent combination. An adjusted Cox proportional hazards model was used to estimate the hazard ratio (HR) for ICH during follow-up in groups exposed and not exposed to statins. Results: Of 62,252 participants with IS and 628 ICH readmissions were recorded during a median follow-up of 3.17 years. The risk of ICH among statin users (N = 43,434) was similar to that among nonusers (N = 18,818) with an adjusted HR and 95% confidence interval (CI) of 0.86 (0.73, 1.02). Compared with non-statin therapy, patients with low/moderate-intensity therapy had a lower risk of ICH (0.62: 0.52, 0.75), while patients with high-intensity therapy had a substantially higher risk (2.12: 1.72, 2.62). For patients with different types of statin therapy, adherence to rosuvastatin had the lowest risk of ICH compared to adherence to atorvastatin (0.46: 0.34, 0.63), followed by simvastatin (0.60: 0.45, 0.81). Conclusion: In patients with IS, any statin therapy was not associated with an increased risk of ICH. However there appeared to be differential risk according to the dose of statin with high-intensity statin therapy being associated with an increased risk of ICH, while low/moderate-intensity therapy was associated with a lower risk.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930231172623
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2211666-7
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  • 5
    Online Resource
    Online Resource
    Temperature-insensitive cable tension monitoring during the construction of a cable-stayed bridge with a custom-developed pulse elasto-magnetic instrument
    SAGE Publications ; 2019
    In:  Structural Health Monitoring Vol. 18, No. 5-6 ( 2019-11), p. 1982-1994
    Details
    In: Structural Health Monitoring, SAGE Publications, Vol. 18, No. 5-6 ( 2019-11), p. 1982-1994
    Abstract: Pulse elasto-magnetic method has numerous applications for monitoring cable tension force in cable-stayed bridges. In conventional pulse elasto-magnetic measurements, the feature parameters in frequency domain are seldom discussed. In this study, attempts are made to seek new parameters in frequency domain which are mainly influenced by cable tension force and less sensitive to temperature. A custom-developed pulse elasto-magnetic instrument is employed to conduct cable tension monitoring in the construction stage of a cable-stayed bridge. The field testing results show that only after temperature compensation, the monitoring results of the feature parameters extracted from the magnetic characteristic curve can reflect the stepped changes of cable tension force. Surprisingly, a new frequency-domain parameter, the summation of spectra amplitudes in a carefully selected frequency range, is found to be insensitive to temperature and can well reflect the stepped change behavior of cable tension force. The feasibility of this temperature-insensitive parameter for cable force measurements was verified by field test in two stay cables. The averaged value of the new parameter at each stage linearly depends on cable tension force. The findings about the new frequency-domain parameter may facilitate temperature-insensitive cable tension monitoring in cable-stayed bridge with a pulse elasto-magnetic instrument.
    Type of Medium: Online Resource
    ISSN: 1475-9217 , 1741-3168
    URL: Article
    DOI: 10.1177/1475921718814733
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2101420-6
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  • 6
    Online Resource
    Online Resource
    Claudin-7 Inhibits Proliferation and Metastasis in Salivary Adenoid Cystic Carcinoma Through Wnt/β-Catenin Signaling
    SAGE Publications ; 2020
    In:  Cell Transplantation Vol. 29 ( 2020-01-01), p. 096368972094358-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 29 ( 2020-01-01), p. 096368972094358-
    Abstract: The aim of this study was to investigate claudin-7 (CLDN7) expression in salivary adenoid cystic carcinoma (SACC) and its function in SACC cells. We determined CLDN7 expression in SACC tumors via immunohistochemistry and western blotting and evaluated the association between CLDN7 expression and clinicopathologic variables. Besides this, we constructed a stably transfected CLDN7 knockdown SACC-LM cell line via RNAi and assessed its biological behavior changes (cell viability, migration, and invasion). The correlation between CLDN7 and epithelial-mesenchymal transition (EMT) was analyzed. Additionally, a subcutaneous tumor formation model was used to assess SACC-LM cells tumorigenicity after the CLDN7 knockdown. In the present study, we found the CLDN7 expression of tumor group was lower than that in normal salivary glands and was significantly correlated with lymph node metastasis, recurrence, and gender. CLDN7 knockdown could add the proliferation and metastasis ability of SACC by regulating EMT through Wnt/β-catenin signaling pathway. In addition, CLDN7 knockdown in SACC promoted tumor growth in nude mice. CLDN7 inhibits cell proliferation and metastasis by inactivating the Wnt/β-catenin signaling in SACC. Thus, CLDN7 expression might be a useful marker to identify the potential for progression in SACC.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689720943583
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2020466-8
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  • 7
    Online Resource
    Online Resource
    Conformational Analysis and Binding Affinity Determination for Host—Guest Complexation of Alkali Metal Ions with Bis-Crown Ethers by Electrospray Mass Spectrometry and Molecular Modeling
    SAGE Publications ; 2002
    In:  European Journal of Mass Spectrometry Vol. 8, No. 5 ( 2002-10), p. 375-380
    Details
    In: European Journal of Mass Spectrometry, SAGE Publications, Vol. 8, No. 5 ( 2002-10), p. 375-380
    Abstract: This study presents the application of electrospray ionization mass spectrometry (ESI/MS) to investigate the host–guest complexation phenomenon for an array of alkali metal ions with bis[(benzo-15–crown-5)-15–ylmethyl] pimelate (BBCP). The results have shown that potassium ions possess the best binding affinity with the BBCP, owing to formation of the very stable sandwich-type (1:1) complexes and the strong K + cation-π electron interactions between the K + ion and the benzene rings of BBCP. The results of the competition experiments indicate the selectivity for BBCP toward the alkali metal ions is K + 〉 Rb + 〉 Cs + 〉 Na + 〉 Li + . In addition, combining the results of ESI/MS and molecular mechanics conformational searches reveal that the formation of sandwich-type (1:1) complexes can be observed for larger metal ions including K + , Rb + and Cs + . As for Na + ions, both 1:1 and 1:2 complexes can be observed.
    Type of Medium: Online Resource
    ISSN: 1469-0667 , 1751-6838
    URL: Article
    DOI: 10.1255/ejms.516
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2021540-X
    detail.hit.zdb_id: 2021340-2
    SSG: 11
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Research on the effect of cutting parameters on the machinability of polycrystalline Fe-Cr-W alloy by molecular dynamics simulation
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications
    Abstract: Molecular dynamics simulation has become a major theoretical analysis method for ultra precision machining of various materials. Large Scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) is used to construct a molecular dynamics model for cutting polycrystalline Fe-Cr-W alloy with CBN tool. The geometric parameters of the tool model are: the rake angle is −10°, the clearance angle is 7°, and the tool tip radius is 1.5 nm, including 8570 atoms. The size of the workpiece model is 24 nm × 10 nm × 10 nm, including 203,893 atoms. Ovito is used to visually analyze the influence of cutting parameters on the machinability of workpieces. The results show that the extrusion of the tool on the workpiece makes the atoms of the workpiece move and become chips and machined surfaces. Excessive cutting speed and depth will produce large hydrostatic stress, large cutting force, high cutting temperature and deteriorate the machined surface.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/09544054221138903
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2032745-6
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  • 9
    Online Resource
    Online Resource
    Analysis of machined surface topography of AISI M2 in hard turning based on Box-Behnken Design
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications
    Abstract: The surface topography of the workpiece directly affects its service performance. In this study, CLSM and SEM are used to analyze the effects of turning speed, turning feed, and turning depth on the three dimensional topography and surface defects of the machined surface. Amplitude parameters are used to characterize the machined surface topography of hard turning. Twelve groups of single factor experiments are used to analyze the influence of turning parameters on surface topography. Based on analysis of variance (ANOVA) and 15 groups of Box-Behnken Design (BBD), whether cutting parameters have significant influence on arithmetic mean deviation ( S a ) is analyzed. A mathematical statistical model of S a is established by Response Surface Methodology, and the effectiveness of the model is verified by 10 groups of experiments. By analyzing the research results, it can be concluded that: (1) The consistency of the surface topography of hard turning is good; (2) In the turning feed direction, the surface defects of the machined surface by hard turning include turning grooves, material side flow, adhering chips, and material surface tearing; (3) In hard turning, the most significant factor affecting the three dimensional roughness ( S a ) is the turning feed.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/09544054231157261
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032745-6
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  • 10
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    Online Resource
    Tumor necrosis factor- α induces epithelial–mesenchymal transition of renal cell carcinoma cells via a nuclear factor kappa B-independent mechanism
    SAGE Publications ; 2011
    In:  Experimental Biology and Medicine Vol. 236, No. 9 ( 2011-09), p. 1022-1029
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 236, No. 9 ( 2011-09), p. 1022-1029
    Abstract: Chronic low dose of tumor necrosis factor- α (TNF- α) stimulation promotes tumorigenesis by facilitating tumor proliferation and metastasis. The plasma levels of TNF- α are increased in patients with renal cell carcinoma (RCC). Furthermore, high-grade clear cell RCC cell lines secrete more TNF- α than low-grade ones, and allow low-grade cell lines' gain of invasive ability. However, the molecular mechanism of TNF- α in mediating progression of RCC cells remains unclear. In the present study, TNF- α induced epithelial–mesenchymal transition (EMT) of RCC cells by repressing E-cadherin, promoting invasiveness and activating matrix metalloproteinase (MMP) 9 activity. RCC cells underwent promoted growth in vivo following stimulation with TNF- α. In addition, TNF- α induced phosphorylation of extracellular signal-regulated kinase, nuclear factor kappa B (NF- κB) and Akt in a time-dependent manner, and increased nuclear translocation and promoter activity of NF- κB. To investigate the role of NF- κB activation in TNF- α-induced EMT of RCC, we employed chemical inhibitors (NF- κB activation inhibitor and Bay 11-7082) and transfected dominant-negative (pCMV-I κB αM) and overexpressive (pFLAG-p65) vectors of NF- κB. While overexpression of NF- κB p65 alone could induce E-cadherin loss in RCC, EMT phenotypes and MMP9 expressions induced by TNF- α were not reversed by the inhibitors of NF- κB activation. These results suggest that the TNF- α signaling pathway is involved in the tumorigenesis of RCC. However, NF- κB activation is not crucial for invasion and EMT enhanced by TNF- α in RCC cells.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2011.011058
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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