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  • 1
    Online Resource
    Online Resource
    Recombinant Newcastle Disease virus Expressing IL15 Demonstrates Promising Antitumor Efficiency in Melanoma Model
    SAGE Publications ; 2015
    In:  Technology in Cancer Research & Treatment Vol. 14, No. 5 ( 2015-10), p. 607-615
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 14, No. 5 ( 2015-10), p. 607-615
    Abstract: Recombinant Newcastle Disease Virus (rNDV) has shown oncolytic therapeutic effect in preclinical studies. Previous data indicate that rNDV carrying IL2 has shown promise in cancer therapy. Due to the significant side effects of IL2, IL15 has been introduced into cancer therapy. A number of studies have suggested that IL15 efficiently enhances the activities of CTL and NK cells and inhibits the tumor recurrence and metastasis. Furthermore, IL15 is less toxic than IL2. Therefore, we hypothesize that a recombinant NDV expressing IL15 would be a promising agent for the treatment of malignant tumors. The human IL15 gene or IL2 gene was incorporated into the genome of lentogenic LaSota strain at the position between the HN and L genes (namely rNDV-IL15 or rNDV-IL2). The two viruses efficiently infected tumor cells and expressed IL15 or IL2 protein. Melanoma tumor-bearing mice were treated by intra-tumoral (i.t.) injection of rNDV-IL15 or rNDV-IL2. Both rNDV-IL15 and rNDV-IL2 effectively suppressed tumor growth compared with rNDV. The 120-day survival rate of rNDV-IL15- treated group was 12.5% higher than that of rNDV-IL2 group, although the difference was not statistically significant, both recombinant viruses had strong abilities to induce CD41 T cell and CTL cell responses. However, rNDV-IL15 significantly induced more IFN-γ release and stimulated more CD81 T cells infiltration in the tumor sites compared with rNDV-IL2. In the tumor re-challenged experiment, the survival rates of rNDV-IL15 group and rNDV-IL2 group were statistically higher than that of PBS group. The survival rate of rNDV-IL15 group was 26.67% higher than that of rNDV-IL2 group although the difference was not statistically significant. In conclusion, rNDV-IL15 is a promising antitumor agent against melanoma.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.7785/tcrt.2012.500414
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 2
    Online Resource
    Online Resource
    Triacetyl-3-hydroxyphenyladenosine, a derivative of cordycepin, attenuates atherosclerosis in apolipoprotein E-knockout mice
    SAGE Publications ; 2012
    In:  Experimental Biology and Medicine Vol. 237, No. 11 ( 2012-11), p. 1262-1272
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 237, No. 11 ( 2012-11), p. 1262-1272
    Abstract: The cholesterol-modulating, immune-regulating and anti-inflammatory properties of cordycepin are well documented. Here we examined the effects of triacetyl-3-hydroxyphenyladenosine (THPA), a derivative of cordycepin, on the development of atherosclerosis (AS) in apolipoprotein E-knockout (apoE -/- ) mice. The atherosclerotic lesion formation displayed by the oil red O staining-positive area was reduced significantly in either the aortic root section or the whole aorta en face in THPA-administrated apoE -/- mice. Plasma analysis by enzymatic method or enzyme-linked immunosorbent assay (ELISA) showed that high-density lipoprotein-cholesterol (HDL-C) was decreased, whereas apolipoprotein A-I (apoA-I) levels were markedly increased by THPA. In addition, ELISA and spectrophotometric measurement showed that plasma levels of tumor necrosis factor-α, interleukin-1 and malondialdehyde were decreased in mice treated with THPA. Realtime polymerase chain reaction detection disclosed that the expression of several transporters involved in reverse cholesterol transport was induced by THPA, and the expression of hepatic ABCA1 and apoA-I, which play roles in the maturation of HDL-C, was also elevated in the THPA-treated groups. Moreover, THPA enhanced the expression of endothelial nitric oxide synthase (NOS), and reduced the expression of inducible NOS and lectin-like oxidized LDL receptor-1 in the aorta, suggesting that THPA can exert endothelial protection effects. In addition, the expression or activation of several proinflammatory factors in the aorta was suppressed by THPA. In conclusion, our results reveal the inhibitory effects of THPA on AS in apoE -/- mice.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2012.011401
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2020856-X
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  • 3
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    Online Resource
    Nicotinamide mononucleotide ameliorates acute lung injury by inducing mitonuclear protein imbalance and activating the UPR mt
    SAGE Publications ; 2022
    In:  Experimental Biology and Medicine Vol. 247, No. 14 ( 2022-07), p. 1264-1276
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 247, No. 14 ( 2022-07), p. 1264-1276
    Abstract: Mitochondria need to interact with the nucleus under homeostasis and stress to maintain cellular demands and nuclear transcriptional programs. Disrupted mitonuclear interaction is involved in many disease processes. However, the role of mitonuclear signaling regulators in endotoxin-induced acute lung injury (ALI) remains unknown. Nicotinamide adenine dinucleotide (NAD + ) is closely related to mitonuclear interaction with its central role in mitochondrial metabolism. In the current study, C57BL/6J mice were administrated with lipopolysaccharide 15 mg/kg to induce endotoxin-induced ALI and investigated whether the NAD + precursor nicotinamide mononucleotide (NMN) could preserve mitonuclear interaction and alleviate ALI. After pretreatment with NMN for 7 days, NAD + levels in the mitochondrial, nucleus, and total intracellular were significantly increased in endotoxemia mice. Moreover, supplementation of NMN alleviated lung pathologic injury, reduced ROS levels, increased MnSOD activities, mitigated mitochondrial dysfunction, ameliorated the defects in the nucleus morphology, and these cytoprotective effects were accompanied by preserving mitonuclear interaction (including mitonuclear protein imbalance and the mitochondrial unfolded protein response, UPR mt ). Furthermore, NAD + -mediated mitonuclear protein imbalance and UPR mt are probably regulated by deacetylase Sirtuin1 (SIRT1). Taken together, our results indicated that NMN pretreatment ameliorated ALI by inducing mitonuclear protein imbalance and activating the UPR mt in an SIRT1-dependent manner.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/15353702221094235
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2020856-X
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  • 4
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    Online Resource
    Efficient Synthesis of the Odourant, 2-Nonen-4-Olide
    SAGE Publications ; 2012
    In:  Journal of Chemical Research Vol. 36, No. 8 ( 2012-08), p. 495-496
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 36, No. 8 ( 2012-08), p. 495-496
    Abstract: A three-step synthesis of 2-nonen-4-olide starting from heptanal is reported. (E)-3-Nonenoic acid, prepared by Knoevenagel condensation of malonic acid and heptanal, was oxidised by performic acid, a process accompanied by lactonisation, to give 3-hydroxynonan-4-olide in 85% yield. This lactone when reacted with MsCl in the presence of Et 3 N gave, by elimination, 2-nonen-4-olide in 88% yield. The overall yield was 75%. The odour of the product was evaluated by GC-olfactory analysis and sniffing blotter confirming an oily, coconut-like, and rancid odour.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751912X13402955389383
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 3010810-X
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  • 5
    Online Resource
    Online Resource
    Mechanical properties and environmental performance of seawater sea-sand self-compacting Concrete
    SAGE Publications ; 2022
    In:  Advances in Structural Engineering Vol. 25, No. 15 ( 2022-11), p. 3114-3136
    Details
    In: Advances in Structural Engineering, SAGE Publications, Vol. 25, No. 15 ( 2022-11), p. 3114-3136
    Abstract: Due to the constituted ingredients are both rich in reserves, seawater sea-sand self-compacting concrete (SWSS-SCC) today has been treated as an ideal material in constructing island and coastal structures. The technique feasibility of applying SWSS-SCC in real engineering has been recognized by investigating the material properties, but its environmental impacts (EIs) has rarely been concerned at current stage. Under such a background, a refined life cycle assessment model of SWSS-SCC was developed in this study based on the China’s latest production data. Life cycle phases considered include extracting and preparing raw materials, component material production, mixing concrete and transportation occurred in the whole processes. After verifying the model, the impacts of several factors like concrete curing method, fly ash incorporation content, sea-sand transportation distance and electricity generation approach, which have never been investigated before, on the energy cost and carbon dioxide equivalent emissions generated in manufacturing SWSS-SCC were discussed. The simulated results showed that: (a) Using seawater and sea-sand slightly increases the concrete’s compressive and tensile strengths. Replacing some cement with fly ash notably decreases the early-age strengths, but curing at 60°C can offset that effect. (b) Replacing fresh water and natural sand by sea-water and sand in Humen Town decreases the production EIs of SWSS-SCC. For this concrete, cement production and raw material transportation are the main contributors to the overall EIs. (c) During producing SWSS-SCC, using electricity generated from clean fuels can effectively reduce the system’s EI, but changing fuel used to fire the cement kiln has little effect. (d) High temperature curing to increase the fly ash content is not environmentally sound. Reducing the mixture’s water to binder ratio is more benefit for incorporating fly ash. (e) From an environmental evaluation view, applying SWSS-SCC is more ecological in island constructions than coastal buildings.
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    URL: Article
    DOI: 10.1177/13694332221119863
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2026561-X
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  • 6
    Online Resource
    Online Resource
    Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382094805-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382094805-
    Abstract: Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820948053
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
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  • 7
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    Online Resource
    The Structure and Nonisothermal Crystallization Kinetics of HDPE Nanocomposites Filled with Mg 2 Al–LDH
    SAGE Publications ; 2012
    In:  Polymers and Polymer Composites Vol. 20, No. 8 ( 2012-10), p. 701-710
    Details
    In: Polymers and Polymer Composites, SAGE Publications, Vol. 20, No. 8 ( 2012-10), p. 701-710
    Abstract: High-density polyethylene (HDPE)/Mg 2 Al–layered double hydroxide (Mg 2 Al–LDH) nanocomposites with an ethylene-acrylic acid random copolymer (EAA)/Mg 2 Al–LDH master batch were prepared by melt-mixing. The structure of the nanocomposites was characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The results demonstrate the formation of the nanocomposites with exfoliated/intercalated layered double hydroxides well distributed in the HDPE matrix. The nonisothermal crystallization behaviour of master batch-based HDPE nanocomposites was studied by using differential scanning calorimetry (DSC). The crystallization behaviour of HDPE/Mg 2 Al–LDH nanocomposites was well defined by the Avrami analysis and Jeziorny method, as well as the combined Avrami and Ozawa analysis (MO's model). The results reveal that a very small amount of Mg 2 Al–LDH (1%) accelerates the crystallization process in comparison with the neat HDPE, and the high crystallization rate is attributed to the nucleating effect of the exfoliated nanoparticles. Overall, the exfoliated Mg 2 Al–LDH particles act as the nucleating agent, and therefore distinctly change the type of nucleation, growth and geometry of HDPE crystals.
    Type of Medium: Online Resource
    ISSN: 0967-3911 , 1478-2391
    URL: Article
    DOI: 10.1177/096739111202000805
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2099644-5
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  • 8
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    Online Resource
    Preparation and properties of chitosan particle-reinforced polybenzoxazine blends
    SAGE Publications ; 2015
    In:  Journal of Composite Materials Vol. 49, No. 20 ( 2015-08), p. 2449-2458
    Details
    In: Journal of Composite Materials, SAGE Publications, Vol. 49, No. 20 ( 2015-08), p. 2449-2458
    Abstract: This study investigates the effects of chitosan particles (CTS) on the curing behavior, thermal and thermomechanical properties of polybenzoxazine matrix. The morphological, thermomechanical, and thermal properties of the blends are analyzed using scanning electron microscopy (SEM), dynamic scanning calorimetry (DSC), dynamical mechanical analyzer (DMA), and thermogravimetric analysis (TGA). The results show that the −NH 2 groups on the chitosan can act as an active crosslinking position and hydrogen bonding. The SEM micrographs reveal good compatibility between the blend components. Furthermore, the values of glass transition temperatures, char yields, and storage moduli of the cured blends are found to be increased with the increase of CTS contents to reach 191℃, 34%, 4.3 GPa, respectively, at 10% of CTS content.
    Type of Medium: Online Resource
    ISSN: 0021-9983 , 1530-793X
    URL: Article
    DOI: 10.1177/0021998314548606
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 160490-9
    detail.hit.zdb_id: 2081924-9
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  • 9
    Online Resource
    Online Resource
    Melting and crystallization behaviors of electrostatic spinning polycaprolactone/polyethylene glycol blends
    SAGE Publications ; 2012
    In:  High Performance Polymers Vol. 24, No. 5 ( 2012-08), p. 441-446
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 24, No. 5 ( 2012-08), p. 441-446
    Abstract: Polycaprolactone/polyethylene glycol (PCL/PEG) blends were prepared by electrostatic spinning. The melting behavior and isothermal, non-isothermal crystallization kinetics were investigated using differential scanning calorimetry (DSC). The results showed the DSC thermograms of blend samples. With increasing PEG content, the position of the crystallization peak shifted to a higher temperature, while the position of the melting peak shifted slightlys. With increasing the heating rates, the position of the melting peak shifted to a higher temperature and the total heat of fusion also gradually increased. Both PCL and PEG could crystallize. By DSC, the PEG and PCL mutually promote to develop a thicker crystal and more perfect crystallite. This effect of promotion may result from the interaction of the molecular chain period of the two polymers. The Avrami equation described the non-isothermal crystallization kinetics of this blend very well.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008312446764
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 1483713-4
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  • 10
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    Online Resource
    Clinical Value of Long Noncoding RNA HOTAIR as a Novel Biomarker in Digestive Cancers: A Meta-Analysis
    SAGE Publications ; 2018
    In:  Technology in Cancer Research & Treatment Vol. 17 ( 2018-01), p. 153303461875678-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 17 ( 2018-01), p. 153303461875678-
    Type of Medium: Online Resource
    ISSN: 1533-0338 , 1533-0338
    URL: Article
    DOI: 10.1177/1533034618756783
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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