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  • SAGE Publications  (98)
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  • 1
    Online Resource
    Online Resource
    Dynamics design for multiple launch rocket system using transfer matrix method for multibody system
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 230, No. 14 ( 2016-12), p. 2557-2568
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 230, No. 14 ( 2016-12), p. 2557-2568
    Abstract: Dynamics design for complex mechanical systems has become an important research field and development direction at present, capturing attentions of an increasing number of engineers and scientists worldwide. Based on many advantages of the transfer matrix method for multibody system in studying multibody system dynamics, a design problem of a multiple launch rocket system is solved in this paper. Particular attention is addressed to model actions of the exhaust flow on the multiple rocket launcher, which are associated with firing order and firing intervals of rockets. Combined with a genetic algorithm, firing order and firing intervals are optimized to achieve optimum impact point dispersion reduction. The results of numerical simulation and verification tests show good agreement, while the dispersion characteristics of rockets have been improved in a low-cost way.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410016629498
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2032759-6
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  • 2
    Online Resource
    Online Resource
    Plasma d -Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease
    SAGE Publications ; 2016
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 22, No. 7 ( 2016-10), p. 633-640
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 22, No. 7 ( 2016-10), p. 633-640
    Abstract: Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiographic-proven patients with CAD were consecutively enrolled. Then, all patients were subjected to follow up for an average of 18 months (ranged from 14 to 1037 days). The relationships of the plasma d-dimer with the severity of CAD and future clinical outcomes were evaluated. We found that plasma d-dimer was higher in patients with prior myocardial infarction (MI) than that in patients with nonprior MI ( P = .006). Multivariate linear regression analysis suggested that the plasma d-dimer was linked to the severity of CAD assessed by Gensini score (β = 0.052, 95% confidence interval [CI]: 1.20-6.84, P = .005) even after adjusting for confounding factors. During the follow-up, 42 patients underwent prespecified outcomes. After adjustment for multiple variables in the Cox regression model, the d-dimer levels remained to be a potential predictor of total outcome (hazard ratio = 1.22, 95% CI: 1.09-1.37, P = .001). Therefore, plasma d-dimer levels appeared to be a useful predictor for the severity of CAD and the subsequent major clinical events.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029616634885
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2230591-9
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  • 3
    Online Resource
    Online Resource
    Analytical characterization and clinical performance evaluation of a new point-of-care testing system for high-sensitivity cardiac troponin I assay
    SAGE Publications ; 2021
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 58, No. 6 ( 2021-11), p. 579-585
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 58, No. 6 ( 2021-11), p. 579-585
    Abstract: We aimed to evaluate the analytical performance and clinical diagnostic accuracy of the SuperFlex point-of-care testing (POCT) high-sensitivity cardiac troponin I (hs-cTnI) assay system. Method The imprecision, the limit of blank, the limit of detection, the limit of quantitation, linearity and comparability were assessed as per the Clinical and Laboratory Standards Institute guidelines. Also, the 99th-percentile reference value and diagnostic accuracy were evaluated. Results The reproducibility and total imprecision were 1.52–1.92% and 2.69–2.92%, respectively. Limit of blank and limit of detection were 1 ng/L and 1.8 ng/L, respectively, and limit of quantitation was 12 ng/L at 10% coefficient of variation (CV). The results met the requirements of linearity, and the correlation coefficient was 0.996. The SuperFlex POCT results had good agreement with those obtained by the Siemens Advia 2400. The CV% was 7.24% at the 99th percentile concentration (p99th) of 25.6 ng/L (95% confidence interval: 22.0–33.3 ng/L) from 620 healthy subjects. The sex-partitioned CV% and p99th were 7.15% at 27 ng/L (males; n = 308) and 7.35% at 24 ng/L (females; n = 312), respectively ( P  〈  0.0001). The hs-cTnI detection rate of all observed healthy individuals from limit of detection to 99th was 82.57% by the SuperFlex POCT assay, 89.90% for the males and 75.48% for the females. The sensitivity, specificity, positive predictive value and negative predictive value of diagnostic performance for acute myocardial infarction were 100%, 81.25%, 57% and 100%, respectively. Conclusions The SuperFlex POCT system showed the analytical performance characteristics required for enabling the clinical use of a hs-cTnI assay.
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1177/00045632211027604
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2041298-8
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  • 4
    Online Resource
    Online Resource
    Volume computed tomography perfusion as a predictive marker for treatment response to concurrent chemoradiotherapy in cervical cancer: a prospective study
    SAGE Publications ; 2021
    In:  Acta Radiologica Vol. 62, No. 2 ( 2021-02), p. 281-288
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 62, No. 2 ( 2021-02), p. 281-288
    Abstract: Computed tomography perfusion (CTP) can provide information on blood perfusion as a reliable marker of tumor response to therapy. Purpose To assess the role of volume CTP (vCTP) parameters in predicting treatment response to concurrent chemoradiotherapy (CCRT) for cervical cancer. Material and Methods Thirty-three patients with cervical cancer underwent vCTP. Three CTP parameters of cervical cancer—including arterial flow (AF), blood volume (BV), and permeability surface (PS)—were measured in two different ways: the region of interest incorporating the “local hot” with the highest enhancement and “cold spot” with the lowest enhancement; and “whole-tumor” measurements. The patients were divided into non-residual and residual tumor groups according to the short-term response to treatment. The clinical and perfusion parameters were compared between the two groups. Results There was no significant difference in age, body mass index, FIGO stage, pathological grade, or pretreatment tumor size between the two groups ( P  〉  0.05). The non-residual tumor group had higher pretreatment AF in high-perfusion and low-perfusion subregions than the residual tumor group ( P  〈 0.05), but the AF in whole-tumor regions was not different between the two groups ( P  〉  0.05). There were no differences in BV and PS between the two groups ( P  〉  0.05). The diagnostic potency of AF in the low-perfusion subregion was higher than that in the high-perfusion subregion. Conclusion vCTP parameters are valuable for the prediction of short-term effects. The AF in the low-perfusion subregion was a more effective index for predicting treatment response to CCRT of cervical cancer.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185120919261
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2024579-8
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  • 5
    Online Resource
    Online Resource
    Synthesis of a benzoxazine monomer contained hyperbranched polysiloxane and the characteristics of its polymer alloys blend with bismaleimides
    SAGE Publications ; 2020
    In:  High Performance Polymers Vol. 32, No. 5 ( 2020-06), p. 540-549
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 32, No. 5 ( 2020-06), p. 540-549
    Abstract: A novel benzoxazine monomer contained hyperbranched polysiloxane structure (HBPSi-BOZ) was synthesized via a solvent process based on the polyformaldehyde, aniline, and a new hyperbranched polysiloxane with terminal amino groups (HBPSi-NH 2 ). The HBPSi-BOZ was then used as modified phase to blend with bismaleimides (BMIs) resin, and a polymer alloy HBPSi-BOZ/BMI was successfully prepared. The thermal resistant properties, mechanical properties, and tribological properties of HBPSi-BOZ/BMI resins with different contents of HBPSi-BOZ prepared were researched to get an optimal ratio. The thermogravimetric analysis was also carried out to study the polymerization process and stability of HBPSi-BOZ/BMI resins. The results showed that as the thermal resistance increased, the wear resistance and mechanical properties of HBPSi-BOZ/BMI resins were also enhanced.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008319886642
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 1483713-4
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  • 6
    Online Resource
    Online Resource
    Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Gastroenterology Vol. 15 ( 2022-01), p. 175628482211162-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 15 ( 2022-01), p. 175628482211162-
    Abstract: The Coronavirus Disease 2019 (COVID-19) pandemic poses a massive crisis to global public health. Gastrointestinal (GI) symptoms are increasingly reported in COVID-19. The characteristics of laboratory findings of COVID-19 are critical for clinical diagnosis and treatment. Objectives: The study aimed to summarize laboratory features in COVID-19 with GI symptoms and non-GI symptoms. Design: This study was a systematic review and meta-analysis. Electronic literature searches were conducted for studies that included patients infected COVID-19 with GI symptoms and non-GI symptoms. GI symptoms included diarrhea, abdominal pain, nausea and vomiting, and anorexia. This study used a random-effects model to assess pooled data. Data sources and methods: We systematically searched PubMed, Embase, Cochrane, Web of Science for studies through 31 October 2021, with no language restrictions. We used the following search terms: ‘COVID-19’ OR ‘2019-nCoV’ OR ‘SARS-CoV-2’ OR ‘coronavirus 2019’ OR ‘severe acute respiratory syndrome coronavirus 2’ OR ‘coronavirus’ OR ‘novel coronavirus’ OR ‘nCoV’ AND ‘gastrointestinal symptoms’ OR ‘digestive symptoms’ AND ‘clinical feature’ OR ‘clinical characteristics.’ Data mostly originated from Chinese and American studies. Results: Of 796 identified studies, 14 were eligible and were included in our analysis ( N = 8396 participants). Meta-analysis showed that GI symptoms group had an elevated alanine aminotransferase (ALT) [pooled mean difference (MD), 4.5 U/L; 95% confidence interval, [0.45, 8.55]; p = 0.03; I 2  = 87%]. No publication bias was detected by Begg’s and Egger’s regression test ( p = 0.130). COVID-19 with the GI symptoms also showed a trend toward decreased white blood cell count, lymphopenia, neutrophilia, thrombocytopenia and elevated total bilirubin. Conclusion: GI symptoms are common in COVID-19. No significant differences were found in most laboratory indicators except elevated ALT. Registration: CRD42020209039 (PROSPERO).
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/17562848221116264
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2440710-0
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  • 7
    Online Resource
    Online Resource
    Significance of Detecting Circulating Hepatocellular Carcinoma Cells in Peripheral Blood of Hepatocellular Carcinoma Patients by Nested Reverse Transcription-polymerase Chain Reaction and its Clinical Value: A Retrospective Study
    SAGE Publications ; 2014
    In:  Tumori Journal Vol. 100, No. 5 ( 2014-01), p. 536-540
    Details
    In: Tumori Journal, SAGE Publications, Vol. 100, No. 5 ( 2014-01), p. 536-540
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/1660.18174
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 8
    Online Resource
    Online Resource
    Expression and prognostic value of ING3 in human primary hepatocellular carcinoma
    SAGE Publications ; 2012
    In:  Experimental Biology and Medicine Vol. 237, No. 4 ( 2012-04), p. 352-361
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 237, No. 4 ( 2012-04), p. 352-361
    Abstract: The tumor-suppressor ING3 has been shown to be involved in tumor transcriptional regulation, apoptosis and the cell cycle. Some studies have demonstrated that ING3 is dysregulated in several types of cancers. However, the expression and function of ING3 in human hepatocellular carcinoma (HCC) remains unclear. The aim of this study is to investigate ING3 expression in hepatic tumors and its clinical relevance in hepatic cancer. The expression of ING3 protein was examined in 120 dissected HCC tissues and 47 liver tissues adjacent to the tumor by immunohistochemical assays and confirmed by Western blot analysis in 20 paired frozen tumor and non-tumor liver tissues. The relationship between ING3 staining and clinico-pathological characteristics of HCC was further analyzed. The mRNA expression of ING3 in the dissected tissues was also analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and realtime PCR. Both mRNA and protein concentrations of ING3 were found to be downregulated in the majority of HCC tumors in comparison with matched non-tumor hepatic tissues. Analysis of the relationship between ING3 staining and clinico-pathological characteristics of HCC showed that the low expression of ING3 protein is correlated with more aggressive behavior of the tumor. Kaplan–Meier curves demonstrated that patients with a low expression of ING3 have a significantly increased risk of shortened survival time. In addition, multivariate analysis suggested that the level of ING3 expression may be an independent prognostic factor. Our findings indicate that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2011.011346
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Pt/Al 2 O 3 Catalyst Prepared from Water-in-Oil Microemulsion and Used in Catalytic Hydrogenation
    SAGE Publications ; 2015
    In:  Progress in Reaction Kinetics and Mechanism Vol. 40, No. 2 ( 2015-04), p. 190-200
    Details
    In: Progress in Reaction Kinetics and Mechanism, SAGE Publications, Vol. 40, No. 2 ( 2015-04), p. 190-200
    Abstract: Pt/Al 2 O 3 catalyst was prepared from a cetyltrimethylammonium bromide (CTAB)/ n-butanol/cyclohexane water-in-oil (w/o) microemulsion. The preparation conditions of Pt/Al 2 O 3 catalyst were investigated and are discussed in detail. Transmission electron microscopy (TEM) showed uniform Pt nanoparticles (about 3 nm) with high dispersion in the catalyst. The Pt/Al 2 O 3 catalyst exhibited excellent catalytic properties in the liquid-phase hydrogenation of o-chloronitrobenzene ( o-CNB) to o-chloroaniline ( o-CAN). After 60-min reaction at normal pressure and 303 K, the conversion of o-CNB was 81.1% and the selectivity to o-CAN was 96.2%. Kinetic study showed o-CNB hydrogenation to be a first-order reaction with an apparent activation energy of 56.37 kJ mol −1 . The microemulsion-derived catalyst shows a higher catalytic activity than an impregnation-drived catalyst.
    Type of Medium: Online Resource
    ISSN: 1471-406X , 1471-406X
    URL: Article
    DOI: 10.3184/146867815X14262622455960
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2018085-8
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  • 10
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    Online Resource
    Quasi-static compressive strength of polymethacrylimide foam-filled square carbon fiber reinforced composite honeycombs
    SAGE Publications ; 2021
    In:  Journal of Sandwich Structures & Materials Vol. 23, No. 6 ( 2021-09), p. 2358-2374
    Details
    In: Journal of Sandwich Structures & Materials, SAGE Publications, Vol. 23, No. 6 ( 2021-09), p. 2358-2374
    Abstract: A novel polymethacrylimide foam-filled square carbon fiber reinforced composite honeycomb core was proposed and prepared. Numerical simulations and theoretical predictions were conducted to study the quasi-static compressive strength of the hybrid core. The effects of material and structural parameters on the compressive strength of the core were analyzed. The results show that the failure modes of the core under quasi-static compression include elastic buckling and plastic fracture failure. The change law of the compressive strength of the core with the increase in the relative density can be divided into three phases, including post-buckling load bearing stage, buckling failure stage, and fracture stage. The failure modes of the core and the change law of the compressive strength with the increase of the relative density vary with the material and structural parameters. The research provides an accurate method to predict the compressive strength of the foam-filled composite honeycomb, which can help to guide the design and optimization of light weight and energy-efficient sandwich cores.
    Type of Medium: Online Resource
    ISSN: 1099-6362 , 1530-7972
    URL: Article
    DOI: 10.1177/1099636220909819
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2098561-7
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