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  • SAGE Publications  (39)
  • 1
    Online Resource
    Online Resource
    The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis
    SAGE Publications ; 2022
    In:  Clinical Medicine Insights: Oncology Vol. 16 ( 2022-01), p. 117955492211395-
    Details
    In: Clinical Medicine Insights: Oncology, SAGE Publications, Vol. 16 ( 2022-01), p. 117955492211395-
    Abstract: Endocrine hormones influence tumor progression and the response to treatment. Despite the importance of immune checkpoint inhibitors (ICIs) as treatments for advanced non-small cell lung cancer (NSCLC), few studies have explored the effects of hormone levels in NSCLC patients on the effectiveness of ICI therapies. We thus investigated the effects of baseline blood markers in patients with advanced NSCLC on ICI treatments. Methods: Patients with advanced NSCLC who received programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors at Chungnam National University Hospital between December 2016 and November 2020 and who lacked any history of thyroid gland-related diseases were analyzed retrospectively. We collected clinical information and baseline laboratory data, including the levels of endocrine hormones, cytokines, complete blood counts (CBCs), and peripheral blood chemistry panels. We explored the relationships of hormone levels with clinical outcomes (overall survival [OS], progression-free survival [PFS] , and best response), liver metastasis, and blood markers using the Kaplan–Meier method, Cox’s proportional hazards regression, and logistic regression. Results: A total of 113 patients were enrolled. A shorter PFS was independently associated with liver metastasis, higher cortisol levels, and lower hemoglobin (Hb) levels; a shorter OS was associated with liver metastasis, lower tri-iodothyronine (T3) levels, higher lactate dehydrogenase (LDH) levels, and lower albumin levels. Patients with low T3 levels exhibited a shorter PFS and OS, and a poorer best response. Patients with low T3 levels tended to have higher disease progression rates, lower levels of adrenocorticotropic hormone (ACTH), C-peptide, albumin, Hb, and neutrophil-to-lymphocyte ratio, and higher levels of interleukin (IL)-6, white blood cells, platelets, compared with those with normal T3 levels. We found a significant association between a low T3 level and liver metastasis. Conclusions: We found the baseline T3 level was associated with both prognosis and the response to ICIs in patients with advanced NSCLC, probably reflecting impaired liver function and systemic inflammation induced by the interaction of T3 with other biomarkers, such as IL-6, ACTH, cortisol, C-peptide, Hb, LDH, and albumin.
    Type of Medium: Online Resource
    ISSN: 1179-5549 , 1179-5549
    URL: Article
    DOI: 10.1177/11795549221139522
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2577877-8
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  • 2
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    Comparison of General Anesthesia and Conscious Sedation during Computed Tomography–Guided Radiofrequency Ablation of T1a Renal Cell Carcinoma
    SAGE Publications ; 2018
    In:  Canadian Association of Radiologists Journal Vol. 69, No. 1 ( 2018-02), p. 24-29
    Details
    In: Canadian Association of Radiologists Journal, SAGE Publications, Vol. 69, No. 1 ( 2018-02), p. 24-29
    Abstract: Percutaneous radiofrequency ablation is so painful that this treatment requires pain control such as conscious sedation or general anesthesia. It is still unclear which type of anesthesia is better for treatment outcomes of renal cell carcinoma. This study aimed to compare general anesthesia and conscious sedation in treating patients with renal cell carcinoma with radiofrequency ablation. Methods Between 2010 and 2015, 51 patients with biopsy-proven renal cell carcinomas ( 〈 4 cm) were treated with computed tomography–guided radiofrequency ablation. General anesthesia was performed in 41 and conscious sedation was performed in 10 patients. Tumour size, local tumour progression, metastasis, major complication, effective dose, glomerular filtration rate difference, and recurrence-free survival rate were compared between these groups. Results The mean tumour size was 2.1 cm in both groups ( P = .673). Local tumour progression occurred in 0% (0 of 41) of the general anesthesia group, but in 40% (4 of 10) of the conscious sedation group ( P = .001). Metastases in these groups occurred in 2.4% (1 of 41) of the general anesthesia group and 20% (2 of 10) of the conscious sedation group ( P = .094). No major complications developed in either group after the first radiofrequency ablation session. The mean effective doses in these groups were 21.7 mSv and 21.2 mSv, respectively ( P = .868). The mean glomerular filtration rate differences in the general anesthesia and conscious sedation groups were −13.5 mL/min/1.73 m 2 and −19.1 mL/min/1.73 m 2 , respectively ( P = .575). Three-year recurrence-free survival rates in these groups were 97.6% and 60.0%, respectively ( P = .001). Conclusions General anesthesia may provide better intermediate outcomes than conscious sedation in treating small renal cell carcinomas with radiofrequency ablation.
    Type of Medium: Online Resource
    ISSN: 0846-5371 , 1488-2361
    URL: Article
    DOI: 10.1016/j.carj.2017.07.003
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2068691-2
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  • 3
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    Comparison of Clinical Presentation and Surgical Outcomes Between Recurrent Acute Rhinosinusitis and Chronic Rhinosinusitis
    SAGE Publications ; 2018
    In:  Annals of Otology, Rhinology & Laryngology Vol. 127, No. 11 ( 2018-11), p. 763-769
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 127, No. 11 ( 2018-11), p. 763-769
    Abstract: The authors assessed clinical presentations and anatomic variants among patients with recurrent acute rhinosinusitis (RARS), chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP), and CRS with nasal polyps (CRSwNP). Additionally, differences in the postoperative improvement of each category were evaluated. Methods: The authors performed an analysis of 304 patients who underwent endoscopic sinus surgery. They were divided into groups with RARS, CRSsNP, and CRSwNP. Patients had to complete the Sino-Nasal Outcome Test (SNOT-20) on surgery 1 day before and 6 months after surgery. Patient demographics and comorbidities were reviewed. We reviewed all patients’ computed tomographic findings to analyze anatomic variants. Results: No significant differences were found among the average preoperative SNOT-20 scores of the 3 groups. Patients with RARS were significantly more likely to show agger nasi cells, Haller cells, and septal deviation on computed tomography. Those with CRSwNP had significantly smaller mean infundibular widths. All groups showed significantly improved SNOT-20 scores postoperatively. Conclusion: The different anatomic variants found among patients with RARS, CRSsNP, and CRSwNP can facilitate surgical prognostic evaluation.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/0003489418792942
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2033055-8
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  • 4
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    Clusterin Expression in the Early Process of Pancreas Regeneration in the Pancreatectomized Rat
    SAGE Publications ; 2003
    In:  Journal of Histochemistry & Cytochemistry Vol. 51, No. 10 ( 2003-10), p. 1355-1365
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 51, No. 10 ( 2003-10), p. 1355-1365
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/002215540305101012
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 5
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    Is Facial or Head Pain Related to the Location of Lesions on Computed Tomography in Chronic Rhinosinusitis?
    SAGE Publications ; 2017
    In:  Annals of Otology, Rhinology & Laryngology Vol. 126, No. 8 ( 2017-08), p. 589-596
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 126, No. 8 ( 2017-08), p. 589-596
    Abstract: Facial or head pain is not an infrequent symptom among patients diagnosed with chronic rhinosinusitis (CRS), but few reports have investigated the pain in CRS, including the relationship between pain and sites of CRS. The aim of this study was to investigate whether pain is related to the location of lesions on computed tomography (CT) in CRS. Methods: We analyzed 203 patients who underwent endoscopic sinus surgery (ESS) for 2 years. Patients were assessed using the questionnaires on pain, provided 1 day prior to the operation and 6 months post operation. Sites of CRS were evaluated using CT. We analyzed whether the degree of inflammation in each sinus had an effect on the location of pain. Results: Seventy-eight patients (38.4%) had preoperative facial or head pain. There was no difference in the sinus inflammation scores in CT findings, based on the presence of pain. Pain was most commonly located in the periorbital area, followed by the frontal, vertex, occipital, and facial areas. No significant correlation was found between the sinuses and the location of pain. Conclusions: This study indicates that in CRS patients, several sites of pain are involved, particularly in the periorbital area; these sites were not found to be related to the location of CRS.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/0003489417717268
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2033055-8
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  • 6
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    Nestin Action During Insulin-secreting Cell Differentiation
    SAGE Publications ; 2010
    In:  Journal of Histochemistry & Cytochemistry Vol. 58, No. 6 ( 2010-06), p. 567-576
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 58, No. 6 ( 2010-06), p. 567-576
    Abstract: Nestin, which was initially identified as a marker of neural stem cells, has been reported in regenerating pancreas as well as in early embryonic stem (ES) cell derivatives. However, little is known about its specific roles in stem cells as a functional regulator. We investigated the source of the action of nestin in ES and adult pancreatic ductal stem (PDS) cells in regard to the neogenesis of insulin-secreting β-cells. In ES cells, suppression of nestin by gene silencing led to an increased expression of the pluripotency-associated genes, including Oct 4, Nanog, and SSEA-1, before embryoid body (EB) formation, whereas it reduced endodermal and pancreatic transcription factors in EBs. Inhibition of nestin expression in adult PDS cells caused a low expression of pancreatic transcription factors and islet hormones, leading to poor β-cell development and insulin secretion. These data may indicate not only that nestin is a simple stem cell marker, but also that it constitutes a functional factor at the time of stem cell differentiation. We suggest that nestin plays pivotal roles as an intermediate regulator governing both stemness and differentiation of stem cells in the process of their differentiation into insulin-secreting cells.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/jhc.2010.955682
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 7
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    Cytoprotective Effects of Polyenoylphosphatidylcholine (PPC) on β-cells During Diabetic Induction by Streptozotocin
    SAGE Publications ; 2003
    In:  Journal of Histochemistry & Cytochemistry Vol. 51, No. 8 ( 2003-08), p. 1005-1015
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 51, No. 8 ( 2003-08), p. 1005-1015
    Abstract: Polyenoylphosphatidylcholine (PPC), a phosphatidylcholine-rich phospholipid extracted from soybean, has been reported to protect liver cells from alloxan-induced cytotoxicity. The present study aimed to investigate whether PPC protects pancreatic β-cells from the cytotoxic injury induced by streptozotocin, thus preserving insulin synthesis and secretion. β-Cells of the PPC-treated rats showed a significant reduction of cell death with lesser destruction of plasma membrane on streptozotocin insult. They demonstrated a rapid recovery of GLUT-2 expression, whereas almost irreversible depletion of membranebound GLUT-2 was seen in β-cells of the rats treated with only streptozotocin. A similar cytoprotective effect of PPC was also monitored in the PPC-pretreated MIN6 cells. These β-cells retained their ability to synthesize and secrete insulin and no alteration of glucose metabolism was detected. These results strongly suggest that PPC plays important roles not only in protecting β-cells against cytotoxicity but also in maintaining their insulin synthesis and secretion for normal glucose homeostasis.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/002215540305100804
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 1421306-0
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  • 8
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    The Extract of Edible Alga Petalonia binghamiae Suppresses TGF-β1-or H 2 O 2 -Induced Liver Fibrogenesis in LX-2 and HepG2 Cells
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 6 ( 2018-06), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 6 ( 2018-06), p. 1934578X1801300-
    Abstract: Although the edible alga Petalonia binghamiae is extensively consumed as a health-promoting food by Northeast Asians, little is known about the biomedical efficacies of P. binghamiae. In this report, we investigated the novel efficacy of P. binghamiae extract ( Pb-E01) using LX-2 and HepG2 cells. Pb-E01 inhibited TGF-β1-induced cell proliferation and gene expression in LX-2 cells. In addition, Pb-E01 reduced H 2 O 2 –induced reactive oxygen species (ROS) and alanine aminotransferase (ALT) activity in HepG2 cells. According to these results, we suggest that Pb-E01 plays a functional role in suppressing liver fibrogenesis.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300627
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 9
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    Gait Disturbance Improvement and Cerebral Cortex Rearrangement by Acupuncture in Parkinson’s Disease: A Pilot Assessor-Blinded, Randomized, Controlled, Parallel-Group Trial
    SAGE Publications ; 2020
    In:  Neurorehabilitation and Neural Repair Vol. 34, No. 12 ( 2020-12), p. 1111-1123
    Details
    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 34, No. 12 ( 2020-12), p. 1111-1123
    Abstract: Parkinson’s disease (PD) leads to impaired mobility and limited independence. Objective We investigated the effects of acupuncture on gait disturbance and analyzed hemodynamic changes caused by acupuncture in the cerebral cortex of patients with PD. Methods Participants (n = 26) with gait disturbance due to PD were randomly assigned to the intervention (acupuncture twice a week for 4 weeks + conventional therapy) or control (conventional therapy) groups. We analyzed gait parameters using the GAITRite system and hemodynamic responses in the cerebral cortices using functional near-infrared spectroscopy, Unified Parkinson’s Disease Rating Scale (UPDRS) scores, neurotransmitter levels, as well as the immediate effects of acupuncture in patients with PD. Results The participants tended to walk with hypometric gait (high cadence, short steps) overground. After acupuncture treatment, those in the intervention group showed a significant reduction in cadence and the UPDRS scores involving “walking and balance” compared with those in the control group ( P = .004 and P = .020, respectively); the stride, swing, and single support times were significantly increased ( P = .006, P = .001, and P = .001, respectively). Oxyhemoglobin levels in the intervention group while walking on a treadmill were significantly increased in the prefrontal and supplementary motor areas. The oxyhemoglobin levels in the prefrontal cortex and swing time revealed significant positive correlations. Conclusions Our findings indicated that acupuncture tended to improve hypometric gait and rearranged activation of the cerebral cortex. Thus, acupuncture may be a useful complementary treatment for gait disturbance, including hypometric gait, in patients with PD. Trial Registration Number. Clinical Research Information Service (KCT0002603), https://cris.nih.go.kr/cris/index.jsp
    Type of Medium: Online Resource
    ISSN: 1545-9683 , 1552-6844
    URL: Article
    DOI: 10.1177/1545968320969942
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2100545-X
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  • 10
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    A feasibility study of ballet education using measurement and analysis on partial features of still scenes
    SAGE Publications ; 2016
    In:  International Journal of Distributed Sensor Networks Vol. 12, No. 12 ( 2016-12), p. 155014771668179-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 12, No. 12 ( 2016-12), p. 155014771668179-
    Abstract: There have been a number of dance and ballet education systems using different multimedia devices. One of the well-known multimedia devices is Kinect which uses multiple built-in sensors. We focus on Kinect-based dance and ballet education systems. Existing systems that use Kinect cannot properly recognize the turnout movement. We propose the use of a lower body joint point estimation algorithm and a closest foot points estimation algorithm that can efficiently perform image localization for recognition of basic ballet movements. In addition, in order to evaluate correct ballet movements, we propose a method that extracts partial features from still scenes and performs measurements for knee and foot positions. The proposed method is the first ballet education system that properly measures movements of a ballet dancer.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147716681794
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2192922-1
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