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  • 1
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    Online Resource
    Use of microstructure for visioplasticity analysis
    SAGE Publications ; 1974
    In:  Journal of Strain Analysis Vol. 9, No. 3 ( 1974-07-01), p. 146-151
    Details
    In: Journal of Strain Analysis, SAGE Publications, Vol. 9, No. 3 ( 1974-07-01), p. 146-151
    Abstract: It is often suggested that splitting a specimen and machining grid lines on one of the exposed planes to study flow patterns during plastic deformation interferes with the flow process under investigation. A procedure is described here for flow-function analysis of extrusion specimens in which artificial grid lines are not required. The procedure is restricted to situations in which the microstructure exhibits line segments produced by deforming grains or second-phase particles as they flow through the die. These segments represent partial-flow lines according to the assumptions of flow-function analysis. From numerical analysis of their slopes it is possible to construct the complete flow function. From this, all the kinematic quantities of the deformation can be determined.
    Type of Medium: Online Resource
    ISSN: 0022-4758
    URL: Article
    DOI: 10.1243/03093247V093146
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1974
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  • 2
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    Controlled Laboratory Comparison Study of Motion With Football Equipment in a Destabilized Cervical Spine : Three Spine-Board Transfer Techniques
    SAGE Publications ; 2015
    In:  Orthopaedic Journal of Sports Medicine Vol. 3, No. 9 ( 2015-09-01), p. 232596711560185-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 3, No. 9 ( 2015-09-01), p. 232596711560185-
    Abstract: Numerous studies have shown that there are better alternatives to log rolling patients with unstable spinal injuries, although this method is still commonly used for placing patients onto a spine board. No previous studies have examined transfer maneuvers involving an injured football player with equipment in place onto a spine board. Purpose To test 3 different transfer maneuvers of an injured football player onto a spine board to determine which method most effectively minimizes spinal motion in an injured cervical spine model. Study Design Controlled laboratory study. Methods Five whole, lightly embalmed cadavers were fitted with shoulder pads and helmets and tested both before and after global instability was surgically created at C5-C6. An electromagnetic motion analysis device was used to assess the amount of angular and linear motion with sensors placed above and below the injured segment during transfer. Spine-boarding techniques evaluated were the log roll, the lift and slide, and the 8-person lift. Results The 8-person lift technique resulted in the least amount of angular and linear motion for all planes tested as compared with the lift-and-slide and log-roll techniques. This reached statistical significance for lateral bending ( P = .031) and medial-lateral translation ( P = .030) when compared with the log-roll maneuver. The lift-and-slide technique was significantly more effective at reducing motion than the log roll for axial rotation ( P = .029) and lateral bending ( P = .006). Conclusion The log roll resulted in the most motion at an unstable cervical injury as compared with the other 2 spine-boarding techniques examined. The 8-person lift and lift-and-slide techniques may both be more effective than the log roll at reducing unwanted cervical spine motion when spine boarding an injured football player. Reduction of such motion is critical in the prevention of iatrogenic injury.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/2325967115601853
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 3
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    Gene Expression in First Trimester Preeclampsia Placenta
    SAGE Publications ; 2011
    In:  Biological Research For Nursing Vol. 13, No. 2 ( 2011-04), p. 134-139
    Details
    In: Biological Research For Nursing, SAGE Publications, Vol. 13, No. 2 ( 2011-04), p. 134-139
    Abstract: Background. The goal of this study was to further validate eight candidate genes identified in a microarray analysis of first trimester placentas in preeclampsia. Material and method. Surplus chorionic villus sampling (CVS) specimens of 4 women subsequently diagnosed with preeclampsia (PE) and 8 control women (C) without preeclampsia analyzed previously by microarray and 24 independent additional control samples (AS) were submitted for confirmatory studies by quantitative real-time polymerase chain reaction (qRT-PCR). Results. Downregulation was significant in FSTL3 in PE as compared to C and AS (p = .04). PAEP was downregulated, but the difference was only significant between C and AS (p = .002) rather than between PE and either of the control groups. Expression levels for CFH, EPAS1, IGFBP1, MMP12, and SEMA3C were not statistically different among groups, but trends were consistent with microarray results; there was no anti-correlation. S100A8 was not measurable in all samples, probably because different probes and primers were needed. Conclusions. This study corroborates reduced FSTL3 expression in the first trimester of preeclampsia. Nonsignificant trends in the other genes may require follow-up in studies powered for medium or medium/large effect sizes. qRT-PCR verification of the prior microarray of CVS may support the placental origins of preeclampsia hypothesis. Replication is needed for the candidate genes as potential biomarkers of susceptibility, early detection, and/or individualized care of maternal—infant preeclampsia.
    Type of Medium: Online Resource
    ISSN: 1099-8004 , 1552-4175
    URL: Article
    DOI: 10.1177/1099800410385448
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2070503-7
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  • 4
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    Safety and Efficacy of Extended-Release Niacin for the Treatment of Dyslipidaemia in Patients with HIV Infection: Aids Clinical Trials Group Study A5148
    SAGE Publications ; 2006
    In:  Antiviral Therapy Vol. 11, No. 8 ( 2006-11), p. 1081-1090
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 11, No. 8 ( 2006-11), p. 1081-1090
    Abstract: Dyslipidaemia is very common in patients with HIV infection, but current therapies are often suboptimal. Since niacin may cause insulin resistance and hepatotoxicity, it has generally been avoided in this setting. Methods Non-diabetic male subjects ( n=33) who had well-controlled HIV infection on antiretroviral therapy, fasting triglycerides ≥2.26 mmol/l and non-high density lipoprotein cholesterol (non-HDL-C) ≥4.66 mmol/l received escalating doses of extended-release niacin (ERN) up to 2,000 mg nightly for up to 44 weeks. Results Fourteen subjects (42%) had pre-diabetes at entry. Twenty-three subjects (70%) received the maximum dose, eight (24%) received 1,500 mg. Niacin was well-tolerated. Only four subjects (12%) discontinued study treatment. There were small increases in fasting glycaemia and insulin resistance estimated by the homeostasis model assessment, but insulin resistance measures from the 2-h oral glucose tolerance test only transiently worsened. No subject developed persistent fasting hyperglycaemia; one had persistently elevated 2-h glucose 〉 11.1 mmol/l. There were no significant changes in serum transaminases or uric acid. At week 48, the median change in fasting lipid levels in mmol/l (interquartile range) were: total cholesterol -0.21 (-1.35, -0.05), HDL-C +0.013 (-0.03,+0.28), non-HDL-C -0.49 (-1.37, +0.08) and triglycerides -1.73 (-3.68, -0.72). Favourable changes in large HDL and large very low density lipoprotein particle concentration were observed by nuclear magnetic resonance spectroscopy. Conclusions ERN in doses up to 2,000 mg daily was safe, well-tolerated and efficacious in HIV-infected subjects with atherogenic dyslipidaemia. Increases in glycaemia and insulin resistance tended to be transient.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350601100802
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 5
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    Bovine Fetal Encephalitis and Myocarditis Associated with Protozoal Infections
    SAGE Publications ; 1990
    In:  Veterinary Pathology Vol. 27, No. 5 ( 1990-09), p. 354-361
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 27, No. 5 ( 1990-09), p. 354-361
    Abstract: Bovine fetuses submitted to the California Veterinary Diagnostic Laboratory System were evaluated during a 2-year period (1987 to 1989) for the presence of multifocal necrotizing nonsuppurative encephalitis, nonsuppurative myocarditis, or tissue protozoa. Eighty-two of 445 (18%) fetuses submitted met these histologic criteria. Fetuses were from 54 dairy and two beef herds located throughout the state. In 17 fetuses (21%) protozoa were found in fetal tissues. Protozoa were found in brain parenchyma of ten fetuses (12%), in endothelial cells in four fetuses (5%), in cardiac myofibers in one fetus (1%), and were associated with endothelial cells in two fetuses (2%). In most fetuses there were no significant gross pathologic findings other than autolysis. While aborted fetuses were from 3 to 9 months gestation, the majority were between 5 and 7 months gestation. They were submitted year round, but more were seen in the fall and winter months. Additional salient histologic features included portal nonsuppurative hepatitis, focal hepatic inflammation and necrosis, and focal nonsuppurative myositis. Nonsuppurative inflammation was also found in decreasing frequency, in the adrenal medulla, kidney, mesentery or abdominal fat, placenta, and lung. In two fetuses (Nos. 1 and 2), the location and morphology of the protozoa were compatible with Sarcocystis spp. The identity of protozoa in the remaining 15 fetuses is unknown. The histopathologic changes in these 82 fetuses and the presence of protozoa in 21% of the fetuses suggest these abortions are due to fetal protozoal infections.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/030098589002700508
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1990
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 6
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    Theileriosis in a Missouri Beef Herd Caused by Theileria buffeli : Case Report, Herd Investigation, Ultrastructure, Phylogenetic Analysis, and Experimental Transmission
    SAGE Publications ; 2000
    In:  Veterinary Pathology Vol. 37, No. 1 ( 2000-01), p. 11-21
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 37, No. 1 ( 2000-01), p. 11-21
    Abstract: A 6-year-old Simmental cow infected with Theileria buffeli had a clinical disease characterized by theilerial parasitemia, macrocytic normochromic anemia with acanthocytosis and spherocytosis, lymphoid hyperplasia (lymphocytosis, edematous lymphadenomegaly), dysproteinemia, evidence of liver disease, and a low serum antibody titer against T. buffeli. The cow was in a herd in which all cattle originated in Missouri; 22/75 (29%) of cattle had a theilerial parasitemia and 26/75 (35%) had titers to T. buffeli of ≥1:160. Classification of the Missouri bovine organism as T. buffeli was based on DNA sequencing and comparison to sequences for T. buffeli and Theileria sp. type A obtained from GenBank. Intraerythrocytic veils and piroplasms were seen during transmission electron microscopy. The organism was successfully transmitted to two splenectomized calves, which developed mild anemias while parasitemic. Blood from the second calf was used as the source of T. buffeli antigen for an indirect immunofluorescence antibody test. Theilerial isolates from a Missouri white-tailed deer were also sequenced and resembled Theileria sp. types F and G and were not consistent with the bovine organism.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1354/vp.37-1-11
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 7
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    Neospora -like Protozoal Infections Associated with Bovine Abortions
    SAGE Publications ; 1991
    In:  Veterinary Pathology Vol. 28, No. 2 ( 1991-03), p. 110-116
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 28, No. 2 ( 1991-03), p. 110-116
    Abstract: Eighty bovine fetuses with presumed protozoal infections from a previous 2-year retrospective study were examined by immunohistochemistry using antisera against Neospora caninum. In 66 (83%) of the fetuses, protozoa were found that reacted positively with anti- N. caninum sera. In three (4%) additional fetuses, protozoa identified as Sarcocystis species did not react, and in two fetuses (3%) single protozoal clusters were found only in hematoxylin and cosin-stained slides. A group of 20 fetuses were chosen for further evaluation. They included 14 fetuses from the first group of 80 fetuses plus six additional fetuses that had large numbers of protozoa in the fetal brain. The 20 fetuses were examined immunohistochemically with antisera to N. caninum, Hammondia hammondi, and Toxoplasma gondii. Protozoa from 3/20 fetuses, identified as Sarcocystis species, failed to react with any antisera. In 16/20 fetuses protozoa reacted positively to antisera against N. caninum, and in most cases reacted to H. hammondi, and weakly to one or more of the antisera against T. gondii. Thickwalled protozoal tissue cysts were found in the brain of four of these 16 fetuses by transmissiosn electron microscopy. The cyst wall morphology was comparable to N. caninum. The results suggested that a single protozoal parasite of unknown identity was responsible for most of the bovine abortions. By immunohistochemistry, the unknown protozoon reacted most strongly and consistently to N. caninum antisera, but was antigenically distinct from N. caninum. Ultrastructurally, tissue cysts found in four fetuses most closely resembled Neospora caninum.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/030098589102800202
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1991
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 8
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    Balloon Rupture During Coronary Angioplasty
    SAGE Publications ; 1986
    In:  Angiology Vol. 37, No. 11 ( 1986-11), p. 828-831
    Details
    In: Angiology, SAGE Publications, Vol. 37, No. 11 ( 1986-11), p. 828-831
    Abstract: Out of a total of 1,500 percutaneous coronary angioplasties (PTCA), 55 (3.6%) were associated with balloon rupture. Lesion calcification was noticed in 7 of these 55 patients (12.7%). Balloon rupture occurred at a mean pressure of 10.7 atmospheres. All balloons were retrieved without difficulty. Intimal tears were noted in 18 (32.7%) cases. Three patients required bypass surgery. In 29 patients restudied angiographically, the restenosis rate was 38%. Balloon rupture during PTCA does not seem to be associated with detrimen tal consequences.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/000331978603701106
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1986
    detail.hit.zdb_id: 2065911-8
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  • 9
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    So-Called “Inflammatory Leiomyosarcoma”: A Series of 3 Cases Providing Additional Insights into a Rare Entity
    SAGE Publications ; 2005
    In:  International Journal of Surgical Pathology Vol. 13, No. 2 ( 2005-04), p. 185-195
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 13, No. 2 ( 2005-04), p. 185-195
    Abstract: Inflammatory leiomyosarcoma, a rare entity first described in 1995, has been characterized by smooth muscle differentiation, a near-haploid karyotype, and a surprisingly good prognosis. The morphology is similar to that of conventional leiomyosarcoma admixed with a chronic inflammatory infiltrate. Thus far, only 15 cases have been reported in the English language literature. We report the clinical and pathological features of 3 additional cases of inflammatory leiomyosarcoma. Two women (ages 64 and 25, respectively) and 1 man (age 32) presented with a thigh, ovary, and lung mass, respectively. Inflammatory symptoms, such as anorexia, fever, night sweats, abdominal pain, and diarrhea, coincided with the thigh and ovarian primaries. Immunohistochemical studies revealed diffuse positivity for desmin and poor expression for other smooth muscle and skeletal muscle markers (muscle-specific actin [0/3], α-smooth muscle actin 1/3 [focal] , calponin [1/3], caldesmon [0/3] , and myogenin [0/3]). CD68 was diffusely positive in both the histiocytes and spindle cell component in all cases. Ultrastructural evaluation of 1 case (lung primary) lacked definitive smooth muscle differentiation. Cytogenetic analysis in 1 of 2 cases that were karyotyped, identified a near-haploid karyotype, which has been reported in other cases of inflammatory leiomyosarcoma. The other case showed 2 clonal populations of cells with interstitial deletions of the short arm of chromosome 8 and the long arm of chromosome 9, respectively. The case without cytogenetic data was intimately associated with an ovarian mature teratoma. These data also suggest that inflammatory leiomyosarcoma may lack smooth muscle differentiation, characterized by diffuse immunoreactivity for desmin but lack of immunoreactivity for α-smooth muscle actin, calponin, and caldesmon. In addition, 2 of the 3 cases developed distant metastases to the lungs, which suggests that these lesions may have a worse prognosis than previously believed.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/106689690501300210
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2070102-0
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  • 10
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    Kindergarten Health Assessment Reports: What Do Schools Really Learn from Them?
    SAGE Publications ; 2002
    In:  Clinical Pediatrics Vol. 41, No. 2 ( 2002-03), p. 93-98
    Details
    In: Clinical Pediatrics, SAGE Publications, Vol. 41, No. 2 ( 2002-03), p. 93-98
    Abstract: The kindergarten health assessment report (KHAR), mandated by most states, is used to identify children at school entry with any health problems that may interfere with school performance. The objective of this study was to review the completeness and accuracy of the reports that schools receive from health care providers. By analyzing 3,952 KHARs of children enrolled in the Guilford County (North Carolina) Public Schools during the 1999-2000 school year we found that only 20% were fully completed and only 32% recorded results of all 6 required screening tests. Results of the 3 screening tests most applicable to school readiness: vision, hearing, and developmental screening, were documented only 55% of the time. Providers failed to properly classify 75% of children who were either underweight or overweight. Abnormal vision screening results were noted in 485 (14.2%) children, of whom only 38% were recommended for follow-up. Results of vision and hearing screening were recorded in only 50% of children noted to have developmental concerns. The information recorded on the kindergarten health assessment forms is incomplete and frequently inaccurate. These findings arouse concern, given that these forms constitute the basis for school districts to identify those children who may have medical problems.
    Type of Medium: Online Resource
    ISSN: 0009-9228 , 1938-2707
    URL: Article
    DOI: 10.1177/000992280204100204
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2066146-0
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