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  • 1
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    Online Resource
    Radiological characteristics of Kienböck’s disease in the Korean population
    SAGE Publications ; 2017
    In:  Journal of Orthopaedic Surgery Vol. 25, No. 1 ( 2017-01-01), p. 230949901668443-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 25, No. 1 ( 2017-01-01), p. 230949901668443-
    Abstract: In Kienböck’s disease, the wrist displays certain characteristic radiological parameters, which have been reported to differ among countries. In the present study, we aimed to identify specific radiological parameters of the unaffected wrists in patients with unilateral Kienböck’s disease and to determine the extent of the association of each parameter with the disease in Korea. Methods: This retrospective case–control study assessed the radiological parameters of patients with Kienböck’s disease ( n = 53) and controls ( n = 53), who visited our institution between January 2000 and May 2013. Ulnar variance (UV), radial inclination, lunate fossa inclination, lunate diameter, lunate height, lunate tilting angle (LTA), lunate covering index (LCI), and Ståhl index (SI) were measured and analyzed using a binary logistic regression model. Results: We observed that wrists with a high LTA and LCI, and low UV and SI had a tendency to develop Kienböck’s disease. Conclusion: In the Korean population, a high LTA and LCI, and low UV and SI of the unaffected wrists on plain radiography might be associated with Kienböck’s disease. The radiographic characteristics of the unaffected wrists can differ between patients with unilateral Kienböck’s disease and normal individuals.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499016684436
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2128854-9
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  • 2
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    The Effect of Cubital Tunnel Retinaculum Repair After In Situ Decompression
    SAGE Publications ; 2016
    In:  HAND Vol. 11, No. 1_suppl ( 2016-09), p. 51S-51S
    Details
    In: HAND, SAGE Publications, Vol. 11, No. 1_suppl ( 2016-09), p. 51S-51S
    Abstract: Objective: Cubital tunnel syndrome is the second most frequent nerve entrapment syndrome in upper extremity. Among treatment options, in situ decompression is an effective and safe procedure. However, nerve stretching or subluxation is a potential problem. In this study, we want to identify in situ decompression with cubital tunnel retinaculum repair that can relieve ulnar nerve stretching. Materials and Methods: In total, 35 patients (30 male, 5 female; mean age, 53.1 years) presenting with primary cubital tunnel syndrome operated by in situ decompression with cubital tunnel retinaculum repair were included in the repair group. Twenty-six patients (19 male, 7 female; mean age, 54.6 years) treated with in situ decompression were included in the control group. Intraoperatively in the repair group, the ulnar nerve length (UNL) from intermuscular septum to the first motor branch was measured before and after the cubital tunnel retinaculum repair. Ulnar nerve position at elbow extension and flexion was recorded by ultrasonography postoperative 1 year in both groups. The UNL before and after the retinaculum was analyzed by t test, and ulnar nerve position between the two groups was analyzed by Fisher’s exact test. Results: UNL at elbow extension was not different significantly before and after the retinaculum repair (before repair, 11.4 ± 0.7 cm; after repair, 11.4 ± 0.7 cm), but UNL at elbow flexion was significantly decreased after the retinaculum repair ( P 〈 .001; before repair, 12.5 ± 0.7 cm; after repair, 11.8 ± 0.7 cm). The ulnar nerve position at both extension and flexion was different between groups ( P 〈 .001). Conclusion: UNL was decreased after cubital tunnel retinaculum repair. In situ decompression with cubital tunnel retinaculum repair can be an effective procedure to relieve irritation due to ulnar nerve stretching.
    Type of Medium: Online Resource
    ISSN: 1558-9447 , 1558-9455
    URL: Article
    DOI: 10.1177/1558944716660555cg
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2316440-2
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  • 3
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    The Relationship Between Early Symptom Relief and Surgical Outcomes in Moderate to Severe Cubital Tunnel Syndrome
    SAGE Publications ; 2016
    In:  HAND Vol. 11, No. 1_suppl ( 2016-09), p. 95S-95S
    Details
    In: HAND, SAGE Publications, Vol. 11, No. 1_suppl ( 2016-09), p. 95S-95S
    Abstract: Introduction: Moderate to severe cubital tunnel syndrome usually need surgical treatment. Some patients feel subjective symptom relief shortly after the surgery while others do not. In this study, we want to know whether patients with early symptom relief had different clinical characteristics and surgical outcomes compared with patients without early symptom relief. Materials and Methods: From January 2013 to February 2015, 39 surgical cases with moderate to severe stage cubital tunnel syndrome (Mcgowan grade IIA, IIB, III) were included. In all, 21 patients (17 male, 4 female, mean age 54.6 ± 12.6) reported subjective symptom relief within 14 days from surgery. In addition, 18 patients (16 male, 2 female, mean age 54.7 ± 11.4) did not report early symptom relief. Clinical characteristics including hand dominance, gender, smoking history, type of surgery, age, symptom duration, range of motion, grip strength, key pinch strength, Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) score, and Mcgowan grade were analyzed retrospectively using t test or chi-square test. Surgical outcomes measured at 3 months, 6 months, 12 months after the operation were analyzed using repetitive measured analysis of variance (ANOVA) or chi-square test. Results: The key pinch strength ( P 〈 .001) was different between groups. Postoperative 12 months Krout Wilson criteria ( P = .039) were associated with the early symptom relief. The QuickDASH score and grip strength was improved as time passed, but no difference was observed between groups. Conclusion: Early symptom relief was associated with key pinch strength and surgical outcomes in patients with moderate to severe cubital tunnel syndrome.
    Type of Medium: Online Resource
    ISSN: 1558-9447 , 1558-9455
    URL: Article
    DOI: 10.1177/1558944716660555gb
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2316440-2
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  • 4
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    Results of Multicenter Phase II Study With Imatinib Mesylate in Allogeneic Recipients With Steroid-Refractory Chronic GVHD
    SAGE Publications ; 2022
    In:  Cell Transplantation Vol. 31 ( 2022-01), p. 096368972211137-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 31 ( 2022-01), p. 096368972211137-
    Abstract: In this multicenter phase II study, we evaluated the safety and efficacy of imatinib in patients with steroid-resistant chronic graft-versus-host disease (cGVHD) and evaluated the quality of life (QOL) of the enrolled patients using the Short Form 36 (SF-36) health survey questionnaire. Thirty-six patients who were diagnosed with steroid-refractory cGVHD and treated with imatinib between March 2013 and February 2019 received 100 mg/day of imatinib for 2 weeks. Depending on the patient’s condition and investigator’s decision, the imatinib dose was allowed to be increased by 100 mg every 2 weeks up to 400 mg/day. Patients who achieved stable disease (SD), partial remission (PR), and complete remission (CR) at 3-month response evaluations continued imatinib for up to 6 months. The majority of the patients had multi-organ cGVHD, with skin (63.9%), lungs (44.4%), mouth (38.9%), and eyes (38.9%) as the most common sites. The overall response rate was 58.3%, including 3 and 18 patients with CR and PR, respectively, and an overall decline in National Institutes of Health (NIH) severity scores was observed at study completion in the absence of significant adverse effects. The overall response rates were 70.5%, 66.7%, 34.8%, and 25% in patients with gastrointestinal, liver, skin, and lung cGVHD, respectively. Factors representing emotional well-being were significantly improved based on the patient-reported QOL evaluation using SF-36. The effect of imatinib on steroid tapering, which was notable in responders, was also present in 50% of those who achieved SD without worsening cGVHD. Imatinib exhibited therapeutic efficacy in steroid-refractory and steroid-dependent cGVHD with tolerable toxicity. Clinical Trial Registration: KCT0006785.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897221113789
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2020466-8
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  • 5
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    Treatment of Freiberg Disease with Intra-articular Dorsal Wedge Osteotomy and Absorbable Pin Fixation
    SAGE Publications ; 2007
    In:  Foot & Ankle International Vol. 28, No. 1 ( 2007-01), p. 43-48
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 28, No. 1 ( 2007-01), p. 43-48
    Abstract: Background: The purpose of this study was to evaluate the outcome of intra-articular dorsal wedge osteotomy and absorbable pin fixation for the treatment of Freiberg disease. Methods: From January of 1997, to July of 2003, 12 patients with symptomatic Freiberg disease had intra-articular dorsal wedge osteotomy through the affected metatarsal head fixed with absorbable polyglycolide pins. All 12 patients were women with an average age of 36 (range 16 to 59) years. The Smillie stage of necrosis ranged from II to V. Active range-of-motion exercise was allowed after 4 weeks of short-leg walking cast wear, and weightbearing on the forefoot was allowed after radiographic union was achieved. The mean followup was 45 (range 22 to 84) months. Results: Radiographically, solid healing of all osteotomies was observed at an average of 10 (range 8 to 16) weeks. There was no evidence of displacement, osteolysis, sinus formation, or progression of osteonecrosis at final followup. Pain measurement on a visual analog scale had improved significantly from an average of 8.0 to 2.3 ( p 〈 0.05). The range of motion of the metatarsophalangeal joint increased by a mean of 26 (range 5 to 60) degrees. All patients were satisfied with the results and would have the surgery again. Conclusions: In patients with Freiberg disease, intra-articular dorsal wedge osteotomy restores congruity of the metatarsophalangeal joint, and fixation with absorbable pins provides adequate fixation and avoids a second procedure for implant removal.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.3113/FAI.2007.0008
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2129503-7
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  • 6
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    Two Distinctive Subungual Pathologies: Subungual Exostosis and Subungual Osteochondroma
    SAGE Publications ; 2007
    In:  Foot & Ankle International Vol. 28, No. 5 ( 2007-05), p. 595-601
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 28, No. 5 ( 2007-05), p. 595-601
    Abstract: Background: The purpose of this study was to present features that differentiate subungual exostosis from subungual osteochondroma. Methods: We treated 11 patients for subungual masses. All were confirmed by radiographic and histologic evaluations to be subungual exostosis or subungual osteochondroma. The study patients comprised eight female and three male patients with a mean age at presentation of 18.7 years (range 1.5 to 70.9). In the five patients with subungual exostosis, three (60%) had a toe lesion, and two (40%) had a finger lesion. In the six patients with subungual osteochondroma, four (67%) had a toe lesion, and two (33%) had finger lesions. We analyzed the clinical features, including trauma history, the existence of infection before surgery, tumor recurrence, and postoperative nail deformity. Results: In all patients, the lesions presented as an exophytic tumor of the nail apparatus, beneath the nail plate, which varied in size from 0.6 × 0.4 cm to 1.2 × 0.9 cm. Excision of these masses produced useful toes or fingers without pain, a tender scar, or nail deformity. Although nails were deformed preoperatively, they grew back without ridges or cracks within 3 to 5 months postoperatively. There were no recurrences based on clinical and radiographic evaluations, and both tumor types showed characteristic radiographic and histologic differences. Conclusions: Subungual exostosis and subungual osteochondroma are benign but have distinct osseous pathologies. We concluded that subungual exostosis is clinically, developmentally, radiographically, and histologically distinct from subungual osteochondroma.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.3113/FAI.2007.0595
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2129503-7
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  • 7
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    Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases
    SAGE Publications ; 2021
    In:  Multiple Sclerosis Journal Vol. 27, No. 6 ( 2021-05), p. 964-967
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 27, No. 6 ( 2021-05), p. 964-967
    Abstract: We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458520948213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008225-3
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  • 8
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    FOLFIRINOX in borderline resectable and locally advanced unresectable pancreatic adenocarcinoma
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592095329-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592095329-
    Abstract: Despite the scarcity of data based on randomized trials, FOLFIRINOX is widely used in the management of borderline resectable pancreatic cancer (BRPC) and locally advanced unresectable pancreatic cancer (LAPC). We investigated the clinical outcomes of neoadjuvant FOLFIRINOX in patients with BRPC and LAPC. Methods: This single-center retrospective analysis included a total of 199 consecutive patients with BRPC or LAPC who received conventional or modified FOLFIRINOX between February 2013 and January 2017. An independent radiologist reviewed all baseline computed tomography or magnetic resonance imaging scans were reviewed for vascular invasion status. Results: With median follow-up duration of 40.3 months [95% confidence interval (CI), 36.7–43.8] in surviving patients, median progression-free survival (PFS) and overall survival (OS) were 10.6 (95% CI, 9.5–11.7) and 18.1 (95% CI, 16.0–20.3) months, respectively. The 1-year PFS rate was 66.0% (95% CI, 65.3–66.7%), and the 2-year OS rate was 37.2% (95% CI, 36.5–37.9%). PFS and OS did not differ between BRPC and LAPC groups [median PFS, 11.1 months (95% CI, 8.8–13.5) versus 10.1 months (95% CI, 8.4–11.8), p = 0.47; median OS, 18.4 months (95% CI, 16.1–20.8) versus 17.1 months (95% CI, 13.2–20.9), p = 0.50] . Curative-intent conversion surgery (R0/R1) was performed in 63 patients (31.7%). C•A 19-9 response, objective tumor response to FOLFIRINOX, and conversion surgery were independent prognostic factors for OS. Conclusion: FOLFIRINOX was effective for management of BRPC and LAPC. Given the potential for cure, a significant proportion of patients can undergo conversion curative-intent surgery following FOLFIRINOX.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920953294
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 9
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    Prognostic implications of hepatitis B virus infection in intrahepatic cholangiocarcinoma treated with first-line gemcitabine plus cisplatin
    SAGE Publications ; 2018
    In:  The International Journal of Biological Markers Vol. 33, No. 4 ( 2018-11), p. 432-438
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 33, No. 4 ( 2018-11), p. 432-438
    Abstract: Hepatitis B virus infection is a well-known risk factor for intrahepatic cholangiocarcinoma. However, its prognostic impact has rarely been investigated in advanced intrahepatic cholangiocarcinoma. Methods: Between April 2010 and May 2015, 296 patients with unresectable or metastatic intrahepatic cholangiocarcinoma who received gemcitabine plus cisplatin (GemCis) were categorized into a hepatitis B virus group (n=62; 21%) and a non-hepatitis B virus group (n=234; 79%). Clinicopathological features and survival outcomes were retrospectively reviewed and analyzed. Results: The median age of patients was 59 years (range, 27–78). The median overall survival with first-line GemCis was 9.4 months (95% CI 8.4, 10.4). Compared to the non-hepatitis B virus group, the hepatitis B virus group was younger (median age, 57 vs. 61 years, P = 0.001), mainly male (74% vs. 57%, P = 0.02), and had lower frequency of elevated cancer antigen (CA) 19-9 (34% vs. 59%, P = 0.001) and alkaline phosphatase (43% vs. 61%, P = 0.01). In a univariate analysis, the hepatitis B virus infection showed a marginal relationship with poor overall survival compared to the non-hepatitis B virus infection (median, 8.3 vs. 10.0 months; P=0.13). A multivariate analysis of potential prognostic factors revealed a significant association with poor overall survival in the hepatitis B virus group (hazard ratio (HR) =1.50, P = 0.02). Initial metastatic disease (vs. recurrent/unresectable disease; HR=1.50), metastatic sites ⩾ 2 (vs. 0–1; HR=1.51), Eastern Cooperative Oncology Group performance status ⩾ 2 (vs. 0–1; HR=1.93), elevated total bilirubin (vs. normal; HR=1.83), and low albumin (vs. normal; HR=1.52) were significantly related to an unfavorable overall survival. Conclusions: This study suggests that the hepatitis B virus infection may be associated with distinctive clinicopathological characteristics and poor outcome in advanced intrahepatic cholangiocarcinoma treated with GemCis.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.1177/1724600818777239
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1475778-3
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  • 10
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    Anti-oxidative Fraction of Lycorma delicatula Alleviates Inflammatory Indicators
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 4 ( 2018-04), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 4 ( 2018-04), p. 1934578X1801300-
    Abstract: Lycorma delicatula is a reluctant pest capable of living in the stems of several tree species. The population has recently expanded in Korea due to several environmental factors including climate change. However, the precise reasons for this rapid and drastic increase in population size remain unknown. In order to examine the potential utility of this surplus biomass of Lycorma delicatula, we prepared an aqueous fraction from a dried imago, and tested its various anti-inflammatory activities and effects on cytokine levels in lipopolysaccharide (LPS)-activated RAW264.7 cells. The aqueous extract of Lycorma delicatula showed potent inhibitory activity on nitric oxide production, by more than 60% at a concentration of 300 μg/mL. We also evaluated interleukin (IL)-13 level using enzyme-linked immunosorbent assays (ELISAs). The anti-oxidative fraction of Lycorma delicatula inhibited LPS-induced IL-13 production in a dose-dependent manner, and T-bet promoter activity of cells treated with 300 μg/mL of Lycorma delicatula extract was also dramatically inhibited to 62% of that of LPS-treated cells. Furthermore, we compared matrix metalloproteinase-7 (MMP-7), -9, -14 and -17 expressions using reverse transcription-polymerase chain reaction (RT-PCR), which showed a drastic decrease in RNA levels in cells treated with the anti-oxidative fraction. Together, the present results suggest that the aqueous fraction of Lycorma delicatula has potential to ameliorate inflammatory characteristics during an inflammation event, supporting the idea that the fraction may be applied as a biomaterial to prevent inflammatory damage in skin tissues.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300413
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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