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  • SAGE Publications  (67)
  • 1
    Online Resource
    Online Resource
    Differential Expression of PAI-RBP1, C1orf142, and COTL1 in Non–Small Cell Lung Cancer Cell Lines with Different Tumor Metastatic Potential
    SAGE Publications ; 2012
    In:  Journal of Investigative Medicine Vol. 60, No. 4 ( 2012-04), p. 689-694
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 60, No. 4 ( 2012-04), p. 689-694
    Abstract: Human non–small cell lung cancer (NSCLC) is one of the most common malignancies in the modern world. Its recurrence is mainly due to its ability to invade and metastasize. However, the precise mechanism for tumor development and metastasis is still not fully understood. To shed light on the development of lung cancer, the human giant cell lung carcinoma cell lines 95D with high metastatic potential and 95C with low metastatic potential were selected in this study. The 2 cell lines originated from the same parental cell and share a similar genetic background. In the current study, we identified 3 differentially expressed proteins in 95C and 95D cell lines, namely, PAI-RBP1, C1orf142, and COTL1, by using 2-dimensional electrophoresis proteomics analysis. We found that PAI-RBP1 and C1orf142 expression levels were higher in 95D than in 95C cells, whereas COTL1 expression level was lower in 95D when compared to 95C cells. We also confirmed these results by reverse transcription–polymerase chain reaction and immunoblotting analyses. The messenger RNA and protein levels of PAI-RBP1 and C1orf142 were much higher in 95D than in 95C cells, and COTL1 expression level was lower in 95D than in 95C cells. The PAI-RBP1 expression was assessed by immunohistochemistry in 70 NSCLC and 7 normal lung tissue samples from patients. PAI-RBP1 expression level was higher in tumor tissues (positive staining in 87.1% of cases [61/70]) than in normal tissues (positive staining in 14.3% of cases [1/7] ). In conclusion, by studying protein expression in NSCLC cell lines with high and low metastasis as well as in human lung cancer tissues, we have identified 3 proteins, namely, PAI-RBP1, C1orf142, and COTL1, which were differentially expressed in NSCLC cell lines with different metastatic potential. In addition, we also found that PAI-RBP1 might contribute to NSCLC development.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.2310/JIM.0b013e31824963b6
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
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  • 2
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    The Use of Vibrothermography for Detecting and Sizing low Energy Impact Damage of Cfrp Laminate
    SAGE Publications ; 2017
    In:  Advanced Composites Letters Vol. 26, No. 5 ( 2017-09), p. 096369351702600-
    Details
    In: Advanced Composites Letters, SAGE Publications, Vol. 26, No. 5 ( 2017-09), p. 096369351702600-
    Abstract: The detection and evaluation of low energy impact damage of carbon fibre reinforced polymer (CFRP) laminate were investigated using vibrothermography. To this goal, four specimens were begun with low energy impact with different energies, followed by the detection using vibrothermography. The detection results show that the matrix crack is mainly located closer to the surface opposite to impact, while the delamination is mainly closer to the impact surface. Then, an iterative algorithm based on maximal entropy theory was proposed for thermal image segmentation and on this basis, the damaged area was determined. The obtained results show the damaged area increases with the increase of impact energy and the damaged area and impact energy may present an approximate linear relationship.
    Type of Medium: Online Resource
    ISSN: 2633-366X , 2633-366X
    URL: Article
    DOI: 10.1177/096369351702600504
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 3053419-7
    detail.hit.zdb_id: 2144398-1
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  • 3
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    With Guide of Spike-in Experiment for Optimizing Workflow of LC-MS data Processing in Metabolomics
    SAGE Publications ; 2017
    In:  Natural Product Communications Vol. 12, No. 8 ( 2017-08), p. 1934578X1701200-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 12, No. 8 ( 2017-08), p. 1934578X1701200-
    Abstract: A systematical study was performed to investigate the processing workflow of LC-MS-based metabolomics data by optimizing parameter settings in XCMS software and comparing different preprocessing methods. Here we use a spike-in experiment combining with design of experiment (DoE) approaches for optimizing XCMS software parameters. A trusted index, which was based on accuracy evaluation of the spike-in data, was employed to assess the optimizing process. After optimizing the XCMS setting, the trusted index was improved from 3.67 to 30 and positive rate of spike-in standards also increased from 20% to 100%. Moreover, different data preprocessing methods, such as normalization, different scaling methods were also investigated on spike-in data since they were found to affect the outcome of the data analysis and ions features identification. Accordingly, UN-normalization and Pareto scaling were chosen as appropriate preprocessing methods to deal with LC-MS data through the evaluation of match index (mainly applied multivariate statistics methods). Finally, the optimized workflow was applied to experimental samples that acquired from metabolomics experiment and analyzed randomly with spike-in sample, which indicated a better applicability in formal metabolomics experiment. It is concluded that the proposed data processing workflow could be used as feasible approach for improving the quality of LC-MS-based metabolomics data and ensured the veracity of metabolites identification in data processing procedures to a certain extent.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1701200837
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 4
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    PAX—FKHR Fusion Genes and AChR-γ in Chinese Patients With Rhabdomyosarcoma: Diagnosis Using Formalin-Fixed Archival Tissues
    SAGE Publications ; 2009
    In:  International Journal of Surgical Pathology Vol. 17, No. 1 ( 2009-02), p. 6-15
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 17, No. 1 ( 2009-02), p. 6-15
    Abstract: The majority of alveolar RMSs have t(2;13)(q35;q14) or (1:13)(p36;q14),which generate PAX3/7 -FKHR fusion genes. Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR. PAX3 -FKHR and PAX7-FKHR transcripts were positive in 4/8 and 2/8 cases of ARMS, respectively. 9 ERMSs and 26 other SRCTs were negative for PAX3/7-FKHR. In addition, AChR-γ and AChR-α mRNA were detected by semiquantitative duplex PCR in above cases and 3 normal muscles. 17 RMSs were found to have overexpression of AChR-γ, with an AChR-γ/-α ratio of ≥1; 3 cases of normal muscle had very weak AChR-γ expression, with an AChR- γ/-α ratio of 〈 1. AChR-γ transcripts were not detectable in all 26 other SCRTs. The results demonstrated that detection of PAX3/7-FKHR fusion gene by one-step RT-PCR is useful in the diagnosis of RMS and that AChR-γ is overexpressed in Chinese RMS patients.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/1066896908323922
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2070102-0
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  • 5
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    Influences of off-sized rollers on mechanical performance of spherical roller bearings
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics Vol. 229, No. 4 ( 2015-12), p. 344-356
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics, SAGE Publications, Vol. 229, No. 4 ( 2015-12), p. 344-356
    Abstract: Based on a set of formulae for calculating elliptical contact parameters and elastic deformation developed by Houpert and mechanical analysis, a numerical model is established for calculating the roller load distribution and shaft axis orbit of spherical roller bearings with considering off-sized rollers in this paper. A numerical calculation example is carried out to investigate the effects of single off-sized roller and multiple off-sized rollers on spherical roller bearing roller load distribution and axis orbit. Results show that the roller maximum load will increase as its off-sized diameter becomes larger than the nominal diameter, and the roller maximum load will decrease as its off-sized diameter is smaller than the nominal diameter. The maximum loads of the rollers in the two rows neighboring on the off-sized roller/rollers can also be affected. Meanwhile, roller diameter error will largely affect the axis orbit and inner ring radial displacement of spherical roller bearings.
    Type of Medium: Online Resource
    ISSN: 1464-4193 , 2041-3068
    URL: Article
    DOI: 10.1177/1464419314566086
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2032771-7
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  • 6
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    Local anesthesia combined with intra-articular ropivacaine can provide satisfactory pain control in ankle arthroscopic surgery: A retrospective cohort study
    SAGE Publications ; 2020
    In:  Journal of Orthopaedic Surgery Vol. 28, No. 2 ( 2020-01-01), p. 230949902093812-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 28, No. 2 ( 2020-01-01), p. 230949902093812-
    Abstract: Local anesthesia (LA) is widely used in knee arthroscopic surgery but not in ankle arthroscopy. Objective: To understand the effectiveness and safety of LA combined with ropivacaine in pain control for ankle arthroscopy. Study Design: Retrospective cohort. Methods: We retrospectively collected data for patients who underwent ankle arthroscopy from April 2012 to April 2017. Patients were grouped by anesthesia method: LA, LA with ropivacaine (LA+R), spinal anesthesia (SA), and SA with ropivacaine (SA+R). Intra- and postoperative visual analog scale (VAS) scores, complications, doses of supplemental pain medication, hospitalization cost and duration, and satisfaction with pain control during hospitalization were analyzed. Results: The study included 276 patients (LA: 93; LA+R: 124; SA: 31; SA+R: 28). The LA and LA+R groups had significantly higher intraoperative VAS scores (LA vs. SA, p = 0.001; LA vs. SA+R, p = 0.002; LA+R vs. SA, p = 0.00; LA+R vs. SA+R, p = 0.00), but fewer complications, than the SA and SA+R groups. The LA+R and SA+R groups had significantly better outcomes for postoperative pain control (LA vs. LA+R, p = 0.01; LA vs. SA+R, p = 0.01; SA vs. SA+R, p = 0.01; SA vs. LA+R, p = 0.03) and required less supplemental pain medication. Hospitalization cost was lower and duration shorter in the LA and LA+R groups than in the SA and SA+R groups. There was no significant difference in satisfaction among the four groups. Limitations: This was a single-center retrospective and relatively short-term study. Conclusions: LA+R which could be safely applied in ankle arthroscopy provided satisfactory pain control, reduced postoperative pain intensity, fewer complications, shorter hospital stay, and good cost-effectiveness. It can be safely applied in ankle arthroscopy for the specific patients with ankle osteoarthritis.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499020938122
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2128854-9
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  • 7
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    Finite strip-Riccati transfer matrix method for buckling analysis of tree-branched cross-section thin-walled members
    SAGE Publications ; 2022
    In:  Advances in Mechanical Engineering Vol. 14, No. 3 ( 2022-03), p. 168781322210827-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 14, No. 3 ( 2022-03), p. 168781322210827-
    Abstract: Thin-walled components are gaining wide application in the field of modern engineering structures. The buckling analysis of thin-walled structures has thus become an important research topic. Here, we developed a new method named as finite strip-Riccati transfer matrix method (Riccati FSTMM) for buckling analysis of tree-branched cross-section thin-walled members. The method integrates Riccati transfer matrix method (Riccati TMM) for tree multi-body system with semi-analytical finite strip method (SA-FSM). Compared to SA-FSM, Riccati FSTMM features a smaller matrix and higher calculation efficiency, with no need for global stiffness matrix. In addition, by arranging uniformly distributed middle nodal lines inside strip elements, we developed the high order finite strip-Riccati transfer matrix method (Riccati HFSTMM) for buckling analysis of tree-branched cross-section thin-walled members. This method further improves the efficiency and accuracy of Riccati FSTMM. We tested the two proposed methods with two numerical examples, and demonstrated their superior reliability and efficiency over the finite element method (FEM).
    Type of Medium: Online Resource
    ISSN: 1687-8132 , 1687-8140
    URL: Article
    DOI: 10.1177/16878132221082764
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2501620-9
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  • 8
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    Who Can Get More Benefits? Effects of Mindfulness Training in Long-Term and Short-Term Male Prisoners
    SAGE Publications ; 2019
    In:  International Journal of Offender Therapy and Comparative Criminology Vol. 63, No. 13 ( 2019-10), p. 2318-2337
    Details
    In: International Journal of Offender Therapy and Comparative Criminology, SAGE Publications, Vol. 63, No. 13 ( 2019-10), p. 2318-2337
    Abstract: The aim of the present study was to examine the effects of a 6-week mindfulness training program on mental health, anxiety, depression, aggression, sleep quality, mood states, total mood disturbance, and perceived stress among male Chinese prisoners, and to explore whether the intervention effects differed in long-term and short-term prisoners. Eighty-three male prisoners completed the study, including 39 in the mindfulness training group and 44 in the waitlist control group. Results showed that, compared with the waitlist control group, mindfulness training group showed a significant improvement in mindfulness level ( p 〈 .0l), Symptom Checklist-90 (SCL-90; p 〈 .00l), aggression ( p 〈 .05), sleep quality ( p 〈 .05), and total mood disturbance ( p 〈 .0l). Moreover, compared with the short-term prisoners, mindfulness training was more effective on the long-term prisoners in mindfulness level ( p 〈 .05), SCL-90 ( p 〈 .001), anxiety ( p 〈 .05), depression ( p 〈 .05), aggression ( p 〈 .05), total mood disturbance ( p 〈 .0l), and perceived stress ( p 〈 .0l). Given the study’s innovation, we discussed its significance and limitations.
    Type of Medium: Online Resource
    ISSN: 0306-624X , 1552-6933
    URL: Article
    DOI: 10.1177/0306624X19846771
    RVK:
    PH 178
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2034467-3
    SSG: 2
    SSG: 2,1
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  • 9
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    Coping strategies as mediators in the relation between perceived social support and job burnout among Chinese firefighters
    SAGE Publications ; 2022
    In:  Journal of Health Psychology Vol. 27, No. 2 ( 2022-02), p. 363-373
    Details
    In: Journal of Health Psychology, SAGE Publications, Vol. 27, No. 2 ( 2022-02), p. 363-373
    Abstract: Perceived social support is a known factor in preventing job burnout in many professions. However, the influence of coping strategies on perceived social support and job burnout remains unclear. The current study investigated firefighters using data from a two-wave study to fill this gap in knowledge. Chinese firefighters ( N = 340) participated in the study for 3-months. Results indicated that perceived social support at baseline predicted job burnout at the 3-month follow-up through coping strategies. We concluded that perceived social support acts through positive coping strategies to reduce job burnout in Chinese firefighters.
    Type of Medium: Online Resource
    ISSN: 1359-1053 , 1461-7277
    URL: Article
    DOI: 10.1177/1359105320953475
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2021897-7
    SSG: 5,2
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  • 10
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    Prognostic implication of noninvasive right ventricle-to-pulmonary artery coupling in chronic thromboembolic pulmonary hypertension
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Chronic Disease Vol. 13 ( 2022-01), p. 204062232211028-
    Details
    In: Therapeutic Advances in Chronic Disease, SAGE Publications, Vol. 13 ( 2022-01), p. 204062232211028-
    Abstract: Impairment of right ventricle-to-pulmonary artery coupling (RV-PA coupling) is a major determinant of poor prognosis in patients with pulmonary hypertension. This study sought to evaluate the ability of an echo-derived metric of RV-PA coupling, the ratio between tricuspid annular plane systolic excursion (TAPSE), and pulmonary artery systolic pressure (PASP) and to predict adverse clinical outcomes in chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results: A total of 205 consecutive patients with confirmed CTEPH were retrospectively recruited from Fuwai Hospital between February 2016 and November 2020. Baseline echocardiography, right heart catheterization, and cardiopulmonary exercise testing were analyzed. Patients with lower TAPSE/PASP had a significantly compromised echocardiographic and hemodynamic status and exercise capacity at baseline. The TAPSE/PASP ratio correlated significantly with hemodynamic parameters, including pulmonary vascular resistance ( r = −0.48, p  〈  0.001) and pulmonary arterial compliance ( r = 0.45, p  〈  0.001). During a median period of 1-year follow-up, 63 (30.7%) patients experienced clinical worsening. The relationship between TAPSE/PASP and clinical worsening was assessed using different multivariate Cox regression models. After adjustment for a series of previously screened independent predictors, TAPSE/PASP remained significantly associated with outcomes, and the hazard ratio (per standard deviation increase) of the final model was 0.402. Conclusion: In patients with CTEPH, baseline RV-PA coupling measured as the TAPSE/PASP ratio is associated with disease severity and adverse outcomes. A low TAPSE/PASP identifies patients with a high risk of clinical deterioration, and this novel metric could be applicable for risk stratification in CTEPH.
    Type of Medium: Online Resource
    ISSN: 2040-6223 , 2040-6231
    URL: Article
    DOI: 10.1177/20406223221102803
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2554816-5
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