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  • 1
    Online Resource
    Online Resource
    Minimizing Tour Operators' Exposure to Lawsuits
    SAGE Publications ; 1997
    In:  Cornell Hotel and Restaurant Administration Quarterly Vol. 38, No. 2 ( 1997-04), p. 20-24
    Details
    In: Cornell Hotel and Restaurant Administration Quarterly, SAGE Publications, Vol. 38, No. 2 ( 1997-04), p. 20-24
    Abstract: Travel generally and group tours particularly have never been bigger businesses than they are today. But at the same time, never have tourists been more at risk for personal injury from a host of causes, including their own activities. To the tour operator, those risks can add up to a large potential liability if a guest is hurt during a tour. Potential liability arises from three sources. First, if the tour operator maintains control of (or actually owns) the vendor in whose care the guest is injured, the tour operator may be held liable. In most cases, the tour operator is merely packaging the services of independent third-party vendors, so control is rarely an issue. Second, if guests determine that the tour operator's descriptive brochures and collateral material created a false sense of security regarding the trip, those guests could then sue if they are hurt. Tour operators should therefore review their publications to ensure that they do not imply that the guest cannot be hurt while on the tour. Finally, if the tour operator is aware of potential danger in a given destination and fails to warn its customers of possible crime or other threat, that tour operator could be liable for any injury to the guest. As a closing note, tour operators must be aware of the variations in law in different countries. An action that would not be a tort, say, in the United States may be considered as such in another country.
    Type of Medium: Online Resource
    ISSN: 0010-8804
    URL: Article
    DOI: 10.1177/001088049703800220
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
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  • 2
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    Chordomas at High Prevalence in the Captive Population of the Endangered Perdido Key Beach Mouse ( Peromyscus polionotus trissyllepsis )
    SAGE Publications ; 2016
    In:  Veterinary Pathology Vol. 53, No. 1 ( 2016-01), p. 163-169
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 53, No. 1 ( 2016-01), p. 163-169
    Abstract: The Perdido Key beach mouse ( Peromyscus polionotus trissyllepsis) is a critically endangered subspecies of the oldfield mouse. The captive population, currently maintained by 3 Florida zoos, is entirely derived from just 3 wild-caught ancestor mice. Necropsy and histopathology revealed chordoma of the vertebral column in 38 of 88 (43%) mice. The tumors were locally expansile and invasive masses of large physaliferous (vacuolated) cells with small, round, hyperchromatic nuclei, similar to the “classic” form of chordomas described in humans. Primary tumors rarely contained small amounts of bone and cartilaginous matrix, characteristic of the “chondroid” form. Neoplastic cells contained abundant granules positive by the periodic acid–Schiff reaction. Brachyury and cytokeratin AE1/AE3 were detected in neoplastic cells by immunohistochemistry, but uncoupling protein 1 was not identified. Primary tumors occurred along the entire vertebral column—cervical, 5 of 38 (13%); thoracic, 16 (42%); lumbar, 13 (34%); and sacral, 10 (26%)—and 10 (26%) mice had multiple primary masses. Metastases to the lungs were noted in 13 of the 38 (34%) mice. Mice diagnosed with chordomas postmortem ranged from 424 to 2170 days old, with a mean of 1399 days. The prevalence of chordoma was not significantly different between males ( n = 23 of 50; 46%) and females ( n = 15 of 38; 39%).
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/0300985815575051
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 3
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    The Stroke Riskometer™ App: Validation of a Data Collection Tool and Stroke Risk Predictor
    SAGE Publications ; 2015
    In:  International Journal of Stroke Vol. 10, No. 2 ( 2015-02), p. 231-244
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 10, No. 2 ( 2015-02), p. 231-244
    Abstract: The greatest potential to reduce the burden of stroke is by primary prevention of first-ever stroke, which constitutes three quarters of all stroke. In addition to population-wide prevention strategies (the ‘mass’ approach), the ‘high risk’ approach aims to identify individuals at risk of stroke and to modify their risk factors, and risk, accordingly. Current methods of assessing and modifying stroke risk are difficult to access and implement by the general population, amongst whom most future strokes will arise. To help reduce the burden of stroke on individuals and the population a new app, the Stroke Riskometer™, has been developed. We aim to explore the validity of the app for predicting the risk of stroke compared with current best methods. Methods 752 stroke outcomes from a sample of 9501 individuals across three countries (New Zealand, Russia and the Netherlands) were utilized to investigate the performance of a novel stroke risk prediction tool algorithm (Stroke Riskometer™) compared with two established stroke risk score prediction algorithms (Framingham Stroke Risk Score [FSRS] and QStroke). We calculated the receiver operating characteristics (ROC) curves and area under the ROC curve (AUROC) with 95% confidence intervals, Harrels C-statistic and D-statistics for measure of discrimination, R 2 statistics to indicate level of variability accounted for by each prediction algorithm, the Hosmer-Lemeshow statistic for calibration, and the sensitivity and specificity of each algorithm. Results The Stroke Riskometer™ performed well against the FSRS five-year AUROC for both males (FSRS = 75·0% (95% CI 72·3%–77·6%), Stroke Riskometer™ = 74·0(95% CI 71·3%–76·7%) and females [FSRS = 70·3% (95% CI 67·9%–72·8%, Stroke Riskometer™ = 71·5% (95% CI 69·0%–73·9%)], and better than QStroke [males–59·7% (95% CI 57·3%–62·0%) and comparable to females = 71·1% (95% CI 69·0%–73·1%)] . Discriminative ability of all algorithms was low (C-statistic ranging from 0·51–0·56, D-statistic ranging from 0·01–0·12). Hosmer-Lemeshow illustrated that all of the predicted risk scores were not well calibrated with the observed event data ( P 〈 0·006). Conclusions The Stroke Riskometer™ is comparable in performance for stroke prediction with FSRS and QStroke. All three algorithms performed equally poorly in predicting stroke events. The Stroke Riskometer™ will be continually developed and validated to address the need to improve the current stroke risk scoring systems to more accurately predict stroke, particularly by identifying robust ethnic/race ethnicity group and country specific risk factors.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1111/ijs.12411
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2211666-7
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  • 4
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    Coping Matters: An Examination of Coping Among Black Americans During COVID-19
    SAGE Publications ; 2022
    In:  The Counseling Psychologist Vol. 50, No. 3 ( 2022-04), p. 384-414
    Details
    In: The Counseling Psychologist, SAGE Publications, Vol. 50, No. 3 ( 2022-04), p. 384-414
    Abstract: Using a critical race theory framework and a convergent mixed-method design, this study examined the relationship between coping with stress and psychological distress among Black U.S. Americans ( N = 155) during the COVID-19 pandemic in the context of race-based stressors (e.g., anti-Black racism). Path analysis revealed mixed support for hypotheses; avoidant coping was positively related to all measured facets of psychological distress, whereas socially supported coping was associated with none. Self-sufficient coping was negatively associated with only depressive symptoms. Qualitative analysis revealed four salient themes: (a) Race and the COVID-19 Pandemic, (b) Complex Pandemic Related Changes to Life, (c) Emotional Responses to the Pandemic, and (d) Coping with the COVID Pandemic. These themes suggested the pandemic disrupted participants’ ability to engage in, or effectively use, typically adaptive coping strategies and distress was exacerbated by fears for the safety of other Black U.S. Americans. Implications for training, practice, research, and advocacy are discussed.
    Type of Medium: Online Resource
    ISSN: 0011-0000 , 1552-3861
    URL: Article
    DOI: 10.1177/00110000211069598
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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    SSG: 5,2
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  • 5
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    The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description
    SAGE Publications ; 2015
    In:  Journal of Psychopharmacology Vol. 29, No. 9 ( 2015-09), p. 943-960
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 29, No. 9 ( 2015-09), p. 943-960
    Abstract: Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention and therefore a pressing need for further study of brain mechanisms underpinning relapse circuitry. The Imperial College Cambridge Manchester (ICCAM) platform study is an experimental medicine approach to this problem: using functional magnetic resonance imaging (fMRI) techniques and selective pharmacological tools, it aims to explore the neuropharmacology of putative relapse pathways in cocaine, alcohol, opiate dependent, and healthy individuals to inform future drug development. Addiction studies typically involve small samples because of recruitment difficulties and attrition. We established the platform in three centres to assess the feasibility of a multisite approach to address these issues. Pharmacological modulation of reward, impulsivity and emotional reactivity were investigated in a monetary incentive delay task, an inhibitory control task, and an evocative images task, using selective antagonists for µ-opioid, dopamine D3 receptor (DRD3) and neurokinin 1 (NK1) receptors (naltrexone, GSK598809, vofopitant/aprepitant), in a placebo-controlled, randomised, crossover design. In two years, 609 scans were performed, with 155 individuals scanned at baseline. Attrition was low and the majority of individuals were sufficiently motivated to complete all five sessions ( n=87). We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881115596155
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2028926-1
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  • 6
    Online Resource
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    A condition resembling pagetoid reticulosis in a laboratory mouse
    SAGE Publications ; 1991
    In:  Laboratory Animals Vol. 25, No. 2 ( 1991-04-01), p. 153-155
    Details
    In: Laboratory Animals, SAGE Publications, Vol. 25, No. 2 ( 1991-04-01), p. 153-155
    Abstract: A raised, hairless cutaneous nodule was found incidentally at necropsy of a 24-month-old CD1 mouse. Histologically there was infiltration of the epidermis by a monomorphic population of moderate to large lymphocytoid cells. Many large cells had bizarre convolutions of the nuclear membrane and resembled the so-called Sézary or mycosis cells seen in epidermotropic T-cell proliferative disorders. The pattern of cutaneous involvement and the presence of the large cells with convoluted nuclei is characteristic of pagetoid reticulosis. No previous reports of such cutaneous lymphoid neoplasms in mice were found in an extensive literature search.
    Type of Medium: Online Resource
    ISSN: 0023-6772 , 1758-1117
    URL: Article
    DOI: 10.1258/002367791781082450
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1991
    detail.hit.zdb_id: 2036511-1
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  • 7
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    International Preferences in Selecting Mates : A Study of 37 Cultures
    SAGE Publications ; 1990
    In:  Journal of Cross-Cultural Psychology Vol. 21, No. 1 ( 1990-03), p. 5-47
    Details
    In: Journal of Cross-Cultural Psychology, SAGE Publications, Vol. 21, No. 1 ( 1990-03), p. 5-47
    Abstract: This study sought to identify the effects of culture and sex on mate preferences using samples drawn world-wide. Thirty-seven samples were obtained from 33 countries located on six continents and five islands (N = 9,474). Hierarchical multiple regressions revealed strong effects of both culture and sex, moderated by specific mate characteristics. Chastity proved to be the mate characteristic on which cultures varied the most. The preference ordering of each sample was contrasted with an international complement. Each culture displayed a unique preference ordering, but there were some similarities among all cultures as reflected in a positive manifold of the cross-country correlation matrix. Multidimensional scaling of the cultures yielded a five dimensional solution, the first two of which were interpreted. The first dimension was interpreted as Traditional versus Modern, with China, India, Iran, and Nigeria anchoring one end and the Netherlands, Great Britain, Finland, and Sweden anchoring the other. The second dimension involved valuation of education, intelligence, and refinement. Consistent sex differences in value attached to eaming potential and physical attractiveness supported evolution-based hypotheses about the importance of resources and reproductive value in mates. Discussion emphasizes the importance of psychological mate preferences for scientific disciplines ranging from evolutionary biology to sociology.
    Type of Medium: Online Resource
    ISSN: 0022-0221 , 1552-5422
    URL: Article
    DOI: 10.1177/0022022190211001
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1990
    detail.hit.zdb_id: 2021892-8
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    SSG: 5,2
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  • 8
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    Physical Test for Distant Metastases in Patients with Breast Cancer
    SAGE Publications ; 1980
    In:  Journal of the Royal Society of Medicine Vol. 73, No. 9 ( 1980-09), p. 617-623
    Details
    In: Journal of the Royal Society of Medicine, SAGE Publications, Vol. 73, No. 9 ( 1980-09), p. 617-623
    Abstract: Of 312 patients presenting with breast cancer to a single clinic, 297 were screened for metastases in skin and nodes, bone, marrow, liver and lungs, using standard clinical, radiological scanning and cytological techniques. Thirty-four patients were found to have overt metastatic disease using these tests. Metastases were demonstrable on chest X-ray in 6.1% of the entire group of patients, on the bone scan in 4.2%, liver scan in 1.5%, liver ultrasound in 1.2% and in the bone marrow in only a single patient; 3.8% had contralateral or supraclavicular lymph node metastases or skin metastases. Twenty-eight of these 34 patients (82%) with overt metastases would have been classed as metastatic had only chest X-ray and clinical examination been carried out. A survey was then carried out to determine when tests for bone and liver metastases became abnormal. Bone scan and skeletal survey results were reviewed in 58 patients, 22 of whom had developed skeletal metastases and all of whom had regular skeletal scintigraphy carried out. Sixteen of 20 (80%) scans carried out within six months of the development of skeletal deposits were abnormal compared with 4 of 19 (21%) scans at the same follow-up time in those who failed to develop metastases, but few patients showed definite evidence of bone metastases on scanning prior to radiological metastases. Fifty-one patients who were found to have liver metastases at post-mortem were reviewed and most showed progressively rising alkaline phosphatase before death but only 11 of 57 (19.2%) and 14 of 50 (28%) had positive liver scintiscans and liver ultrasound examinations respectively from 3–12 months before death.
    Type of Medium: Online Resource
    ISSN: 0141-0768 , 1758-1095
    URL: Article
    DOI: 10.1177/014107688007300904
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1980
    detail.hit.zdb_id: 2046643-2
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  • 9
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    Parameters affecting the low-force frictional characteristics of fabrics in automated handling systems
    SAGE Publications ; 2002
    In:  Transactions of the Institute of Measurement and Control Vol. 24, No. 1 ( 2002-03), p. 15-31
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 24, No. 1 ( 2002-03), p. 15-31
    Abstract: Much research has been carried out on the automation of garment assembly but, in practice, many of the techniques suffer from unreliability. In order to investigate why this is so, it is necessary to determine the critical mechanical properties on the fabrics under the conditions that will be found in the handling equipment. This paper concentrates on the frictional properties of fabrics against engineering materials with particular emphasis on these properties under zero applied normal loads, i.e., self-weight. Several tests are described and the main results given. These highlight the importance of humidity and the strong in‘uence of the fabric structure and the supporting surface on the frictional characteristics. It is concluded that either the assembly must be carried out using well defined fabrics and a degree of climate control or that these effects must be carefully considered in the design of handling systems.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1191/0142331202tm044oa
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2025882-3
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  • 10
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    Deoxyglucose Lumped Constant Estimated in a Transplanted Rat Astrocytic Glioma by the Hexose Utilization Index
    SAGE Publications ; 1990
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 10, No. 2 ( 1990-03), p. 190-198
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 10, No. 2 ( 1990-03), p. 190-198
    Abstract: The lumped constant (LC) for calculating the regional glucose (glc) metabolic rate by the deoxyglucose (DG) method was estimated in a transplanted rat glioma and normal rat brain. First, the hexose utilization index (HUI) was measured at 1.5, 3.0, and 4.5 min in right hemisphere glioma implants and uninvolved contralateral hemisphere following bolus intravenous injections of [ 3 H]DG and [ 14 C]glucose. At these times, the glioma HUI values were 0.639, 0.732, and 0.712, respectively, and the coordinate left hemisphere values were 0.432, 0.449, and 0.418. Second, the volumes of distribution of DG and glucose were determined to be 0.436 and 0.235 in glioma implants and 0.402 and 0.237 in left hemisphere, respectively. Third, following simultaneous intracarotid injections of [ 3 H]DG and [ 14 C]glucose, the ratio K* 1 / K 1 was 1.1 in glioma grafts and 1.3 in left hemisphere. With these values for HUI, volume of distribution, and K 1 ratio, the LC in this rat glioma was estimated to be 2.1 times higher than the left hemisphere LC ( p 〈 0.02). These results suggest that measurement of brain tumor CMR glc using a normal brain LC may significantly overestimate the true tumor CMR glc .
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/jcbfm.1990.34
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1990
    detail.hit.zdb_id: 2039456-1
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