In:
American Journal of Nephrology, S. Karger AG
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Nondiabetic individuals aged 30–70 years without a history of cancer were enrolled from the Taiwan Biobank. A total of 6,768 subjects were subjected to a spot urine examination. After quality control using PLINK and imputation using SHAPEIT and IMPUTE2, a total of 3,638,350 single-nucleotide polymorphisms (SNPs) remained for testing. SNPs with a minor allele frequency of less than 0.1% were excluded. Linear regression was used to determine the relationship between SNPs and log urine albumin-to-creatinine ratio. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Six suggestive loci are identified in or near the 〈 i 〉 FCRL3 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.56 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 TMEM161 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 4.43 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 EFCAB1 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.03 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 ELMOD1 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.97 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 RYR3 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 1.34 × 10 〈 sup 〉 −6 〈 /sup 〉 ), and 〈 i 〉 PIEZO2 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.19 × 10 〈 sup 〉 −7 〈 /sup 〉 ). Genetic variants in the 〈 i 〉 FCRL3 〈 /i 〉 gene that encode a secretory IgA receptor are found to be associated with IgA nephropathy, which can manifest as proteinuria. The 〈 i 〉 PIEZO2 〈 /i 〉 gene encodes a sensor for mechanical forces in mesangial cells and renin-producing cells. Five SNPs with a 〈 i 〉 p 〈 /i 〉 -value between 5 × 10 〈 sup 〉 −6 〈 /sup 〉 and 5 × 10 〈 sup 〉 −5 〈 /sup 〉 are also identified in five genes that may have a biological role in the development of albuminuria. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Five new loci and one known suggestive locus for albuminuria are identified in the nondiabetic Taiwanese population.
Type of Medium:
Online Resource
ISSN:
0250-8095
,
1421-9670
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
1468523-1
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