In:
PLOS Computational Biology, Public Library of Science (PLoS), Vol. 18, No. 8 ( 2022-8-29), p. e1010443-
Abstract:
In this paper, a logical-based mathematical model of the cellular pathways involved in the COVID-19 infection has been developed to study various drug treatments (single or in combination), in different illness scenarios, providing insights into their mechanisms of action. Drug simulations suggest that the effects of single drugs are limited, or depending on the scenario counterproductive, whereas better results appear combining different treatments. Specifically, the combination of the anti-inflammatory Baricitinib and the anti-viral Remdesivir showed significant benefits while a stronger efficacy emerged from the triple combination of Baricitinib, Remdesivir, and the corticosteroid Dexamethasone. Together with a sensitivity analysis, we performed an analysis of the mechanisms of the drugs to reveal their impact on molecular pathways.
Type of Medium:
Online Resource
ISSN:
1553-7358
DOI:
10.1371/journal.pcbi.1010443
DOI:
10.1371/journal.pcbi.1010443.g001
DOI:
10.1371/journal.pcbi.1010443.g002
DOI:
10.1371/journal.pcbi.1010443.g003
DOI:
10.1371/journal.pcbi.1010443.g004
DOI:
10.1371/journal.pcbi.1010443.g005
DOI:
10.1371/journal.pcbi.1010443.g006
DOI:
10.1371/journal.pcbi.1010443.t001
DOI:
10.1371/journal.pcbi.1010443.t002
DOI:
10.1371/journal.pcbi.1010443.s001
DOI:
10.1371/journal.pcbi.1010443.s002
DOI:
10.1371/journal.pcbi.1010443.s003
DOI:
10.1371/journal.pcbi.1010443.s004
DOI:
10.1371/journal.pcbi.1010443.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2193340-6
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