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  • Oxford University Press (OUP)  (4)
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  • Oxford University Press (OUP)  (4)
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  • 1
    Online Resource
    Online Resource
    Freeze-dried liposomes as potential carriers for ocular administration of cytochrome 〈I〉c〈/I〉 against selenite cataract formation
    Oxford University Press (OUP) ; 2009
    In:  Journal of Pharmacy and Pharmacology Vol. 61, No. 9 ( 2009-09-01), p. 1171-1178
    Details
    In: Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 61, No. 9 ( 2009-09-01), p. 1171-1178
    Type of Medium: Online Resource
    ISSN: 0022-3573
    URL: Article
    DOI: 10.1211/jpp/61.09.0006
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2009
    detail.hit.zdb_id: 2041988-0
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Freeze-dried liposomes as potential carriers for ocular administration of cytochrome c against selenite cataract formation
    Oxford University Press (OUP) ; 2010
    In:  Journal of Pharmacy and Pharmacology Vol. 61, No. 9 ( 2010-01-08), p. 1171-1178
    Details
    In: Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 61, No. 9 ( 2010-01-08), p. 1171-1178
    Abstract: In this study, the preparation, stability and anti-cataract effect of cationic freeze-dried liposomes containing cytochrome c, along with nicotinamide and adenosine, are described. Methods Cytochrome c-loaded cationic liposomes (CC-L) were prepared by the thin-layer evaporation technique and lyophilized to obtain freeze-dried cytochrome c liposomes (CC-F). The influence of the preparation components on the liposomal encapsulation efficiency and the stability were studied. The anti-cataract effect of the CC-F was demonstrated through attenuating lens opacity development with slit lamp examination in rats with selenite-induced cataract. Key findings Our study indicates that: (1) the liposomal encapsulation efficiency increased with increasing phosphatidylcholine content and reduced in the presence of stearylamine. Moreover, optimal encapsulation efficiency was obtained at an appropriate ratio of phosphatidylcholine to cholesterol; (2) CC-F was stable for at least 12 months at 4°C; (3) satisfactory improvements in lens opacity were shown in the cytochrome c-treated groups, especially for the CC-F-treated group with the decreased percentage of lens opacity at about 28% at the final examination. Conclusions CC-F were shown to be stable superior ophthalmic carriers and were able to markedly retard the onset of cataract development.
    Type of Medium: Online Resource
    ISSN: 0022-3573 , 2042-7158
    URL: Article
    DOI: 10.1211/jpp.61.09.0006
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2010
    detail.hit.zdb_id: 2041988-0
    detail.hit.zdb_id: 2050532-2
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    An investigation on the correlation between drug dissolution properties and the growth behaviour of granules in high shear mixer
    Oxford University Press (OUP) ; 2011
    In:  Journal of Pharmacy and Pharmacology Vol. 63, No. 12 ( 2011-11-08), p. 1548-1558
    Details
    In: Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 63, No. 12 ( 2011-11-08), p. 1548-1558
    Abstract: The aim of this study was to investigate the correlation between the growth behaviour and in-vitro dissolution rate of water-insoluble drugs prepared with high-shear wet granulation. Methods Granules containing nimodipine, microcrystalline cellulose, low-substituted hydroxypropylcellulose and aqueous solution of hydroxypropylcellulose were prepared and the effects of independent process variables, including impeller speed and liquid-to-solid ratio were taken into consideration. The mean granule size, granule-size distribution (GSD), porosity and surface properties were monitored at different kneading times to identify the granule-growth mechanisms simultaneously. A computer-based method was applied to simulate the dissolution behaviour of polydisperse granules based on the GSD data. Key findings The in-vitro dissolution rate of drug was high for the early stages of granulation and sharply decreased when coalescence and consolidation of granules started, approaching a flat and low level when granules were sufficiently consolidated. The simulated dissolution results were in agreement with experimental observations and were significantly affected by the GSD, porosity and surface properties of granules during the granulation process. Moreover the GSD was directly related to the granule-growth behaviour and mechanisms. Conclusions In general, it was concluded that the dissolution properties of nimodipine basically correlated with the growth behaviour of granules in a high-shear mixer. The simulation method based on GSD can be used as a convenient and rapid way to predict the dissolution properties for formulation development and granulation optimization.
    Type of Medium: Online Resource
    ISSN: 0022-3573 , 2042-7158
    URL: Article
    DOI: 10.1111/j.2042-7158.2011.01362.x
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
    detail.hit.zdb_id: 2041988-0
    detail.hit.zdb_id: 2050532-2
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    An ocular drug delivery system containing zinc diethyldithiocarbamate and HPβCD inclusion complex - corneal permeability, anti-cataract effects and mechanism studies
    Oxford University Press (OUP) ; 2010
    In:  Journal of Pharmacy and Pharmacology Vol. 56, No. 10 ( 2010-02-18), p. 1251-1257
    Details
    In: Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 56, No. 10 ( 2010-02-18), p. 1251-1257
    Abstract: Our purpose was to study the formulation and anti-cataract effects of aqueous eye drops containing a high concentration of zinc diethyldithiocarbamate (Zn-DDC). A possible mechanism of the anti-cataract effect of Zn-DDC was also studied. Zn-DDC and hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complex (Zn-DDC/HPβCD) was studied using the saturation solution method and characterized by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (IR). Suitable formulations for Zn-DDC eye drops were established by means of in-vitro trans-corneal penetration experiments. The anti-cataract effect of the selected formulation was demonstrated by the delay in lens opacity development in hereditary shumuya cataract rats (SCRs). Semiquantitative reverse transcription polymerase chain reaction (RT-PCR) was performed to study the effect of diethyldithiocarbamate (DDC), a metabolite of Zn-DDC, on the transcription inducible nitric oxide synthase (iNOS) mRNA in human lens epithelial cells (HLEC). In the presence of 22% (w/v) HPβCD, the solubility of Zn-DDC in water (0.2 mm) was increased almost 850 fold (to 17 mm), by the formation of Zn-DDC/HPβCD. The stoichiometry of Zn-DDC inclusion was 1:1. The Zn-DDC/HPβCD stability constant, K(s) (1:1) was estimated to be 3453 m−1. The ophthalmic preparation containing 0.1% HPMC and 0.1% poloxamer 188 (P188) exhibited better permeability than the others in-vitro, and significantly delayed cataract formation in SCRs compared with non-treated SCRs. DDC inhibits the transcription of iNOS mRNA in HLEC. We concluded that this drug delivery system increases both the drug solubility in aqueous eye drops and the permeability of drug through the rabbit cornea, by the formation of a drug-cyclodextrin inclusion complex and the addition of polymers and penetration enhancers. The preparation effectively prevented the development of cataracts in SCRs. DDC, the metabolite of Zn-DDC, may be one of the factors in the prevention of cataract formation because it inhibits the transcription of iNOS mRNA.
    Type of Medium: Online Resource
    ISSN: 0022-3573 , 2042-7158
    URL: Article
    DOI: 10.1211/0022357044526
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2010
    detail.hit.zdb_id: 2041988-0
    detail.hit.zdb_id: 2050532-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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