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  • 1
    Publication Date: 2012-07-10
    Description: We present a comprehensive convergence analysis for discontinuous piecewise polynomial approximations of a first-kind Volterra integral equation with smooth convolution kernel, examining the attainable order of (super-) convergence in collocation, quadrature discontinuous Galerkin (QDG) and full discontinuous Galerkin (DG) methods. We introduce new polynomial basis functions with properties that greatly simplify the convergence analysis for collocation methods. This also enables us to determine explicit formulae for the location of superconvergence points (i.e., discrete points at which the convergence order is one higher than the global bound) for all convergent collocation schemes. We show that a QDG method, which is based on piecewise polynomials of degree m and uses exactly m + 1 quadrature points and nonzero quadrature weights, is equivalent to a collocation scheme, and so its convergence properties are fully determined by the previous collocation analysis and they depend only on the quadrature point location (in particular, they are completely independent of the accuracy of the quadrature rule). We also give a complete analysis for QDG with more than m + 1 quadrature points when the degree of precision (d.o.p.) is at least 2 m + 1. The behaviour (but not the approximation) is the same as that for a DG scheme when the d.o.p. is at least 2 m + 2. Numerical test results confirm that the theoretical convergence rates are optimal.
    Print ISSN: 0272-4979
    Electronic ISSN: 1464-3642
    Topics: Mathematics
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  • 2
    Publication Date: 2014-08-09
    Description: We present completed observations of the NGC 7448 galaxy group and background volume as part of the blind neutral hydrogen Arecibo Galaxy Environment Survey. Our observations cover a region spanning 5° x 4°, over a redshift range of approximately –2000 〈 cz  〈 20 000 km s –1 . A total of 334 objects are detected, mostly in three overdensities at cz  ~ 7500, cz  ~ 9600 and cz  ~ 11 400 km s –1 . The galaxy density is extremely high (15 deg –2 ) and many (~24 per cent) show signs of extended H  i emission, including some features as much as 800 kpc in projected length. We describe the overall characteristics of this environment: kinematics, typical galaxy colours and mass-to-light ratios, and substructure. To aid in the cataloguing of this data set, we present a new fits viewer ( frelled : fits Realtime Explorer of Low Latency in Every Dimension). This incorporates interactive source cataloguing tools which increase our source extraction speed by approximately a factor of 50.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 3
    Publication Date: 2016-09-20
    Description: We report the discovery of 14 Lyα blobs (LABs) at z  ~ 0.3, existing at least 4–7 billion years later in the Universe than all other LABs known. Their optical diameters are 20–70 kpc, and GALEX data imply Lyα luminosities of (0.4–6.3)  x  10 43  erg s –1 . Contrary to high- z LABs, they live in low-density areas. They are ionized by AGN, suggesting that cold accretion streams as a power source must deplete between z  = 2 and 0.3. We also show that transient AGN naturally explain the ionization deficits observed in many LABs. Their Lyα and X-ray fluxes decorrelate below 10 6 years because of the delayed escape of resonantly scattering Lyα photons. High Lyα luminosities do not require currently powerful AGN, independent of obscuration. Chandra X-ray data reveal intrinsically weak AGN, confirming the luminous optical nebulae as impressive ionization echoes . For the first time, we also report mid-infrared thermal echoes from the dusty tori. We conclude that the AGN have faded by three to four orders of magnitude within the last 10 4–5 years, leaving fossil UV, optical and thermal radiation behind. The host galaxies belong to the group of previously discovered Green Bean galaxies (GBs). Gemini optical imaging reveals smooth spheres, mergers, spectacular outflows and ionization cones. Because of their proximity and high flux densities, GBs are perfect targets to study AGN feedback, mode switching and the Lyα escape. The fully calibrated, co-added optical FITS images are publicly available.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 4
    Publication Date: 2012-10-30
    Description: Aims To establish the prevalence of atrial fibrillation (AF) in the general population in the UK, and in those with risk factors. Methods and results The prevalence of AF on electrocardiography was established in prospectively selected groups: 3960 randomly selected from the population, aged 45+; 782 with a previous diagnosis of heart failure; and 1062 with a record of myocardial infarction, hypertension, angina, or diabetes. Patients were also assessed clinically and with echocardiography. Mortality was tracked for 8 years. Atrial fibrillation was found in 78 of the random population sample (2.0%). Prevalence was 1.6% in women and 2.4% in men, rising with age from 0.2% in those aged 45–54 to 8.0% in those aged 75 and older. Half of all cases were in patients aged 75 and older. Only 23 of the 78 (29.5%) of those in AF took warfarin. Of the 782 patients, 175 (22.4%) with a diagnosis of heart failure were in AF, with normal left ventricular function in 95 (54.3%) of these. Atrial fibrillation was found in 14 of the 244 (5.7%) of those with a history of myocardial infarction, 15 of the 388 (3.9%) of those with hypertension, 15 of the 321 (4.7%) of those with angina, and 11 of the 208 (5.3%) of diabetics. Adjusting for age and sex, mortality was 1.57 times higher for those in AF. Conclusion Atrial fibrillation is common in the elderly and those with clinical risk factors. Screening these groups would identify many with AF. Use of anticoagulation was low at the time of the initial assessments in the late 1990s; practice may have changed recently.
    Print ISSN: 1099-5129
    Electronic ISSN: 1532-2092
    Topics: Medicine
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  • 5
    Publication Date: 2015-03-25
    Description: Background.  Persons with blood-stage Plasmodium falciparum parasitemia in the absence of symptoms are considered to be clinically immune. We hypothesized that asymptomatic subjects with P. falciparum parasitemia would differentially recognize a subset of P. falciparum proteins on a genomic scale. Methods and Findings.  Compared with symptomatic subjects, sera from clinically immune, asymptomatically infected individuals differentially recognized 51 P. falciparum proteins, including the established vaccine candidate PfMSP1. Novel, hitherto unstudied hypothetical proteins and other proteins not previously recognized as potential vaccine candidates were also differentially recognized. Genes encoding the proteins differentially recognized by the Peruvian clinically immune individuals exhibited a significant enrichment of nonsynonymous nucleotide variation, an observation consistent with these genes undergoing immune selection. Conclusions.  A limited set of P. falciparum protein antigens was associated with the development of naturally acquired clinical immunity in the low-transmission setting of the Peruvian Amazon. These results imply that, even in a low-transmission setting, an asexual blood-stage vaccine designed to reduce clinical malaria symptoms will likely need to contain large numbers of often-polymorphic proteins, a finding at odds with many current efforts in the design of vaccines against asexual blood-stage P. falciparum .
    Print ISSN: 0022-1899
    Electronic ISSN: 1537-6613
    Topics: Medicine
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  • 6
    Publication Date: 2012-05-01
    Description: In metropolitan areas, road traffic is a major contributor to ambient air pollution and the dominant source of community noise. The authors investigated the independent and joint influences of community noise and traffic-related air pollution on risk of coronary heart disease (CHD) mortality in a population-based cohort study with a 5-year exposure period (January 1994–December 1998) and a 4-year follow-up period (January 1999–December 2002). Individuals who were 45–85 years of age and resided in metropolitan Vancouver, Canada, during the exposure period and did not have known CHD at baseline were included ( n = 445,868). Individual exposures to community noise and traffic-related air pollutants, including black carbon, particulate matter less than or equal to 2.5 μm in aerodynamic diameter, nitrogen dioxide, and nitric oxide, were estimated at each person’s residence using a noise prediction model and land-use regression models, respectively. CHD deaths were identified from the provincial death registration database. After adjustment for potential confounders, including traffic-related air pollutants or noise, elevations in noise and black carbon equal to the interquartile ranges were associated with 6% (95% confidence interval: 1, 11) and 4% (95% confidence interval: 1, 8) increases, respectively, in CHD mortality. Subjects in the highest noise decile had a 22% (95% confidence interval: 4, 43) increase in CHD mortality compared with persons in the lowest decile. These findings suggest that there are independent effects of traffic-related noise and air pollution on CHD mortality.
    Print ISSN: 0002-9262
    Electronic ISSN: 1476-6256
    Topics: Medicine
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  • 7
    Publication Date: 2012-09-15
    Description: Aims Biochemical marker testing has improved the evaluation and management of patients with cardiovascular diseases over the past decade. Natriuretic peptides (NPs), used in clinical practice to assess cardiac dysfunction, exhibit many limitations, however. We used an unbiased proteomics approach for the discovery of novel diagnostic plasma biomarkers of heart failure (HF). Methods and results A proteomics pipeline adapted for very low-abundant plasma proteins was applied to clinical samples from patients admitted with acute decompensated HF (ADHF). Quiescin Q6 (QSOX1), a protein involved in the formation of disulfide bridges, emerged as the best performing marker for ADHF (with an area under the receiver operator characteristic curve of 0.86, 95% confidence interval: 0.79–0.92), and novel isoforms of NPs were also identified. Diagnostic performance of QSOX1 for ADHF was confirmed in 267 prospectively collected subjects of whom 76 had ADHF. Combining QSOX1 to B-type NP (BNP) significantly improved diagnostic accuracy for ADHF by particularly improving specificity. Using thoracic aortic constriction in rats, QSOX1 was specifically induced within both left atria and ventricles at the time of HF onset. Conclusion The novel biomarker QSOX1 accurately identifies ADHF, particularly when combined with BNP. Through both clinical and experimental studies we provide lines of evidence for a link between ADHF and cardiovascular production of QSOX1.
    Print ISSN: 0195-668X
    Electronic ISSN: 1522-9645
    Topics: Medicine
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  • 8
    Publication Date: 2018-03-06
    Description: Science diplomacy is lauded as a catalyst for cooperation in international spaces. International science cooperation is a duty under international law and a necessity in reality. With the international community poised to begin historic negotiations to develop a new international legally binding instrument for the conservation and sustainable use of biodiversity in areas beyond national jurisdiction, it is timely to consider what role science diplomacy could play in advancing governance of this vast international space encompassing 64% of the ocean’s surface. In this article, three forms of science diplomacy are examined: how international science collaboration could provide a unifying focus in the development of the new instrument (science for diplomacy), what opportunities and challenges this could pose for global ocean science (diplomacy for science), and how scientists, as stakeholders, could help to identify and overcome obstacles (science in diplomacy). Learning from past examples of science diplomacy in international spaces and engaging a diverse group of scientific stakeholders to look to the future would enable ocean science to be a unifying focus for this new agreement.
    Print ISSN: 1054-3139
    Electronic ISSN: 1095-9289
    Topics: Biology , Geosciences , Physics
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