Description: The thermal conductivity of monolayer graphene nanoribbons (GNRs) with different tensile strain is investigated by using a nonequilibrium molecular dynamics method. Significant increasing amplitude of the molecular thermal vibration, molecular potential energy vibration and thermal conductivity vibration of stretching GNRs were detected. Some 20%~30% thermal conductivity decay is found in 9%~15% tensile strain of GNR cases. It is explained by the fact that GNR structural ridges scatter some low-frequency phonons which pass in the direction perpendicular to the direction of GNR stretching which was indicated by a phonon density of state investigation.

Description: Air conditioners have great potential to participate in power system frequency control. This paper proposes a control strategy to facilitate the active participation of air conditioners. For each air conditioner, a decentralized control law is designed to adjust its temperature set point in response to the system frequency deviation. The decentralized control law accounts for the user’s thermal comfort that is evaluated by a fuzzy algorithm. The aggregation of air conditioners’ response is conducted by using the Monte Carlo simulation method. A structure preserving model is applied to the multi-bus power system, in which air conditioners are aggregated at certain load buses. An inner-outer iteration scheme is adopted to solve power system dynamics. An experiment is conducted on a test air conditioner to examine the performance of the proposed decentralized control law. Simulation results on a test power system verify the effectiveness of the proposed strategy for air conditioners participating in frequency control.

Description: IJERPH, Vol. 14, Pages 1284: Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat International Journal of Environmental Research and Public Health doi: 10.3390/ijerph14101284 Authors: Tan Ma Xiaoqin Yin Ruitong Han Jie Ding Huan Zhang Xiaodong Han Dongmei Li Humans are inevitably exposed to ubiquitous phthalate esters (PAEs). In utero exposure to di-n-butyl phthalate (DBP) induces abnormal development of the testis and reproductive tract in male offspring, which correspond closely with the human condition of testicular dysgenesis syndrome (TDS)-like syndrome. However, the underlying mechanisms have not been elucidated in detail. In this study, pregnant rats were orally exposed to either corn oil (controls) or DBP at three different doses by gavage during Gestational Days 12.5–21.5. Pathological examinations were performed for toxicity evaluation. Proliferation and apoptosis related proteins (ras related dexamethasone induced 1 (Rasd1), mitogen-activated protein kinase kinases1/2 (MEK1/2), Bcl-2, and Bax) were measured for mechanisms exploration. The results showed that different doses of DBP caused male developmental and reproductive toxicity in rats, including the decrease of anogenital distance (AGD), the histological damage of testis, and apoptosis of seminiferous tubule cells. Our data suggested that DBP played chronic and continuous toxic roles on male reproductive system by disrupting expression of Rasd1 and MEK1/2 as well as Bcl-2/Bax ratio. Further research is warranted.

Description: Sensors, Vol. 18, Pages 1163: A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging Sensors doi: 10.3390/s18041163 Authors: Yanling Hu Donlgliang Yang Chen Yang Ning Feng Zhouwei Shao Lei Zhang Xiaodong Wang Lixing Weng Zhimin Luo Lianhui Wang A novel fluorescent “off-on” probe based on carbon nitride (C3N4) nanoribbons was developed for citrate anion (C6H5O73−) detection. The fluorescence of C3N4 nanoribbons can be quenched by Cu2+ and then recovered by the addition of C6H5O73−, because the chelation between C6H5O73− and Cu2+ blocks the electron transfer between Cu2+ and C3N4 nanoribbons. The turn-on fluorescent sensor using this fluorescent “off-on” probe can detect C6H5O73− rapidly and selectively, showing a wide detection linear range (1~400 μM) and a low detection limit (0.78 μM) in aqueous solutions. Importantly, this C3N4 nanoribbon-based “off-on” probe exhibits good biocompatibility and can be used as fluorescent visualizer for exogenous C6H5O73− in HeLa cells.

Description: Sensors, Vol. 18, Pages 1595: Visual and Colorimetric Sensing of Metsulfuron-Methyl by Exploiting Hydrogen Bond-Induced Anti-Aggregation of Gold Nanoparticles in the Presence of Melamine Sensors doi: 10.3390/s18051595 Authors: Guangyang Liu Ruonan Zhang Xiaodong Huang Lingyun Li Naixin Liu Jing Wang Donghui Xu Various highly sensitive and selective analytical methods have been used to monitor metsulfuron-methyl residue in the environment. However, these methods involve costly instruments and complex, time-consuming operations performed in laboratories. Here, a rapid, convenient, and sensitive colorimetric sensor based on anti-aggregation of gold nanoparticles (AuNPs) is demonstrated for the rapid detection of metsulfuron-methyl in agricultural irrigation water. The AuNPs could be induced to aggregate in the presence of melamine and exhibited a distinct color change from wine-red to blue. The aggregation was suppressed by a strong hydrogen-bonding interaction between metsulfuron-methyl and melamine. The differences of the absorbance at 523 nm (ΔA523) and the color change was linearly related to metsulfuron-methyl concentration over the range 0.1–100 mg/L, as observed visually and by UV-vis (Ultraviolet-visible) spectrometry. The detection limit of the sensor was as low as 0.05 mg/L (signal/noise = 3), and was used to determine metsulfuron-methyl in spiked water and in agricultural irrigation water samples. Recoveries were in the range of 71.2–100.4%, suggesting that the colorimetric sensor was suitable for the determination of metsulfuron-methyl in agricultural water samples.

Description: Energies, Vol. 10, Pages 1602: Rate Decline Analysis of Vertically Fractured Wells in Shale Gas Reservoirs Energies doi: 10.3390/en10101602 Authors: Xiaoyang Zhang Xiaodong Wang Xiaochun Hou Wenli Xu Based on the porous flow theory, an extension of the pseudo-functions approach for the solution of non-linear partial differential equations considering adsorption-desorption effects was used to investigate the transient flow behavior of fractured wells in shale gas reservoirs. The pseudo-time factor was employed to effectively linearize the partial differential equations of the unsteady flow response. The production performance of vertically fractured wells in shale gas reservoirs under either constant flow rate or constant bottom-hole pressure conditions was analyzed using the composite flow model. The calculation results indicate that the non-linearities that develop in the gas diffusivity equation have significant effects on the unsteady response, leading to a larger pressure depletion and rate decline in the late-time period. In addition, gas desorption from the shale acts as a recharge source, which relieves the gas production rate of decline. Greater values for the Langmuir volumes or Langmuir pressures provide additional pressure support, leading to a lower rate decline while the flowing well bottom-hole pressure is maintained. The reservoir size mainly affects the duration of the pressure depletion and rate decline. In the case of ignoring the non-linearity and adsorption-desorption effect in the differential equation, a greater rate decline under constant bottom-hole pressure production can be obtained during the boundary-dominated depletion. This work provides a better understanding of gas desorption in shale gas reservoirs and new insight into investigating the production performances of fractured gas well.

Description: Detailed analysis of continuous time-series data from regions undergoing rapid urbanization can accurately reveal spatial variations on short time scales. This study used the city of Changchun in Jilin Province, China, as a case study to analyze total and annual changes in area—especially decreases in rural settlement area—as well as regional differences in these changes and driving forces of rural settlement evolution. Quantitative analytical techniques include a dynamic percentage of rural settlements, the distribution index of rural settlements, the regression correlation analysis, and other spatial analysis methods. Data were derived from a variety of sources, including land-use databases and social and economic statistics. The results show that the area of rural settlements decreased between 2009 and 2014, with the urban construction land expansion and decreases in cultivated lands. Rural settlements also became increasingly fragmented after 2009. Most of the rural settlements were located close to the urban construction land, and changes in rural settlement area were more pronounced with decreasing distance to the closest urban construction land, illustrating the effect of urban sprawl on rural settlement changes. The analysis also shows that the decreasing area of rural settlements between 2009 and 2014 is directly caused by urban sprawl. Regional development strategies and urban planning indirectly contribute to changes in the scale and spatial distribution of rural settlements by guiding urban development. The geographical environment and strict cultivated-land-protection policies also indirectly restrict changes in rural settlements by determining the restrictive area of urban expansion. No significant changes were found in the influence of population change on changing areas of rural settlements. In conclusion, the interaction of strategy for social-economic development, natural geography environments, and human demand jointly caused changes in rural settlements.

Description: Histone deacetylase inhibitors (HDACIs), such as vorinostat and panobinostat, have been shown to have active effects on many hematologic malignancies, including multiple myeloma and cutaneous T-cell lymphoma. Hydroxamate-based (Hb) HDACIs have very good toxicity profiles and are currently being tested in phases I and II clinical trials with promising results in selected neoplasms, such as bladder carcinoma. One of the Hb-HDACIs, HZ1006, has been demonstrated to be a promising drug for clinical use. The aim of our study was to determine the possible target of toxicity and to identify a non-toxic dose of HZ1006 for clinical use. In our studies, the repeated dosage toxicity of HZ1006 in Beagle dogs and Sprague Dawley (SD) rats was identified. Dogs and rats received HZ1006 orally (0–80 and 0–120 mg/kg/day, respectively) on a continuous daily dosing agenda for 28 days following a 14-day dosage-free period. HZ1006’s NOAEL (No Observed Adverse Effect Level) by daily oral administration for dogs and rats was 5 mg/kg and 60 mg/kg, respectively, and the minimum toxic dose was 20 and 120 mg/kg, respectively. All the side effects indicated that the digestive tract, the male reproductive tract, the respiratory tract and the hematological systems might be HZ1006 toxic targets in humans. HZ1006 could be a good candidate or a safe succedaneum to other existing HDACIs for the treatment of some solid tumor and hematologic malignancies.

Description: The Scalar Triangulation and Ranging (STAR) method, which is based upon the unique properties of magnetic gradient contraction, is a high real-time ferromagnetic target localization method. Only one measurement point is required in the STAR method and it is not sensitive to changes in sensing platform orientation. However, the localization accuracy of the method is limited by the asphericity errors and the inaccurate value of position leads to larger errors in the estimation of magnetic moment. To improve the localization accuracy, a modified STAR method is proposed. In the proposed method, the asphericity errors of the traditional STAR method are compensated with an iterative algorithm. The proposed method has a fast convergence rate which meets the requirement of high real-time localization. Simulations and field experiments have been done to evaluate the performance of the proposed method. The results indicate that target parameters estimated by the modified STAR method are more accurate than the traditional STAR method.

Description: Energies, Vol. 11, Pages 1637: A Coordinated DC Power Support Strategy for Multi-Infeed HVDC Systems Energies doi: 10.3390/en11071637 Authors: Chunlei Zhang Xiaodong Chu Bing Zhang Linlin Ma Xin Li Xiaobo Wang Liang Wang Cheng Wu A DC power support strategy utilizes the flexibility of a High-voltage direct-current (HVDC) system in power modulation to optimize the operating point or compensate the power imbalance caused by a disturbance. The major impediment to the strategy is the difficulty in maintaining DC voltage values at converter stations during the process of DC power support. To overcome the difficulty, a coordinated DC power support strategy for multi-infeed HVDC systems is proposed in this paper. Synchronous condensers are employed to provide dynamic reactive power compensation in sustaining DC voltage values at converter stations. Models are built for the optimal leading phase operation and adjusting excitation voltage reference value of synchronous condensers. Multiple HVDC links are coordinated to participate by using the DC power support factor to rank and select the links. Optimal DC power support values of the participating HVDC links are obtained with a comprehensive stability margin index that accounts for transient stability of the sending-end systems and frequency security of the receiving-end systems. An optimal load shedding model is used to ensure the frequency security of receiving-end systems. Case study results of a provincial power system in China demonstrate the effectiveness and performance of the proposed DC power support strategy.