In:
Molecular and Cellular Biology, Informa UK Limited, Vol. 14, No. 1 ( 1994-01), p. 207-213
Abstract:
Translation of thymidylate synthase (TS) mRNA is controlled by its own protein product, TS, in an autoregulatory manner. Direct binding of TS protein to two different cis-acting elements on the TS mRNA is associated with this translational regulation. In this study, an immunoprecipitation-reverse transcription-PCR technique was used to identify a TS ribonucleoprotein (RNP) complex in cultured human colon cancer cells. Using antibodies specific for TS protein, we show that TS is complexed in vivo with its own TS RNA. Furthermore, evidence demonstrating a direct interaction between the mRNA of the nuclear oncogene c-myc and TS protein is presented.
Type of Medium:
Online Resource
ISSN:
0270-7306
,
1098-5549
DOI:
10.1128/MCB.14.1.207
Language:
English
Publisher:
Informa UK Limited
Publication Date:
1994
detail.hit.zdb_id:
1474919-1
SSG:
12
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