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  • Hindawi Limited  (22)
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  • Hindawi Limited  (22)
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  • 1
    Online Resource
    Online Resource
    Design and Realize a Snake-Like Robot in Complex Environment
    Hindawi Limited ; 2019
    In:  Journal of Robotics Vol. 2019 ( 2019-02-03), p. 1-9
    Details
    In: Journal of Robotics, Hindawi Limited, Vol. 2019 ( 2019-02-03), p. 1-9
    Abstract: Aiming at high performance requirements of snake-like robots under complex environment, we present a control system of our proposed design which utilizes a STM32 as the core processor and incorporates real-time image acquisition, multisensor fusion, and wireless communication technology. We use Solidworks to optimize the design of head, body, and tail joint structure of the snake-like robot. The system is a real-time system with a simple-circuit structure and multidegrees of freedom are attributed to the flawless design of control system and mechanical structure. We propose a control method based on our simplified CPG model. Meanwhile, we improve Serpenoid control function and then investigate how different parameters affect the motion gait in terms of ADAMS emulation. Finally, experimental results show that the snake-like robot can tackle challenging problems including multi-information acquisition and processing, multigait stability, and autonomous motion and further verify the reliability and accuracy of the system in our combinatory experiments.
    Type of Medium: Online Resource
    ISSN: 1687-9600 , 1687-9619
    URL: Article
    DOI: 10.1155/2019/1523493
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2582988-9
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  • 2
    Online Resource
    Online Resource
    FLT3 Amplification as Double Minute Chromosomes in a Patient with Chronic Myelomonocytic Leukemia
    Hindawi Limited ; 2021
    In:  Disease Markers Vol. 2021 ( 2021-6-5), p. 1-6
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2021 ( 2021-6-5), p. 1-6
    Abstract: Double minute chromosomes (dmins) are a form of gene amplification presenting as small spherical paired chromatin bodies. Dmins are rare in hematologic malignancies and are generally associated with a poor prognosis. Some case reports identified MYC or MLL gene amplification performing as dmin in myeloid neoplasms. FLT3 (FMS-related tyrosine kinase 3) acts as an oncogene in myeloid neoplasms which is associated with several signal transduction pathways. Genomic amplification of FLT3 has not been reported in hematological disease. The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). Routine G-banded karyotype, array-based comparative genomic hybridization, and fluorescence in situ hybridization analyses were used to characterize the cytogenetic abnormality in the patient’s bone marrow. FLT3 amplification as dmins in a patient with CMML was revealed. This case study reports a rare double minute chromosome via FLT3 amplification in CMML by using array-based comparative genomic hybridization and fluorescence in situ hybridization analyses. The study also proposed another possible mechanism of FLT3 genes in leukemogenesis.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2021/9932837
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2033253-1
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  • 3
    Online Resource
    Online Resource
    High-Resolution Squinted SAR Imaging Algorithm Applied in the Near-Field Environment
    Hindawi Limited ; 2020
    In:  Complexity Vol. 2020 ( 2020-05-22), p. 1-13
    Details
    In: Complexity, Hindawi Limited, Vol. 2020 ( 2020-05-22), p. 1-13
    Abstract: In the squinted synthetic aperture radar (SAR) imaging of the near-field environment, range-dependent characteristic of squint angle cannot be ignored, which causes azimuth-dependent range cell migration (RCM) after linear range walk correction (LRWC). In this study, an efficient SAR imaging algorithm applied in the near-field environment is proposed. In the processing of the range focusing, LRWC is firstly used to remove the linear RCM. Then, the residual LRCM is expanded into azimuth-invariant and azimuth-variant terms in consideration of the residual LRCM of azimuth-dependent. Range cell migration azimuth scaling (RCMAS) is designed to remove the azimuth-variant term before secondary range compression (SRC) and range compression (RC). In the azimuth focusing, azimuth distortion compensation (ADC) is performed to compensate the azimuth distortion, following which azimuth nonlinear chirp scaling (ANCS) is applied to equalize the frequency modulation (FM) rate for azimuth compression (AC). The simulated results show that more accurate and improved imaging result can be obtained with the proposed algorithm.
    Type of Medium: Online Resource
    ISSN: 1076-2787 , 1099-0526
    URL: Article
    DOI: 10.1155/2020/1647957
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Artificial Neural Network-Based Method for Seismic Analysis of Concrete-Filled Steel Tube Arch Bridges
    Hindawi Limited ; 2021
    In:  Computational Intelligence and Neuroscience Vol. 2021 ( 2021-4-5), p. 1-10
    Details
    In: Computational Intelligence and Neuroscience, Hindawi Limited, Vol. 2021 ( 2021-4-5), p. 1-10
    Abstract: Seismic analysis of concrete-filled steel tube (CFST) arch bridge based on finite element method is a time-consuming work. Especially when uncertainty of material and structural parameters are involved, the computational requirements may exceed the computational power of high performance computers. In this paper, a seismic analysis method of CFST arch bridge based on artificial neural network is presented. The ANN is trained by these seismic damage and corresponding sample parameters based on finite element analysis. In order to obtain more efficient training samples, a uniform design method is used to select sample parameters. By comparing the damage probabilities under different seismic intensities, it is found that the damage probabilities of the neural network method and the finite element method are basically the same. The method based on ANN can save a lot of computing time.
    Type of Medium: Online Resource
    ISSN: 1687-5273 , 1687-5265
    URL: Article
    DOI: 10.1155/2021/5581637
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2388208-6
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  • 5
    Online Resource
    Online Resource
    Autologous Bone Marrow Mesenchymal Stem Cells Associated with Tantalum Rod Implantation and Vascularized Iliac Grafting for the Treatment of End-Stage Osteonecrosis of the Femoral Head
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-9
    Abstract: Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients with osteonecrosis of the femoral head (ONFH) to avert the need for total hip arthroplasty (THA). However, there have been unsatisfactory success rates for end-stage ONFH. The authors describe a modified technique using bone marrow mesenchymal stem cells (BMMSCs) associated with porous tantalum rod implantation combined with vascularized iliac grafting for the treatment of end-stage ONFH. A total of 24 patients (31 hips) with end-stage ONFH were treated with surgery; ARCO IIIc stage was observed in 19 hips and ARCO IV stage was observed in 12 hips. All patients were followed for a mean time of 64.35 ± 13.03 months (range 26–78). Operations on only five hips were converted to THA. The joint-preserving success rate of the entire group was 89.47% for ARCO stage IIIc and 75% for ARCO stage IV. The mean Harris hip score of the 31 hips improved significantly from 38.74 ± 5.88 points (range 22–50) to 77.23 ± 14.75 points (range 33–95). This intervention was safe and effective in delaying or avoiding total hip replacement for end-stage ONFH.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/240506
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    MiR-29a Inhibits Glioma Tumorigenesis through a Negative Feedback Loop of TRAF4/Akt Signaling
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018-08-14), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018-08-14), p. 1-8
    Abstract: Background . MiR-29a is known as a repressor of human cancer. However, its relevance in glioma proliferation and invasion remains largely unknown. In this study, we aimed to investigate the function and mechanism of miR-29a in glioma tumorigenesis. Methods . The expression of miR-29a was determined by using qRT-PCR. CCK-8, wound healing, and transwell invasion assays were carried out to analyze the effects of miR-29a in glioblastoma cells. qRT-PCR, luciferase reporter, and western blot experiments were done to validate the targeting of TRAF4/Akt pathway by miR-29a. The expression correlation between levels of TRAF4 and miR-29a was analyzed. Regulation of miR-29a expression by enhanced/reduced TRAF4/Akt expression was finally confirmed by qRT-PCR. Results . MiR-29a was decreased in the glioma tissues, especially in those at higher grades. Following its mimic transfection, we validated that miR-29a inhibited cell proliferation, migration, and invasion. Consistently, miR-29a inhibition induced the opposite effects on cell proliferation, migration, and invasion. We confirmed TRAF4 as a direct target of miR-29a, which might mediate the Akt pathway activation. We showed a significantly negative expression correlation between TRAF4 and miR-29a in normal and glioma tissues. Finally we observed an upregulation of miR-29a in TRAF4/Akt activated cells. Conclusion . MiR-29a is critical tumor suppressor for glioma tumorigenesis by forming a negative feedback loop of TRAF4/Akt signaling and represents a potent therapeutic candidate for treating gliomas.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/2461363
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes
    Hindawi Limited ; 2013
    In:  BioMed Research International Vol. 2013 ( 2013), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2013 ( 2013), p. 1-11
    Abstract: Hepatocellular carcinoma (HCC) is a highly aggressive and lethal cancer. It is typically asymptomatic at the early stage, with only 10%–20% of HCC patients being diagnosed early enough for appropriate surgical treatment. The delayed diagnosis of HCC is associated with limited treatment options and much lower survival rates. Therefore, the early and accurate detection of HCC is crucial to improve its currently dismal prognosis. The epidermal growth factor receptor (EGFR) has been reported to be involved in HCC tumorigenesis and to represent an attractive target for HCC imaging and therapy. In this study, an affibody molecule, Ac-Cys-Z EGFR:1907 , targeting the extracellular domain of EGFR, was used for the first time to assess its potential to detect HCC xenografts. By evaluating radio- or fluorescent-labeled Ac-Cys-Z EGFR:1907 as a probe for positron emission tomography (PET) or optical imaging of HCC, subcutaneous EGFR-positive HCC xenografts were found to be successfully imaged by the PET probe. Thus, affibody-based PET imaging of EGFR provides a promising approach for detecting HCC in vivo .
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2013/759057
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2698540-8
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  • 8
    Online Resource
    Online Resource
    On the existence of solutions to a fourth-order quasilinear resonant problem
    Hindawi Limited ; 2002
    In:  Abstract and Applied Analysis Vol. 7, No. 3 ( 2002), p. 125-133
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 7, No. 3 ( 2002), p. 125-133
    Abstract: By means of Morse theory we prove the existence of a nontrivial solution to a superlinear p -harmonic elliptic problem with Navier boundary conditions having a linking structure around the origin. Moreover, in case of both resonance near zero and nonresonance at + ∞ the existence of two nontrivial solutions is shown.
    Type of Medium: Online Resource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/S1085337502000805
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2002
    detail.hit.zdb_id: 2064801-7
    SSG: 17,1
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  • 9
    Online Resource
    Online Resource
    A ResNet-LSTM Based Credit Scoring Approach for Imbalanced Data
    Hindawi Limited ; 2022
    In:  Mobile Information Systems Vol. 2022 ( 2022-4-26), p. 1-14
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2022 ( 2022-4-26), p. 1-14
    Abstract: Detecting potential defaults or bad debt with limited information has become a huge challenge. The main difficulties faced by the credit scoring are sample imbalance and poor classification performance. For this reason, we first proposed the auxiliary conditional tabular generative adversarial network (ACTGAN) to generate sufficient default transaction samples from the original data, then we designed a model based on ResNet-LSTM used for feature extraction, which includes two submodels of ResNet and LSTM to extract static local features and dynamic temporal features from the original data, respectively. After that, a spatiotemporal attention module is added to calculate the importance of the two submodel’s output in order to extract more critical information. Finally, we applied the focus loss function into the XGBoost classifier to improve the probability output of the credit default risk. We verified the designed credit scoring model in two real-world datasets. The experimental results showed that ACTGAN can effectively solve the problem of data imbalance. The ResNet-LSTM+XGBoost model for classification is better than other traditional algorithms in F1 value, AUC, and KS value, which proves the effectiveness and portability of this model in the field of credit scoring.
    Type of Medium: Online Resource
    ISSN: 1875-905X , 1574-017X
    URL: Article
    DOI: 10.1155/2022/9103437
    RVK:
    QA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2187808-0
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  • 10
    Online Resource
    Online Resource
    The Impact of the Condenser on Cytogenetic Image Quality in Digital Microscope System
    Hindawi Limited ; 2013
    In:  Analytical Cellular Pathology Vol. 36, No. 1-2 ( 2013), p. 45-59
    Details
    In: Analytical Cellular Pathology, Hindawi Limited, Vol. 36, No. 1-2 ( 2013), p. 45-59
    Abstract: Background: Optimizing operational parameters of the digital microscope system is an important technique to acquire high quality cytogenetic images and facilitate the process of karyotyping so that the efficiency and accuracy of diagnosis can be improved. OBJECTIVE: This study investigated the impact of the condenser on cytogenetic image quality and system working performance using a prototype digital microscope image scanning system. Methods: Both theoretical analysis and experimental validations through objectively evaluating a resolution test chart and subjectively observing large numbers of specimen were conducted. Results: The results show that the optimal image quality and large depth of field (DOF) are simultaneously obtained when the numerical aperture of condenser is set as 60%–70% of the corresponding objective. Under this condition, more analyzable chromosomes and diagnostic information are obtained. As a result, the system shows higher working stability and less restriction for the implementation of algorithms such as autofocusing especially when the system is designed to achieve high throughput continuous image scanning. Conclusions: Although the above quantitative results were obtained using a specific prototype system under the experimental conditions reported in this paper, the presented evaluation methodologies can provide valuable guidelines for optimizing operational parameters in cytogenetic imaging using the high throughput continuous scanning microscopes in clinical practice.
    Type of Medium: Online Resource
    ISSN: 2210-7177 , 2210-7185
    URL: Article
    DOI: 10.1155/2013/261268
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2584078-2
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