In:
Epigenomics, Future Medicine Ltd, Vol. 12, No. 17 ( 2020-09), p. 1483-1499
Kurzfassung:
Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African–American adults in the Atherosclerosis Risk in Communities study. Materials & methods: We validated significantly associated cytosine–phosphate–guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.
Materialart:
Online-Ressource
ISSN:
1750-1911
,
1750-192X
DOI:
10.2217/epi-2019-0276
Sprache:
Englisch
Verlag:
Future Medicine Ltd
Publikationsdatum:
2020
SSG:
12
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