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  • 1
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    Image_3.JPEG
    Frontiers Media SA ; 2023
    In:  Frontiers in Microbiology Vol. 14 ( 2023-9-8)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-9-8)
    Abstract: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa , including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli , Klebsiella pneumoniae , Enterobacter cloacae complex, and Klebsiella aerogenes ) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018. Methods A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0. Results A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa , VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016. Discussion Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2023.1247804
    DOI: 10.3389/fmicb.2023.1247804.s001
    DOI: 10.3389/fmicb.2023.1247804.s002
    DOI: 10.3389/fmicb.2023.1247804.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587354-4
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  • 2
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    Data_Sheet_1.PDF
    Frontiers Media SA ; 2021
    In:  Frontiers in Marine Science Vol. 8 ( 2021-1-28)
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    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-1-28)
    Abstract: The protection of fish nurseries has been recognized as a useful tool to efficiently manage fisheries given that protected areas enhance the recruitment of target species. To identify and locate potential nursery areas, a solid understanding of species-environment relationships and their spatio-temporal dynamics is needed. Within this context, in this study we assess where European hake ( Merluccius merluccius ) recruits persistently aggregate in the northern continental shelf of the Iberian Peninsula. Hake recruit data collected during scientific trawl surveys between 2005 and 2016 were analyzed using Bayesian hurdle hierarchical spatio-temporal models, considering the environmental variables bathymetry, sea bottom temperature and salinity. Additionally, three different spatio-temporal structures (i.e., persistent, progressive, or opportunistic) were compared to assess the temporal persistence of nurseries over time. Among all the environmental variables analyzed, bathymetry was the most important. The preferential habitat of recruits was found to be within a bathymetric range of 120–200 m. Our findings clearly show that there is a temporally persistent main nursery located along the continental shelf of the Artabrian gulf (off La Coruña) in addition to several areas with high aggregations of hake recruits but with strong inter-annual variability. We argue that the analytical framework applied in this study allowed us to identify European hake nurseries in the northern continental shelf of the Iberian Peninsula, as well as their spatio-temporal fluctuations throughout the study period (2005–2016), and to assess which environmental factors, among bathymetry, sea bottom temperature and salinity, influence the occurrence and abundance of recruits in the study area. Results of our models also produce a new abundance index that could be useful for improving traditional stock assessment models.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    URL: Article
    DOI: 10.3389/fmars.2021.614675
    DOI: 10.3389/fmars.2021.614675.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2757748-X
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  • 3
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    DataSheet_1.pdf
    Frontiers Media SA ; 2021
    In:  Frontiers in Immunology Vol. 12 ( 2021-10-5)
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    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-10-5)
    Abstract: Autologous hematopoietic stem cell transplantation (autoHSCT) is a standard of care for transplant-eligible patients with multiple myeloma (MM). Among factors that influence outcome after autoHSCT, it has been suggested that the number of natural killer (NK) cells plays an important role. However, the impact that different NK cell subsets and their phenotype could have in disease progression after autoHSCT are less clear. For this reason, we have phenotypically and functionally characterized NK cells during immune system reconstitution after autoHSCT in 54 MM patients. Shortly after leukocyte recovery, an extensive redistribution of NK cell subsets occurs in these patients. In addition, NK cells undergo a profound phenotypic change characterized, among others, by their increased proliferative capacity and immature phenotype. Importantly, MM patients who showed lower frequencies of the mature highly differentiated NKG2A-CD57+ NK cell subset at +30 and +100 days after autoHSCT experienced superior progression-free survival and had a longer time to the next treatment than those with higher frequencies. Our results provide significant insights into NK cell reconstitution after autoHSCT and suggest that the degree of NK cell maturation after autoHSCT affects the clinical outcome of MM patients treated with this therapeutic strategy.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2021.748207
    DOI: 10.3389/fimmu.2021.748207.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 4
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    Involvement of Ceramide Metabolism in Cerebral Ischemia
    Frontiers Media SA ; 2022
    In:  Frontiers in Molecular Biosciences Vol. 9 ( 2022-4-20)
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    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 9 ( 2022-4-20)
    Abstract: Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in worldwide. Although reperfusion therapies have shown efficacy in a limited number of patients with acute ischemic stroke, neuroprotective drugs and recovery strategies have been widely assessed, but none of them have been successful in clinical practice. Therefore, the search for new therapeutic approaches is still necessary. Sphingolipids consist of a family of lipidic molecules with both structural and cell signaling functions. Regulation of sphingolipid metabolism is crucial for cell fate and homeostasis in the body. Different works have emphasized the implication of its metabolism in different pathologies, such as diabetes, cancer, neurodegeneration, or atherosclerosis. Other studies have shown its implication in the risk of suffering a stroke and its progression. This review will highlight the implications of sphingolipid metabolism enzymes in acute ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    DOI: 10.3389/fmolb.2022.864618
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2814330-9
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  • 5
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    DataSheet1.ZIP
    Frontiers Media SA ; 2022
    In:  Frontiers in Cell and Developmental Biology Vol. 10 ( 2022-6-28)
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    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 10 ( 2022-6-28)
    Abstract: The development of new biomarkers for human male infertility is crucial to improve the diagnosis and the prognosis of this disease. Recently, seminal microbiota was shown to be related to sperm quality parameters, suggesting an effect in human fertility and postulating it as a biomarker candidate. However, its relationship to sperm DNA integrity has not been studied yet. The aim of the present study is to characterize the seminal microbiota of a western Mediterranean population and to evaluate its relationship to sperm chromatin integrity parameters, and oxidative stress. For that purpose, 14 samples from sperm donors and 42 samples from infertile idiopathic patients were obtained and were analyzed to assess the composition of the microbiota through full-length 16S rRNA gene sequencing (Illumina MiSeq platform). Microbial diversity and relative abundances were compared to classic sperm quality parameters (macroscopic semen parameters, motility, morphology and concentration), chromatin integrity (global DNA damage, double-stranded DNA breaks and DNA protamination status) and oxidative stress levels (oxidation-reduction potential). The seminal microbiota observed of these samples belonged to the phyla Firmicutes , Proteobacteria , Actinobacteria and Bacteroidetes . The most abundant genera were Finegoldia , Peptoniphilus , Anaerococcus , Campylobacter , Streptococcus , Staphylococcus , Moraxella , Prevotella , Ezakiella , Corynebacterium and Lactobacillus . To our knowledge, this is the first detection of Ezakiella genus in seminal samples. Two clusters of microbial profiles were built based on a clustering analysis, and specific genera were found with different frequencies in relation to seminal quality defects. The abundances of several bacteria negatively correlate with the sperm global DNA fragmentation, most notably Moraxella , Brevundimonas and Flavobacterium . The latter two were also associated with higher sperm motility and Brevundimonas additionally with lower oxidative-reduction potential. Actinomycetaceae , Ralstonia and Paenibacillus correlated with reduced chromatin protamination status and increased double-stranded DNA fragmentation. These effects on DNA integrity coincide in many cases with the metabolism or enzymatic activities of these genera. Significant differences between fertile and infertile men were found in the relative presence of the Propionibacteriaceae family and the Cutibacterium , Rhodopseudomonas and Oligotropha genera, which supports its possible involvement in male fertility. Our findings sustain the hypothesis that the seminal microbiome has an effect on male fertility.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    URL: Article
    DOI: 10.3389/fcell.2022.937157
    DOI: 10.3389/fcell.2022.937157.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2737824-X
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  • 6
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    Table_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Ecology and Evolution Vol. 9 ( 2021-12-16)
    Details
    In: Frontiers in Ecology and Evolution, Frontiers Media SA, Vol. 9 ( 2021-12-16)
    Abstract: Farming impacts animal-mediated seed dispersal through mechanisms operating on at least two spatial scales. First, at the landscape scale, through habitat loss and land conversion to agriculture/livestock grazing, and second, at the farm scale, via a local intensification of agricultural practices. These two scales of farming impact seed dispersal function but have rarely been integrated. In particular, studies evaluating the effect of agriculture on the seed dispersal function of frugivorous birds in Mediterranean ecosystems are lacking. This study evaluates the role of landscape transformation, from fruit-rich woodland habitats to olive grove landscapes, together with local intensive practices of soil management on the persistence of the seed dispersal function for Mediterranean fleshy-fruited plants in olive landscapes of south Spain. We used bird censuses, mist-nets, and seed traps to characterize avian frugivore assemblages, frugivory, and seed deposition in the seminatural woodland habitat (SNWH) patches and olive fields of 40 olives farms spanning 20 localities distributed across the whole range of olive cultivation in Andalusia (southern Spain). We found that despite the remarkable dispersal function of olive grove landscapes, avian frugivore abundance and diversity, frugivory, and seed arrival decreased in olive fields compared to SNWH patches. Likewise, SNWH cover loss and/or olive growing expansion decreased avian frugivory and seed arrival. Interestingly, the habitat effects in the olive farms often depended on the landscape context. In particular, less diverse fruit-eating bird assemblages pooled in SNWH patches as olive grove cover increased or SNWH decreased in the landscape, while remaining relatively invariant in the olive fields. Finally, compared to conventional intensive agriculture, low-intensity management increased frugivory and seed deposition. We conclude that olive fields are less permeable to frugivores than expected due to the agroforest-like nature of these landscapes and that the presence of SNWH patches is crucial for the maintenance of frugivory and seed dispersal in agricultural landscapes. These results evidence that woodland habitat loss by olive expansion and intensive practices seriously threaten the dispersal service in olive-dominated landscapes. Maintenance, restoration, and promotion of woodland patches should be prioritized for the conservation of seed dispersal service and for enhancing the functional connectivity in human-shaped olive landscapes.
    Type of Medium: Online Resource
    ISSN: 2296-701X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fevo.2021.782462
    DOI: 10.3389/fevo.2021.782462.s001
    DOI: 10.3389/fevo.2021.782462.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2745634-1
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  • 7
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    Table_1.xlsx
    Frontiers Media SA ; 2021
    In:  Frontiers in Plant Science Vol. 12 ( 2021-8-19)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 12 ( 2021-8-19)
    Abstract: Quercus ilex L. is the dominant species in the Mediterranean forest and agrosilvopastoral ecosystem “ dehesa .” Currently, this forest species is threatened by natural and anthropogenic agents, especially by the decline syndrome, which is caused by Phytophthora cinnamomi and drought periods. Although the morphological and physiological responses of Q. ilex to combined stress ( P. cinnamomi and drought) have been examined already, little is known at the molecular level. In this study, we studied the effect and response of 8-month seedlings from three contrasting Andalusian populations (Seville [Se], Granada [Gr] , and Almeria [Al]) to the individual and combined stresses of P. cinnamomi and drought from morphological, physiological, biochemical, and proteomics data. Whereas, seedling damage (leaf chlorosis and necrosis) and mortality were greater under the combined stresses in the three populations, the effect of each individual stress was population-dependent. Resilient individuals were found in all the populations at different percentages. The decrease in leaf chlorophyll fluorescence, photosynthetic activity, and stomatal conductance observed in undamaged seedlings was greater in the presence of both stresses, the three populations responding similarly to drought and P. cinnamomi . Biochemical and proteomic analyses of undamaged seedlings from the two most markedly contrasting populations (Se and Al) revealed the absence of significant differences in the contents in photosynthetic pigments, amino acids, and phenolics among treatments. The Se and Al populations exhibited changes in protein profile in response to the different treatments, with 83 variable proteins in the former population and 223 in the latter. Variable proteins belonged to 16 different functional groups, the best represented among which were protein folding, sorting and degradation, carbohydrate, amino acid, and secondary metabolism, photosynthesis, and ROS scavenging. While photosynthetic proteins were mainly downaccumulated, those of stress-responsive were upaccumulated. Although no treatment-specific response was observed in any functional group, differences in abundance were especially marked under the combined stresses. The following variable proteins are proposed as putative markers for resilience in Q. ilex , namely, aldehyde dehydrogenase, glucose-6-phosphate isomerase, 50S ribosomal protein L5, and α-1,4-glucan-protein synthase [UDP-forming].
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2021.722802
    DOI: 10.3389/fpls.2021.722802.s001
    DOI: 10.3389/fpls.2021.722802.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 8
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    sTWEAK as Predictor of Stroke Recurrence in Ischemic Stroke Patients Treated With Reperfusion Therapies
    Frontiers Media SA ; 2021
    In:  Frontiers in Neurology Vol. 12 ( 2021-5-11)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 12 ( 2021-5-11)
    Abstract: Aim: The purpose of this study was to investigate clinical and neuroimaging factors associated with stroke recurrence in reperfused ischemic stroke patients, as well as the influence of specific biomarkers of inflammation and endothelial dysfunction. Methods: We conducted a retrospective analysis on a prospectively registered database. Of the 875 patients eligible for this study (53.9% males; mean age 69.6 ± 11.8 years vs. 46.1% females; mean age 74.9 ± 12.6 years), 710 underwent systemic thrombolysis, 87 thrombectomy and in 78, systemic or intra-arterial thrombolysis together with thrombectomy was applied. Plasma levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα) were analyzed as markers of inflammation, and soluble tumor necrosis factor-like inducer of apoptosis (sTWEAK) as an endothelial dysfunction marker. The main outcome variables of the study were the presence and severity of leukoaraiosis (LA) and stroke recurrence. Results: The average follow-up time of the study was 25 ± 13 months, during which 127 patients (14.5%) showed stroke recurrence. The presence and severity of LA was more severe in the second stroke episode (Grade III of the Fazekas 28.3 vs. 52.8%; p & lt; 0.0001). IL-6 levels at the first admission and before reperfusion treatment in patients with and without subsequent recurrence were similar (9.9 ± 10.4 vs. 9.1 ± 7.0 pg/mL, p = 0.439), but different for TNFα (14.7 ± 5.6 vs. 15.9 ± 5.7 pg/mL, p = 0.031) and sTWEAK (5,970.8 ± 4,330.4 vs. 8,660.7 ± 5,119.0 pg/mL, p & lt; 0.0001). sTWEAK values ≥7,000 pg/mL determined in the first stroke were independently associated to recurrence (OR 2.79; CI 95%: 1.87–4.16, p & lt; 0.0001). Conclusions: The severity and the progression of LA are the main neuroimaging factors associated with stroke recurrence. Likewise, sTWEAK levels were independently associated to stroke recurrence, so further studies are necessary to investigate sTWEAK as a therapeutic target.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    DOI: 10.3389/fneur.2021.652867
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2564214-5
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  • 9
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    Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
    Frontiers Media SA ; 2019
    In:  Frontiers in Neurology Vol. 10 ( 2019-4-17)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 10 ( 2019-4-17)
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    DOI: 10.3389/fneur.2019.00388
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2564214-5
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  • 10
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    Table_1.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Neurology Vol. 13 ( 2022-3-24)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 13 ( 2022-3-24)
    Abstract: This study aimed to explore the association between smoking habit and the serum levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK), in relation with the functional outcome of patients with acute ischemic stroke undergoing reperfusion treatment. Methods Observational and retrospective study of a series of patients with acute ischemic stroke subjected to reperfusion treatments. Clinical, analytical, and neuroimaging parameters were analyzed. The main endpoint was the functional outcome at 3 months, measured by the modified Ranking Scale (mRS). Logistic regression models were used to analyze the association between smoking and sTWEAK levels with functional outcome and leukoaraiosis. Results The results showed that smoking habit was associated with a good functional outcome at 3 months in patients with stroke (OR: 3.52; 95% CI: 1.03–11.9; p = 0.044). However, this independent association was lost after adjusting by sTWEAK levels (OR 1.73; 95% CI: 0.86–13.28; p = 0.116). sTWEAK levels were significantly lower in smoker patients [4015.5 (973.66–7921.83) pg/ml vs. 5,628 (2,848–10,202) pg/ml, p & lt; 0.0001], while sTWEAK levels were significantly higher in patients with poor functional outcomes at 3 months [10,284 (7,388–13.247) pg/ml vs. 3,405 (2,329–6,629) pg/ml, p & lt; 0.0001]. Conclusion The decrease in sTWEAK levels was associated with a good functional outcome in smoker patients with stroke undergoing reperfusion therapy.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    URL: Article
    DOI: 10.3389/fneur.2022.841484
    DOI: 10.3389/fneur.2022.841484.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564214-5
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