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  • 1
    ISSN: 1432-2013
    Keywords: Arterial pressure ; Plasma volume ; ECFV ; Interstitial fluid ; 131I-RISA ; 35S-Na2SO4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to examine the extrarenal roles of aldosterone in cardiovascular homeostasis, the present study compared blood pressure, extracellular fluid volume (ECFV) and plasma volume (PV) in the three following groups: 10 nephrectomized (NX) rats, 10 nephrectomized-adrenalectomized (NX-AX) rats, and 10 NX-AX and aldosterone-treated (NX-AX-A) rats. Two-hundred and fifty micrograms of aldosterone, mixed with sesame oil, was given subcutaneously in the NX-AX-A rats. Mean arterial pressure (MAP) was recorded through previously implanted carotid catheters. ECFV and PV were measured using35S-Na2SO4 and131I-RISA, respectively, 24 h after the operation. These measurements were performed in an unanesthetized and unrestricted condition. MAP gradually increased in the NX group, while a gradual decrease was observed in the other groups. However, MAP was significantly higher in the NX-AX-A group than in the NX-AX group 6 h after the operation and thereafter. Changes in body weight were comparable in the three groups 24 h after the operation. ECFV and PV were both reduced in the NX-AX and NX-AX-A groups as compared to the NX group (P〈0.001 NX-AX vs NX, andP〈0.05 andP〈0.025 NX-AX-A vs NX, respectively). Although ECFV was comparable in the NX-AX and the NX-AX-A groups, PV was significantly greater in the NX-AX-A group than in the NX-AX group (P〈0.05). There was a significant positive correlation between MAP and PV in the rats as a whole (r=0.68,P〈0.001). The area under the curve for plasma aldosterone concentration (PAC), which was estimated in a separate group, was similar in the NX and the NX-AX-A groups, but definitely decreased in the NX-AX group. Thus, it is suggested that aldosterone redistributed ECFV so as to maintain intravascular volume, contributing to attenuation of the fall in blood pressure occuring after adrenalectomy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7241
    Keywords: delapril ; ACE inhibitor ; depressor effect ; pharmacokinetics ; consecutive dose ; essential hypertension ; impaired renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antihypertensive effects and pharmacokinetic properties of delapril, an angiotensin-converting enzyme (ACE) inhibitor, were investigated in hypertensive patients with normal renal function (NRF; n=6) and in those with impaired renal function (IRF; n=5). A 15-mg oral dose of delapril was given once on the first and last days, and twice daily on the other days. The measurement of blood pressure and sampling were done at 0, 1, 2, 4, 6, 12, and 24 hours postdose on the first and last days of treatment. Plasma and urinary concentrations of delapril and its metabolites were measured by HPLC. ACE activity was suppressed from 1 hour after the first dose to 24 hours after the last dose of delapril in both the NRF and IRF groups. During the consecutive dosing, significant BP falls were observed from 1 hour postdose of delapril to 24 hours in the NRF group and to 6 hours in the IRF group. Peak plasma concentrations of 5-hydroxydelapril diacid and areas under the plasma concentration-time curve (AUC) of both delapril diacid and 5-hydroxydelapril diacid in the IRF group were significantly higher (p〈0.001 or 0.05) than in the NRF group. No significant increase of pharmacokinetic parameters in repeated dosing was observed in both the NRF and IRF groups. Significant positive correlations (p〈0.001) were found between the inverse of creatinine clearance and the AUCs of the active diacid metabolites in single and consecutive doses.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2021-04-21
    Description: We present a mapped climatology (GLODAPv2.2016b) of ocean biogeochemical variables based on the new GLODAP version 2 data product (Olsen et al., 2016; Key et al., 2015), which covers all ocean basins over the years 1972 to 2013. The quality-controlled and internally consistent GLODAPv2 was used to create global 1°  ×  1° mapped climatologies of salinity, temperature, oxygen, nitrate, phosphate, silicate, total dissolved inorganic carbon (TCO2), total alkalinity (TAlk), pH, and CaCO3 saturation states using the Data-Interpolating Variational Analysis (DIVA) mapping method. Improving on maps based on an earlier but similar dataset, GLODAPv1.1, this climatology also covers the Arctic Ocean. Climatologies were created for 33 standard depth surfaces. The conceivably confounding temporal trends in TCO2 and pH due to anthropogenic influence were removed prior to mapping by normalizing these data to the year 2002 using first-order calculations of anthropogenic carbon accumulation rates. We additionally provide maps of accumulated anthropogenic carbon in the year 2002 and of preindustrial TCO2. For all parameters, all data from the full 1972–2013 period were used, including data that did not receive full secondary quality control. The GLODAPv2.2016b global 1°  ×  1° mapped climatologies, including error fields and ancillary information, are available at the GLODAPv2 web page at the Carbon Dioxide Information Analysis Center (CDIAC; doi:10.3334/CDIAC/OTG.NDP093_GLODAPv2).
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
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  • 4
    Publication Date: 2021-04-21
    Description: Version 2 of the Global Ocean Data Analysis Project (GLODAPv2) data product is composed of data from 724 scientific cruises covering the global ocean. It includes data assembled during the previous efforts GLODAPv1.1 (Global Ocean Data Analysis Project version 1.1) in 2004, CARINA (CARbon IN the Atlantic) in 2009/2010, and PACIFICA (PACIFic ocean Interior CArbon) in 2013, as well as data from an additional 168 cruises. Data for 12 core variables (salinity, oxygen, nitrate, silicate, phosphate, dissolved inorganic carbon, total alkalinity, pH, CFC-11, CFC-12, CFC-113, and CCl 4) have been subjected to extensive quality control, including systematic evaluation of bias. The data are available in two formats: (i) as submitted but updated to WOCE exchange format and (ii) as a merged and internally consistent data product. In the latter, adjustments have been applied to remove significant biases, respecting occurrences of any known or likely time trends or variations. Adjustments applied by previous efforts were re-evaluated. Hence, GLODAPv2 is not a simple merging of previous products with some new data added but a unique, internally consistent data product. This compiled and adjusted data product is believed to be consistent to better than 0.005 in salinity, 1 % in oxygen, 2 % in nitrate, 2 % in silicate, 2 % in phosphate, 4 µmol kg −1 in dissolved inorganic carbon, 6 µmol kg −1 in total alkalinity, 0.005 in pH, and 5 % for the halogenated transient tracers.
    Type: Article , PeerReviewed
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  • 5
    Publication Date: 2023-02-08
    Description: The Global Ocean Data Analysis Project (GLODAP) is a synthesis effort providing regular compilations of surface-to-bottom ocean biogeochemical data, with an emphasis on seawater inorganic carbon chemistry and related variables determined through chemical analysis of seawater samples. GLODAPv2.2020 is an update of the previous version, GLODAPv2.2019. The major changes are data from 106 new cruises added, extension of time coverage to 2019, and the inclusion of available (also for historical cruises) discrete fugacity of CO2 (fCO2) values in the merged product files. GLODAPv2.2020 now includes measurements from more than 1.2 million water samples from the global oceans collected on 946 cruises. The data for the 12 GLODAP core variables (salinity, oxygen, nitrate, silicate, phosphate, dissolved inorganic carbon, total alkalinity, pH, CFC-11, CFC-12, CFC-113, and CCl4) have undergone extensive quality control with a focus on systematic evaluation of bias. The data are available in two formats: (i) as submitted by the data originator but updated to WOCE exchange format and (ii) as a merged data product with adjustments applied to minimize bias. These adjustments were derived by comparing the data from the 106 new cruises with the data from the 840 quality-controlled cruises of the GLODAPv2.2019 data product using crossover analysis. Comparisons to empirical algorithm estimates provided additional context for adjustment decisions; this is new to this version. The adjustments are intended to remove potential biases from errors related to measurement, calibration, and data-handling practices without removing known or likely time trends or variations in the variables evaluated. The compiled and adjusted data product is believed to be consistent to better than 0.005 in salinity, 1 % in oxygen, 2 % in nitrate, 2 % in silicate, 2 % in phosphate, 4 µmol kg−1 in dissolved inorganic carbon, 4 µmol kg−1 in total alkalinity, 0.01–0.02 in pH (depending on region), and 5 % in the halogenated transient tracers. The other variables included in the compilation, such as isotopic tracers and discrete fCO2, were not subjected to bias comparison or adjustments.
    Type: Article , PeerReviewed
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  • 6
    Publication Date: 2024-02-07
    Description: The Global Ocean Data Analysis Project (GLODAP) is a synthesis effort providing regular compilations of surface-To-bottom ocean biogeochemical bottle data, with an emphasis on seawater inorganic carbon chemistry and related variables determined through chemical analysis of seawater samples. GLODAPv2.2021 is an update of the previous version, GLODAPv2.2020 (Olsen et al., 2020). The major changes are as follows: data from 43 new cruises were added, data coverage was extended until 2020, all data with missing temperatures were removed, and a digital object identifier (DOI) was included for each cruise in the product files. In addition, a number of minor corrections to GLODAPv2.2020 data were performed. GLODAPv2.2021 includes measurements from more than 1.3 million water samples from the global oceans collected on 989 cruises. The data for the 12 GLODAP core variables (salinity, oxygen, nitrate, silicate, phosphate, dissolved inorganic carbon, total alkalinity, pH, CFC-11, CFC-12, CFC-113, and CCl4) have undergone extensive quality control with a focus on systematic evaluation of bias. The data are available in two formats: (i) as submitted by the data originator but updated to World Ocean Circulation Experiment (WOCE) exchange format and (ii) as a merged data product with adjustments applied to minimize bias. For this annual update, adjustments for the 43 new cruises were derived by comparing those data with the data from the 946 quality controlled cruises in the GLODAPv2.2020 data product using crossover analysis. Comparisons to estimates of nutrients and ocean CO2 chemistry based on empirical algorithms provided additional context for adjustment decisions in this version. The adjustments are intended to remove potential biases from errors related to measurement, calibration, and data handling practices without removing known or likely time trends or variations in the variables evaluated. The compiled and adjusted data product is believed to be consistent with to better than 0.005 in salinity, 1ĝ€¯% in oxygen, 2ĝ€¯% in nitrate, 2ĝ€¯% in silicate, 2ĝ€¯% in phosphate, 4ĝ€¯μmolkg-1 in dissolved inorganic carbon, 4ĝ€¯μmolkg-1 in total alkalinity, 0.01-0.02 in pH (depending on region), and 5ĝ€¯% in the halogenated transient tracers. The other variables included in the compilation, such as isotopic tracers and discrete CO2 fugacity (fCO2), were not subjected to bias comparison or adjustments. The original data, their documentation, and DOI codes are available at the Ocean Carbon Data System of NOAA NCEI (https://www.ncei.noaa.gov/access/ocean-carbon-data-system/oceans/GLODAPv2_2021/, last access: 7 July 2021). This site also provides access to the merged data product, which is provided as a single global file and as four regional ones-the Arctic, Atlantic, Indian, and Pacific oceans-under 10.25921/ttgq-n825 (Lauvset et al., 2021). These bias-Adjusted product files also include significant ancillary and approximated data and can be accessed via https://www.glodap.info (last access: 29 June 2021). These were obtained by interpolation of, or calculation from, measured data. This living data update documents the GLODAPv2.2021 methods and provides a broad overview of the secondary quality control procedures and results.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
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  • 7
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