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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 158 (1946), S. 238-238 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE rat is known to synthesize vitamin C in the course of its normal metabolism. It has been observed by Longenecker and associates1 that this synthesis can be greatly stimulated, resulting in the high urinary excretion of the vitamin, when the rats are given daily a variety of ...
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 53 (2001), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Morphological and functional heterogeneity of the splenic macrophage (Mφ) population was studied in Leishmania donovani (LD) infected BALB/c mice. On a discontinuous percoll gradient two distinct Mφ populations were separated. They differed significantly in size as evident from Scanning Electron Microscopy (SEM). Morphologically, the bigger Mφ (LM) showed surface projections, whereas the smaller Mφ (SM) was round. As regards the antigen-presenting abilities, the LM of infected animals showed defective antigen-presenting abilities at a later stage of the disease, i.e. 6 months post infection (6I-LM) but not earlier, whereas the SM population remained functionally intact throughout the course of the infection. Further, the 6I-LM showed a much enhanced Ad status as compared to their controls. Interestingly, both the 6I-LM and the control set showed a comparable level of binding of a known Ad restricted peptide. Despite the presence of sufficient Ad molecules and the ability to bind the appropriate peptide, 6I-LM were unable to stimulate peptide specific T-cell hybridoma. Further, the 6I-LM showed an increase in membrane fluidity and distorted morphology with membrane fissure and blebs as evident from SEM. It is possible that an increase in the membrane fluidity may lead to the defective antigen-presenting ability of 6I-LM. Thus, the LD infection functionally keep the 6I-LM out of antigen presentation and this may contribute to the defective cell mediated immune response in leishmaniasis.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The expression of chemokines and chemokine receptors was studied in Leishmania donovani (LD)-infected human mononuclear phagocytes and the human monocytic cell line THP1. Our studies showed that LD infection caused the upregulation of three β chemokines (macrophage inflammatory protein-1 alpha (MIP-1α), MIP-1β and RANTES (regulated on activation normal T cell expressed and secreted)), one α chemokine (interleukin-8 (IL-8)) and the CC chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. The CCR5 upregulation in human mononuclear phagocytes and THP1 cells was also evident by confocal microscopy. The possible association of such upregulation in relation to Leishmania and human immunodeficiency virus (HIV) coinfection was discussed.
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 39 (2000), S. 0 
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 43 (2004), S. 0 
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tetracyclines (TCN) were introduced in 1948 as broad-spectrum antibiotics that may be used in the treatment of many common infections in children and adults. One of the side-effects of tetracyclines is incorporation into tissues that are calcifying at the time of their administration. They have the ability to chelate calcium ions and to be incorporated into teeth, cartilage and bone, resulting in discoloration of both the primary and permanent dentitions. This permanent discoloration varies from yellow or gray to brown depending on the dose or the type of the drug received in relation to body weight. Minocycline hydrochloride, a semisynthetic derivative of tetracycline often used for the treatment of acne, has been shown to cause pigmentation of a variety of tissues including skin, thyroid, nails, sclera, teeth, conjunctiva and bone. Adult-onset tooth discoloration following long-term ingestion of tetracycline and minocycline has also been reported. The remarkable side-effect of minocycline on the oral cavity is the singular occurrence of “black bones”, “black or green roots” and blue-gray to gray hue darkening of the crowns of permanent teeth. The prevalence of tetracycline and minocycline staining is 3–6%. The mechanism of minocycline staining is still unknown. Most of the reviewed literature consisted of case reports; longitudinal clinical trials are necessary to provide more information on the prevalence, severity, etiology and clinical presentation of tetracycline and TCN-derivative staining in the adult population.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Two experiments assessed the effect of current and elevated levels of ultravioletB (UV-B) radiation on forage crop production. The effect of current levels of UV-B radiation was assessed by comparing the growth of eight cultivars of four legume and four grass species for three growing seasons (1994–96) under simulated sward conditions in the field. An exclusion system using cellulose diacetate or polyester covers provided comparable growing conditions for the plants, except for the presence or absence of ambient UV-B radiation, respectively. The second experiment studied the effect of elevated levels of UV-B on eight cultivars of two legume and two grass species in the greenhouse under simulated sward conditions. Natural lighting with sufficient supplemental light was used to provide ideal growing conditions for a 16-h day length. Separate sets of UV lights were installed to provide UV-B levels at approximately the same intensity as would be found in mid summer, and 33% and 66% more than this value. A fourth treatment consisted of removing UV-B radiation by using a polyester filter. Plant production was measured in both experiments. In 1994, field herbage yields from all young grass and legume seedlings were not significantly affected by the exclusion of ambient UV-B radiation, with the exception of alfalfa. Intra-specific variations with alfalfa yields were found for reduced levels of UV-B radiation. In general, these trends persisted as stands matured during two post seeding years. In the second experiment, no significant differences were observed for all tested species with increasing levels of UV-B radiation, except with some alfalfa cultivars and one birdsfoot trefoil cultivar. Collectively, these results demonstrate that in the northern latitudes young and mature plants of the studied species are resistant to current and potentially higher levels of solar UV-B radiation, with the exception of some alfalfa cultivars. The yield of these cultivars increased under enhanced levels of UV-B radiation in the greenhouse and decreased when UV-B was excluded in the field.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 326 (1987), S. 160-162 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Thinking that CS might be the C60 cluster 'buckminsterfuller-ene'5, we isolated a new sample from the Allende C3 V chondrite, aiming for maximum purity rather than maximum yield. After dissolving the major minerals in HF-HC1, we generated a colloid from the remaining 0.5% residue, leaving behind ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 255-255 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CLEAR taenite in meteorites1 contains 48-57% Ni and is optically anisotropic2, unlike taenite (? Fe,Ni) which is isotropic. We have proposed2 that clear taenite is composed of ordered FeNi, a phase first identified in iron meteorites by Albertsen et al.3. Mehta et al.4 have obtained additional ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 255 (1975), S. 289-292 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MANPOWER being an essential input for any developmental programme, India adopted in the post-independence years a programme of rapid expansion of education in science and technology to meet the requirements for development of science and technology. The number of universities was gradually ...
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 228 (1970), S. 589-589 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIB,-As the day of formal and wide acceptance of the decimal system draws closer, may I make a public request in favour of an Indian unit ? It is Laksha, written in English as Lakh, standing for 100,000. Surely, a lakh is a better way of saying one hundred thousand. Yours faithfully, S. ...
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