In:
Annual Review of Biophysics and Biomolecular Structure, Annual Reviews, Vol. 26, No. 1 ( 1997-06), p. 157-179
Abstract:
▪ Abstract Phospholamban is a 52-amino-acid protein that assembles into a pentamer in sarcoplasmic reticulum membranes. The protein has a role in the regulation of the resident calcium ATPase through an inhibitory association that can be reversed by phosphorylation. The phosphorylation of phospholamban is initiated by β-adrenergic stimulation, identifying phospholamban as an important component in the stimulation of cardiac activity by β-agonists. It is this role of phospholamban that has motivated studies in recent decades. There is evidence that phospholamban may also function as a Ca 2+ -selective ion channel. The structural properties of phospholamban have been studied by mutagenesis, modeling, and spectroscopy, resulting in a new view of the organization of this key molecule in membranes.
Type of Medium:
Online Resource
ISSN:
1056-8700
,
1545-4266
DOI:
10.1146/biophys.1997.26.issue-1
DOI:
10.1146/annurev.biophys.26.1.157
Language:
English
Publisher:
Annual Reviews
Publication Date:
1997
detail.hit.zdb_id:
2434740-1
detail.hit.zdb_id:
1473778-4
SSG:
12
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