In:
Materials Express, American Scientific Publishers, Vol. 12, No. 4 ( 2022-04-01), p. 592-598
Abstract:
Objective: To prepare docetaxel (DOC)-loaded methoxy polyethylene glycol-octacosanol (MPEG 2K -Oct) micelles and evaluate the in vitro and in vivo antitumor activity. Methods: DOC/MPEG-Oct was prepared using the thin-film hydration method. The physicochemical
property including size, zeta potential and drug release behavior were studies. The in vitro cytotoxicity and the in vivo antitumor activity were evaluated. Results: The prepared DOC/MPEG-Oct micelles had a small size, as well as high drug loading capacity and encapsulation
efficiency. These micelles also performed a sustained and controllable in vitro drug release. Besides, they showed a good inhibiting effect of tumor growth both in vitro and in vivo . Conclusion: DOC/MPEG-Oct nanomicelles might be considered as a safe and efficient
drug delivery system for DOC.
Type of Medium:
Online Resource
ISSN:
2158-5849
DOI:
10.1166/mex.2022.2174
Language:
English
Publisher:
American Scientific Publishers
Publication Date:
2022
detail.hit.zdb_id:
2905325-0
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