Publication Date:
2013-11-16
Description:
3-Oxotaraxer-14-en-30-al ( 1 ), a new taraxastane-type triterpene, together with 14 known compounds, taraxerone ( 2 ), 3-epiursolic acid ( 3 ), 2 α ,3 β -dihydroxyurs-12-en-28-oic acid ( 4 ), lupeol ( 5 ), betulinic acid ( 6 ), casticin ( 7 ), artemetin ( 8 ), luteolin ( 9 ), 4-hydroxybenzoic acid ( 10 ), docosanoic acid ( 11 ), tetracosanoic acid ( 12 ), cerotic acid ( 13 ), β -sitosterol ( 14 ), and β -daucosterol ( 15 ), was isolated from the leaves and twigs of Vitex trifolia var. simplicifolia . Compounds 2 – 6 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Cytotoxic activities of compounds 3 , and 5 – 10 were tested on the three cancer cell lines, PANC-1, K562, and BxPC-3. Results revealed that 7 exhibited cytotoxicity against PANC-1, K562, and BxPC-3, with IC 50 values of 4.67, 0.72, and 4.01 μg/ml, respectively, whereas 8 was inactive against these cancer cell lines. The structure activity relationship of compound 7 and 8 indicated that the 3′-OH group in polymethoxyflavonoids is essential for antitumor activity.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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