In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 202, No. 3 ( 1962-03-01), p. 429-436
Abstract:
The gastric H + secretory responses to i.v. HCl, NaHCO 3 , and acetazolamide were studied in Heidenhain-pouch dogs that had been stimulated to secrete by feeding. Acetazolamide in low doses (5 mg/kg) gave a 65% reduction in H + output for 2–4 hr, after which H + secretion increased above normal, coincident with renal HCO 3 – loss and metabolic acidosis. Higher doses produced a greater systemic acidosis and resulted in less initial reduction of H + and greater augmentation. Doses of 75–100 mg/kg, given 17 hr before feeding to produce a systemic acidosis, resulted in increased secretion, even though sufficient drug remained in the plasma to inhibit tissue carbonic anhydrase. Metabolic acidosis (i.v. HCl) initially suppressed but later augmented gastric H + . Acetazolamide had no suppressive effect in the presence of either an HCl- or acetazolamide-induced acidosis. Metabolic alkalosis (i.v. NaHCO 3 ) reduced gastric H + in regular feeding experiments and in dogs made acidotic by acetazolamide.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1962.202.3.429
Language:
English
Publisher:
American Physiological Society
Publication Date:
1962
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SSG:
12
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