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  • 1975-1979  (8)
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  • 1
    Electronic Resource
    Electronic Resource
    INHIBITION OF HERPESVIRUS DNA SYNTHESIS BY 9-β-D-ARABINOFURANOSYLADENINE IN CELLULAR AND CELL-FREE SYSTEMS 〈link href="#fn"〉*〈/link〉 (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 284 (1977), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1977.tb21935.x
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  • 2
    Electronic Resource
    Electronic Resource
    Benzo(a)pyrene monooxygenase induction in marine fish-molecular response to oil pollution (1977)
    Springer
    Marine biology 44 (1977), S. 211-216 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Induction of benzo (a) pyrene monooxygenase (BPMO) activity occurred in Blennius pavo, a species with a restricted territorial range, in response to exposure to a Diesel 2 oil. A response delay of 14 days was found at a concentration of 170 ppb and of 3 days when the water was saturated with Diesel 2 oil. When induced fish were transferred to clean water, elevated BPMO activity was maintained at a high level for at least a month. A benthic protochordate, Microcosmos sulcatus, showed no increase in BPMO activity when exposed to these concentrations even after 30 days of exposure. Field observations revealed a great variation in the BPMO activity from B. pavo caught at different sites. Fish from contaminated sites had significantly elevated levels of BPMO activity. Sardine schools caught at different sites had different, low levels of BPMO activities. However, specimens from the same school had closely similar levels of enzyme activity. An oil pollution incident (New Year 1977 oil spill in Northern Adriatic Sea) caused an increase in the BPMO activity in the livers of Blenniideae, reaching a peak on the 23rd day (representing an 8.5-fold increase in the background level), followed by a decrease in activity until a new background level, 3 times that of the original background level, was reached on the 45th day. This new background level is constant (through May-5 months after the incident). Measurement of BPMO activity in the livers of nonmigrant fish could serve as a useful biochemical parameter for monitoring and evaluation of acute or long-term oil pollution at a given site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387701
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  • 3
    Electronic Resource
    Electronic Resource
    Thymine content of sea water as a measure of biosynthetic potential (1977)
    Springer
    Marine biology 40 (1977), S. 1-8 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A hydrolysis procedure along with a high-pressure liquid chromatographic procedure is given enabling simple and reliable thymine determinations in the nanogram range in different fractions of sea-water samples taken from three different locations in the Northern Adriatic Sea. The levels corresponded to 1–3 μg DNA per liter. From total polyanionic thymine, which had been precipitated as the cetyltrimethylammonium salt, the highest percentage was linked to the particulate fraction, with a definite subsurface minimum at 10 to 15 m. There was a corresponding maximum of a high molecular “non-particulate” thymine-containing fraction at the corresponding depth. From the bottom at 30 m upwards to about 20 m, a low molecular thymine-containing material has been found. Remarkably these basic features were common to all three locations, one of which was supposed to be in clean water, one near a thickly settled, touristic area, and the other in front of a large river delta coming from industrial hinterland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390621
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of agents that act on DNA and RNA synthesis on the activity of poly(ADP-Rib) polymerase (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1014-1015 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The activity of poly(ADP-Rib) polymerase is enhanced in the presence of spermine and spermidine. Among the adenosine-like antibiotics tested, only formycin B and showdomycin cause an inhibition of the enzyme, which is competitive to NAD. The activity of poly(ADP-Rib) polymerase is not reduced by rifamycin, α-amanitin and 2-phenylthanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326930
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  • 5
    Electronic Resource
    Electronic Resource
    Induction of benzo (a)pyrene monooxygenase in fish and the salmonella test as a tool for detecting mutagenic/carcinogenic xenobiotics in the aquatic environment (1979)
    Springer
    Bulletin of environmental contamination and toxicology 21 (1979), S. 799-807 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01685508
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  • 6
    Electronic Resource
    Electronic Resource
    Methode zur Bestimmung der Bleomycin-inaktivierenden Enzymaktivität in Geweben (1975)
    Springer
    Journal of cancer research and clinical oncology 83 (1975), S. 151-162 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gewebe enthalten ein Enzym, das Bleomycin (BLM) inaktiviert. Die Enzymaktivität ist in Extrakten aus verschiedenen Geweben unterschiedlich hoch. In der vorliegenden Arbeit wird eine Methode zur Bestimmung der BLM-inaktivierenden Enzymaktivität aus Organen und Geweben von Mäusen beschrieben. Diese BLM-inaktivierende Enzymaktivität ist in Extrakten aus Leber am höchsten, Hoden, Milz, Lunge und Gehirn weisen geringere Aktivitäten auf; in Hautgewebe fehlt dieses Enzym fast völlig.
    Notes: Summary An enzyme that inactivates bleomycin (BLM) can be extracted from tissue. The activity of this enzyme varies markedly in different tissues. In the present paper, a method is described by which the activity of the BLM-inactivating enzyme in different organs and tissues of mice can be determined. The highest activity is found in liver; lower enzyme concentrations occur in the testis, spleen, lung and brain. In skin this enzyme is almost completely missing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282982
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  • 7
    Electronic Resource
    Electronic Resource
    Arabinose nucleoside triphosphates are no inhibitors for DNA-dependent RNA polymerases (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 1572-1573 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1-β-d-arabinofuranosylcytosine-5′-triphosphate and 9-β-d-arabinofuranosyladenosine-5′-triphosphate were found to have no inhibitory potency for both mammalian DNA-dependent RNA polymerase II andE. coli DNA-dependent RNA polymerase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01924459
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  • 8
    Electronic Resource
    Electronic Resource
    Bleomycin: Action on growth of oncogenic RNA viruses and on cell transformation (1975)
    Springer
    Archives of virology 48 (1975), S. 169-179 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bleomycin (BLM) inhibits cell proliferation of noninfected chick embryo fibroblasts by blocking their DNA synthesis selectively. Chick embryo fibroblasts have been transformed by Schmidt-Ruppin D strain of Rous Sarcoma Virus. Transformation has been determined by a focus assay. Foci formation is strongly reduced by BLM. Virus replication is inhibited by BLM in growing and confluent monolayer cells. This result might be explained by the observation that this drug reduces proliferation of growing and of confluent monolayer cells very sensitively. During the first 24 hours after infection the BLM inhibitory effect is more pronounced than in the case of BLM-application during the period 24–48 hours after infection. This result is explained by published results, showing that cell division is required only for the initiation of transcription of virus RNA but not for its maintenance. BLM has only little effect on virus growth in transformed cells, because in these cells initiation of transcription of virus RNA has already taken place before the drug was added. From the data obtained it is concluded, that BLM inhibits growth of Rous Sarcoma Virus by blocking cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318149
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