ISSN:
1432-2072
Keywords:
Analeptic drugs
;
Brain peptides
;
Melanocyte
;
Motor activity
;
Telemetry
;
Thyrotropin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Thyrotropin-releasing hormone (TRH), 0.1 mg/kg, i.m., significantly counteracted pentobarbital narcosis in six monkeys, but melanocyte-stimulating-hormone-release-inhibiting factor (MIF), 0.1 mg/kg i.m., did not. Earlier dose-response studies in unanesthetized monkeys had shown that this dose of MIF stimulated motor activity; this dose of TRH had shown no stimulant effect, but a higher dose depressed activity. Thus, an MIF dose that stimulates unanesthetized monkeys does not reverse pentobarbital narcosis; a TRH dose that by itself is neither stimulant nor depressant does partially reverse pentobarbital narcosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426494
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