In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 59, No. 8 ( 1981-08-01), p. 847-852
Abstract:
Colonic temperatures were measured in tailed and tailless rats at an ambient temperature (T a ) of 26 °C prior to and following administration of isoproterenol, a β-adrenergic agonist, at doses of 0, 12.5, 25.0, 50.0, and 100.0 μg∙kg −1 . There was no significant difference between the colonic temperatures of tailed and tailless rats before drug injection. However, mean colonic temperature of tailless rats increased to a maximal level approximately 0.3° higher than that of tailed rats after injection of 25.0, 50.0, and 100.0 μg isoproterenol per kilogram. The duration of the hyperthermic response was 50–60 min longer in tailless than tailed rats after administration of 50 and 100 μg isoproterenol per kilogram. The rate of oxygen consumption (heat production) increased by 4.5 mL∙min −1 ∙kg −0.75 in both tailed and tailless rats after administration of 50 μg isoproterenol per kilogram, the only dose tested. Mean colonic temperature of tailless rats was significantly higher, by 0.2–0.5°. than that of tailed rats during the initial 60 min of exposure to T a 36 °C and during the first 40 min following removal from T a 40 °C to T a 28 °C. These results suggest that the tail of the rat is required for short-term maintenance of colonic temperature during both external and internal heat stresses.
Type of Medium:
Online Resource
ISSN:
0008-4212
,
1205-7541
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
1981
detail.hit.zdb_id:
2004356-9
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