In:
Pathophysiology of Haemostasis and Thrombosis, S. Karger AG, Vol. 15, No. 3 ( 1985), p. 157-163
Abstract:
Heavy water (D 〈 sub 〉 2 〈 /sub 〉 O) is able to activate or to inhibit biological systems and thus influences metabolism and functions of tissues and organs. On the basis of results obtained in preservation experiments performed on various organs, the effects of D 〈 sub 〉 2 〈 /sub 〉 O on the functions of human platelets (retraction, spreading, aggregation induced by adrenaline, ADP and collagen) have been investigated. The effects of D 〈 sub 〉 2 〈 /sub 〉 O, involving changes of membrane receptor conformation, binding strength of substances to their specific receptors, pH-values or enzyme activities, resulted in a significant decrease of ADP- and collagen-induced aggregation, while adrenaline-induced aggregation was significantly increased at the same D 〈 sub 〉 2 〈 /sub 〉 O concentration. Retraction in the presence of D 〈 sub 〉 2 〈 /sub 〉 O was significantly inhibited in a dose-related manner, while spreading was diminished, but not fully inhibited even by highest concentrations of D 〈 sub 〉 2 〈 /sub 〉 O (95%).
Type of Medium:
Online Resource
ISSN:
1424-8832
,
1424-8840
Language:
English
Publisher:
S. Karger AG
Publication Date:
1985
detail.hit.zdb_id:
2081182-2
Permalink