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  • 1
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Microcin B17 (MccB17) is a ribosomally encoded DNA-gyrase inhibitor. Ribosomally encoded antibiotics are derived from precursors containing an N-terminal leader, which is removed during maturation, and a C-terminal structural peptide. PreMccB17, the translational product of mcbA, is modified into proMccB17 by the action of three enzymes, McbB, McbC, and McbD. A chromosomally encoded peptidase then converts proMccB17 into MccB17. The role of McbB, McbC, and McbD is to convert glycine, cysteine, and serine residues present in preMccB17 into four thiazole and four oxazole rings. Using a modification-specific antibody rather than antimicrobial activity, we show that the 26-amino-acid N-terminal leader of preMccB17 is essential for the conversion of preMccB17 into proMccB17. Neither a preMccB17 peptide lacking the leader nor a preMccB17–β-galactosidase fusion lacking the leader are post-translationally modified.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Blockage in myeloid differentiation characterizes acute myeloid leukemia (AML); the stage of the blockage defines distinct AML subtypes (AML1/2 to AML5). Differentiation therapy in AML has recently raised interest because the survival of AML3 patients has been greatly improved using the ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 2 (1995), S. 489-494 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The reductive unfolding of ribonuclease A with dithiothreitol proceeds through parallel pathways with the formation of two well-populated partially-unfolded three-disulphide intermediates. Two distinct local unfolding events rather than a global one are involved in the rate-limiting steps. These ...
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Aquatic geochemistry 1 (1995), S. 147-156 
    ISSN: 1573-1421
    Keywords: geochemistry ; mass balance ; chemical weathering ; mechanical denudation ; Changhuajiang River watershed
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Based on the geological background, R-mode factor statistics, and the analysis of the stability diagram for the corresponding system, five weathering reactions controlling the surface-water chemical composition in the watershed of the Changhuajiang River are deduced. In the mass balance model, the precipitation accounts for some solute input, since the rainwater is dilute without pollution. Most of the Ca2+ and HCO 3 − ions are from the dissolution of calcite, K+, Na+, H4SiO4 and some of the Mg2+ and HCO 3 − come from albite and biotite weathering to kaolinite. The dissolution of dolomite and gypsum controls the mass balances of Mg2+ and SO 4 2− . The dissolution of calcite is the dominant chemical weathering reaction in the watershed because of its reactivity and high concentration. In the watershed in 1986, the chemical weathering rate was 0.073 (kg/m2 a), and the mechanical denudation rate is 0.093 (kg/m2 a). The chemical weathering mass output proportion of carbonate rocks to silicate rocks was about three to one.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 7 (1996), S. 47-49 
    ISSN: 1042-7147
    Keywords: oxygenation ; benzyl alcohol ; polytitanzane-platinum complex ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: An inorganic polymer-platinum complex, magnesiasupported polytitanzane-platinum complex (MgO—Ti—N—Pt), was prepared and used to catalyze the oxygenation of benzyl alcohol. It was found that this kind of catalyst has great activity and stability in the reaction. The objective product (benzaldehyde) was obtained in 100% yield in 6 hr under a moderate reaction temperature and atmospheric oxygen pressure. This inorganic polymer complex was also very stable during the reaction.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 7 (1996), S. 726-728 
    ISSN: 1042-7147
    Keywords: diphenyl methanol ; oxygenation ; polytitazane-platinum complex ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Magnesium oxide-supported polytitazane-platinum complex has been found to catalyze the oxygenation of diphenyl methanol with high yield and high selectivity at 140°C and 1 atm O2. The N/Pt molar ratio, temperature and solvent had great influence on the activity of the catalyst.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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