In:
HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery, SAGE Publications, Vol. 5, No. 1 ( 2009-02), p. 49-50
Abstract:
The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.
Type of Medium:
Online Resource
ISSN:
1556-3316
,
1556-3324
DOI:
10.1007/s11420-008-9091-6
Language:
English
Publisher:
SAGE Publications
Publication Date:
2009
detail.hit.zdb_id:
2210985-7
Permalink