In:
Journal of Applied Physiology, American Physiological Society, Vol. 107, No. 4 ( 2009-10), p. 1235-1240
Abstract:
The present study examined associations between the ciliary neurotrophic factor (CNTF) 1357 G → A polymorphism and the muscle strength response to a unilateral, upper arm resistance-training (RT) program among healthy, young adults. Subjects were 754 Caucasian men (40%) and women (60%) who were genotyped and performed a training program of the nondominant (trained) arm with the dominant (untrained) arm as a comparison. Peak elbow flexor strength was measured with one repetition maximum, isometric strength with maximum voluntary contraction, and bicep cross-sectional area with MRI in the trained and untrained arms before and after training. Women with the CNTF GG genotype gained more absolute isometric strength, as measured by MVC (6.5 ± 0.3 vs. 5.2 ± 0.5 kg), than carriers of the CNTF A1357 allele in the trained arm pre- to posttraining ( P 〈 0.05). No significant associations were seen in men. Women with the CNTF GG genotype gained more absolute dynamic (1.0 ± 0.1 vs. 0.6 ± 0.1 kg) and allometric (0.022 ± 0.0 vs. 0.015 ± 0.0 kg/kg −0.67 ) strength, as measured by 1 RM, than carriers of the CNTF A1357 allele in the untrained arm pre- to posttraining ( P 〈 0.05). No significant associations were seen in men. No significant associations, as measured by cross-sectional area, were seen in men or women. The CNTF 1357 G → A polymorphism explains only a small portion of the variability in the muscle strength response to training in women.
Type of Medium:
Online Resource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/japplphysiol.90835.2008
Language:
English
Publisher:
American Physiological Society
Publication Date:
2009
detail.hit.zdb_id:
1404365-8
SSG:
12
SSG:
31
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