In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1112, No. 1 ( 2007-09), p. 219-224
Abstract:
Abstract : The aim of this study was to evaluate the possible neuroprotective effects of thymosin β 4 in different models of excitotoxicity. The application of thymosin β 4 significantly attenuated glutamate‐induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β 4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β 4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β 4 , are worthy of further investigations.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1415.033
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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