Publication Date:
2016-06-03
Description:
This meta-analysis was to evaluate the efficacy of current treatment modalities for kaposiform hemangioendothelioma and tufted angioma. A systematic review was performed using PubMed (Medline), Web of Science and Embase for clinical studies. The outcome was measured by pooled response rate with 95% confidence intervals (CIs), together with heterogeneity, subgroup analysis, sensitivity analysis and publication bias. 15 studies with 244 participants were included in this analysis. Vincristine therapy exhibited a relatively higher response rate (0.72; 95% CI , 0.64-0.79) compared with other therapies including systemic corticosteroid (0.27; 95% CI , 0.17-0.36), interferon (0.36; 95% CI , 0.24-0.48), radiotherapy (0.49; 95% CI , 0.26-0.73), embolization (0.66; 95% CI , 0.48-0.83), aspirin/ticlopidine (0.42; 95% CI , 0.06-0.78), and sirolimus (0.57; 95% CI , 0.00-0.10), in treating KHE/TA. Subgroup analysis indicated that the efficacy of systemic corticosteroids therapy was age-related. The pooled response rate was 0.15 (95% CI , 0.08-0.23) for participants3.5 months of age and older compared with 0.35 (95% CI , 0.26-0.44) for participants less than 3.5 months. Regarding side effects, systemic corticosteroids treatment was 0.32 (95% CI , 0.15-0.50), vincristine modality was 0.16 (95% CI , 0.08-0.24), and interferon therapy was 0.28 (95% CI , 0.13-0.43). In conclusion, as one of the first reviews evaluating the effect of common therapies in the treatment of KHE/TA, our meta-analysis displayed that vincristine was more effective. Thus, vincristine was the most effective, providing evidence supporting the use of vincristine as a first-line therapy for KHE/TA. This article is protected by copyright. All rights reserved.
Print ISSN:
0020-7136
Electronic ISSN:
1097-0215
Topics:
Biology
,
Medicine
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