Description: Since about 15 years a growing number of evidence is found in water depth up to more than 1000 m of the Arctic Ocean that grounding of ice has occurred in various places including the "Beringian" continental margin north of the present Chukchi and East-Siberian seas and the Lomonosov Ridge. These landforms include moraines, drumlinized features, glacigenic debris flows, till wedges, mega-scale glacial lineations (MSGL), and iceberg plough marks (Polyak et al. 2001, Niessen et al. 2013, Dove et al. 2014, Jakobsson et al. 2014). They suggest that thick ice has occurred not only on nearly all margins of the Arctic Ocean but also covered pelagic areas. In a recent paper, Jakobsson et al. (2016) present more evidence of ice-shelf groundings on bathymetric highs in the central Arctic Ocean, thereby revitalising an old modelling concept of a kilometre-thick ice shelf extending over the entire central Arctic Ocean (Hughes et al. 1977) now dated to Marine Isotope Stage (MIS) 6. Other (including our) studies, however, suggest that the pattern, and, in particular, the timing of these glaciations is more complex. Most recent discoveries on the Lomonosov Ridge have not only gained different information on Pleistocene glaciations but also allowed for the first time to reconstruct upper Miocene Arctic Ocean sea-ice and SST conditions. This became possible since submarine sliding (likely associated with ice grounding) led to removal of younger sediments from steep headwalls and thus exhumation of Miocene to early Quaternary sediments close to the seafloor, allowing the retrieval and analysis of such old sediments by gravity coring (Stein et al. 2016). Submarine glacial landforms from the western and central Arctic Ocean were discovered and investigated during the cruises of RV "Polarstern" in 2008 and 2014, and RV "Araon" in 2012 and 2015. Orientations of some of these landforms suggest that thick ice has flown north into the deep Arctic Ocean from the continental margin of the East Siberian Sea repeatedly (Niessen et al. 2013), thereby grounded on plateaus and seamounts of the Medeleev Ridge. In addition, hydro-acoustic data is presented from the Lomonosov Ridge (Siberian side to close to the North Pole), which support the hypothesis of widespread grounding of ice in the Arctic Ocean, of which the sources are still difficult to determine. The data suggest that thick ice-shelves could have developed from continental ice sheets on a nearly circum-arctic scale, which disintegrated into large icebergs during glacial terminations. On the slopes of the East Siberian Sea and/or on the Arlis Plateau, three northerly-directed ice advances occurred, which are dated by sediment cores using the chronology of brown layers (B1 to B7) as suggested by Stein et al. (2010). According to our age model, the latest advance is slightly older than B2 (MIS-3/4), which has been interpreted as MIS-6 by Jakobsson et al. (2016). A larger well-constrained glaciation has occurred during MIS-4, of which an ice shelf grounded to 900 m on the Arlis Plateau. In the western Arctic Ocean, the oldest datable ice advance has an intra-MIS-5 age. In our data, the chronology of older ice advances along the East Siberian margin are not well constrained but may extend back as far as MIS-16. In contrast, cores from the southern and central Lomonosov Ridge indicate that the youngest ice grounding there has occurred during MIS-6. This grounding was less intense than previous ice-shelf groundings in the area, of which the chronology remains speculative until longer cores become available. Along the Lomonosov Ridge, detailed bathymetric mapping between 81° and 84°N exhibit numerous amphitheatre-like slide scars, under which large amounts of Cenozoic sediments were remobilized into mass-wasting features on both the Makarov and Amundsen sides of the ridge. In areas shallower than 1000 metres, slide scars appear to be associated with streamlined glacial lineations, whereby some of the bedforms have been removed by sliding. It appears that at least some of the mass-wasting events have been triggered by moving and/or loading of grounded ice. Sub-bottom seismic profiling discovered at least three generations of debris-flow deposits near the ridge, which were generated by the slides. In places, the nearly randomly distributed slide scars and debris-flow deposits make it hard to interpret past ice-flow directions from landforms and re-deposited sediments. The pattern allows interpretation of both directions off East Siberia (e.g. Jakobsson et al. 2016) and off Eurasia (e.g. Polyak et al. 2001) towards the central Arctic Ocean. Underneath the slide scars escarpments of up to 400 m in height were formed. Near the southern end of the Lomonosov Ridge the last exhumation of old sediments has occurred during MIS-6. Some of the old sediments recovered in 2014 were studied in more detail (Stein et al., 2016). We can show for the first time that the mid/late Miocene central Arctic Ocean was relatively warm (4-7°C) and ice-free during summer, but sea ice occurred during spring and autumn/winter. A comparison of our biomarker proxy data with Miocene climate simulations seems to favour relatively high late Miocene atmospheric CO2 concentrations. References Dove, D., Polyak, L. & Coakley, B., 2014. Widespread, multi-source glacial erosion on the Chukchi margin, Arctic Ocean. Quat. Sci. Rev. 92, 112–122 Hughes, T. J., Denton, G. H. & Grosswald, M. G., 1977. Was there a late-Würm Arctic ice sheet? Nature, 266, 596–602 Jakobsson, M. et al., 2014. Arctic Ocean glacial history. Quat. Sci. Rev. 92, 40-67 Jakobsson, M., et al., 2016. Evidence for an ice shelf covering the central Arctic Ocean during the penultimate glaciation. Nat. Comm., 7, 10365, DOI: 10.1038/ncomms10365, 1-10 Niessen, F. et al., 2013. Repeated Pleistocene glaciation of the East Siberian continental margin. Nat. Geosci. 6, 842–846 Polyak, L., Edwards, M. H., Coakley, B. J. & Jakobsson, M., 2001. Ice shelves in the Pleistocene Arctic Ocean inferred from glaciogenic deep-sea bedforms. Nature 410, 453–459 Stein, R., Matthiessen, J., Niessen, F., Krylov, A., Nam, S., Bazhenova, E., 2010. Towards a better (litho-) stratigraphy and reconstruction of Quaternary paleoenvironment in the Amerasian Basin (Arctic Ocean), Polarforschung, 79 (2), 97-121 Stein, R., K. Fahl, Schreck, M., Knorr, G., Niessen, F., Forwick, M., Gebhardt, C., Jensen, L., Kaminski, M., Kopf, A., Matthiessen, J., Jokat, W., and Lohmann, G., 2016. Evidence for ice-free summers in the late Miocene central Arctic Ocean. Nature Communications 7:11148, doi:10.1038/ncomms11148.

Description: The Hovgård Ridge is situated in Fram Strait, west of Spitsbergen. The ridge either represents a submerged fragment of continental crust or an upwarped fragmant of ocean crust within the Fram Strait. Its crest rises to a water depth of approx. 1170 m. During Expedition 87 of the Icebreaker POLARSTERN in August 2014, a sedimentechosounding profile was recorded and a boxcore station was collected from the crest of Hovgård Ridge at 1169 m water depth. The surficial sediment at this station consists of dark yellowish brown pebbly-sandy mud with a minor admixture of biogenic components in the coarse fraction. Patches of large tubular foraminifera and isolated pebbles were clearly visible on the sediment surface. The sediment surface of the boxcore was covered with patches of large (〉1 mm diameter) large tubular astrorhizids belonging mostly to the species Astrorhiza crassatina Brady, with smaller numbers of Saccorhiza, Hyperammina, and Psammosiphonella. Non-tubular species consist mainly of opportunistic forms such as Psammosphaera and Reophax. The presence of large suspension-feeding tubular genera as well as opportunistic forms, as well as sediment winnowing, point to the presence of a deep current at this locality that is strong enough to disturb the benthic fauna. This is confirmed by data obtained from sediment echosounding, which exhibit lateral variation of relative sedimentation rates within the Pleistocene sedimentary drape covering the ridge indicative of winnowing in a south-easterly direction.

Description: Eighty species and morphological varieties of agglutinated benthic foraminifera were identified in sediments from the HEBBLE Site (4800 m depth) and the HEBBLE Shallow Site (4185 m) on the lower Nova Scotian Continental Rise. Details of their morphology and classification are included in descriptions of each species, and representative specimens are illustrated using SEM, light microscopy, and X-radiography.

Description: Prepared for the Office of Naval Research under Contract N00014 -82-C-0019.

Description: We present the first comparison between new fAPAR and LAI products derived from the GlobAlbedo dataset and the widely-used MODIS fAPAR and LAI products. The GlobAlbedo-derived products are produced using a 1D two-stream radiative transfer (RT) scheme designed explicitly for global parameter retrieval from albedo, with consistency between RT model assumptions and observations, as well as with typical large-scale land surface model RT schemes. The approach does not require biome-specific structural assumptions (e.g., cover, clumping, understory), unlike more detailed 3D RT model approaches. GlobAlbedo-derived values of fAPAR and LAI are compared with MODIS values over 2002–2011 at multiple flux tower sites within selected biomes, over 1200 × 1200 km regions and globally. GlobAlbedo-derived fAPAR and LAI values are temporally more stable than the MODIS values due to the smoothness of the underlying albedo, derived via optimal estimation (assimilation) using an a priori estimate of albedo derived from an albedo “climatology” (composited multi-year albedo observations). Parameters agree closely in timing but with GlobAlbedo values consistently lower than MODIS, particularly for LAI. Larger differences occur in winter (when values are lower) and in the Southern hemisphere. Globally, we find that: GlobAlbedo-derived fAPAR is ~0.9–1.01 × MODIS fAPAR with an intercept of ~0.03; GlobAlbedo-derived LAI is ~0.6 × MODIS LAI with an intercept of ~0.2. Differences arise due to the RT model assumptions underlying the products, meaning care is required in interpreting either set of values, particularly when comparing to fine-scale ground-based estimates. We present global transformations between GlobAlbedo-derived and MODIS products.

Description: A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target, Published online: 03 September 2018; doi:10.1038/s41467-018-06008-4 The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy.