Publication Date:
2018-04-07
Description:
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements, Published online: 06 April 2018; doi:10.1038/s41467-018-03780-1 Glucocorticoid receptor (GR) regulates immunity and inflammation but the mechanisms by which GR represses proinflammatory genes are still being debated. Here the authors use a multidisciplinary approach and show that GR binds to a cryptic site within genome-wide NFκB DNA response elements to repress pro-inflammatory genes.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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