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  • 1
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    Online Resource
    WITHDRAWN–Administrative Duplicate Publication A case of fat embolism syndrome accompanying diffuse alveolar hemorrhage
    Wiley ; 2018
    In:  Hong Kong Journal of Emergency Medicine Vol. 25, No. 3 ( 2018-05), p. 160-162
    Details
    In: Hong Kong Journal of Emergency Medicine, Wiley, Vol. 25, No. 3 ( 2018-05), p. 160-162
    Type of Medium: Online Resource
    ISSN: 1024-9079 , 2309-5407
    URL: Article
    DOI: 10.1177/1024907917745664
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2917387-5
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  • 2
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    Impact of clinically evident portal hypertension on clinical outcome of patients with hepatocellular carcinoma treated by transarterial chemoembolization
    Wiley ; 2018
    In:  Journal of Gastroenterology and Hepatology Vol. 33, No. 7 ( 2018-07), p. 1397-1406
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 33, No. 7 ( 2018-07), p. 1397-1406
    Abstract: The aim of this study is to determine the impact of clinically evident portal hypertension (CEPH) on prognosis of hepatocellular carcinoma (HCC) patients with Child–Pugh A cirrhosis who underwent transarterial chemoembolization (TACE). Methods A retrospective data analysis was performed for a total of 388 treatment‐naïve HCC patients with Child–Pugh A cirrhosis who underwent TACE as first‐line treatment from January 2000 to June 2014. Cumulative occurrence rate of complete response (CR), progression‐free survival (PFS), and overall survival (OS) were compared between patients with CEPH and those without CEPH (esophageal/gastric varices or low platelet count [ 〈  100 000 per mm 3 ] associated with splenomegaly). Results Among 388 patients, 252 (64.9%) had CEPH, while 136 (35.1%) had no evidence of CEPH at the time of HCC diagnosis. Cumulative probability of the occurrence of CR was significantly lower in patients with CEPH than that in patients without CEPH ( P   〈  0.001). Median PFS was significantly shorter in patients with CEPH than that in patients without CEPH (5 vs 31 months, P   〈  0.001). Five‐year OS rate was significantly lower in patients with CEPH than that in patients without CEPH (41.5% vs 77.5%, P   〈  0.001). Multivariate analysis indicated that the presence of CEPH was the most powerful poor prognostic factor for the occurrence of CR (adjusted hazard ratio [aHR], 0.16; 95% confidence interval [CI] , 0.09–0.28; P   〈  0.001), PFS (aHR, 5.01; 95% CI, 3.08–8.12; P   〈  0.001), and OS (aHR, 2.95; 95% CI, 1.66–5.23; P   〈  0.001). Conclusions The presence of CEPH should be considered as a major negative prognostic factor for patients with HCC who will undergo TACE.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2018.33.issue-7
    DOI: 10.1111/jgh.14083
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2006782-3
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  • 3
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    Association between cotinine‐verified smoking status and risk of nonalcoholic fatty liver disease
    Wiley ; 2018
    In:  Liver International Vol. 38, No. 8 ( 2018-08), p. 1487-1494
    Details
    In: Liver International, Wiley, Vol. 38, No. 8 ( 2018-08), p. 1487-1494
    Abstract: The relationship between cigarette smoking and nonalcoholic fatty liver disease ( NAFLD ) has been controversial. Most relevant studies have relied on self‐reported questionnaires. We aimed to elucidate the association between smoking status and NAFLD using an objective biomarker of tobacco exposure (urinary cotinine) and self‐reported questionnaire. Methods A cross‐sectional study was conducted on 160 862 asymptomatic examinees who underwent abdominal ultrasonography and urinary cotinine measurements between April 2011 and December 2015. Cotinine‐verified current smokers were defined as participants with urinary cotinine levels ≥50 ng/ mL . Results The mean age of the study population was 36.1 years, and the proportion of men was 51.7%. The proportions of self‐reported and cotinine‐verified current smokers were 17.6% and 17.7% respectively. After adjusting for confounding factors, self‐reported current smoking was associated with an increased risk of NAFLD (adjusted odds ratio [ AOR ], 1.10; 95% confidence interval [ CI ], 1.06‐1.14). Moreover, among the current smokers, the risk of NAFLD increased with an increase in the amount of cigarette smoking ( 〈 10 and ≥10 pack‐years vs never smokers; AOR , 1.04 and 1.11; 95% CI , 1.01‐1.08 and 1.05‐1.16 respectively). Cotinine‐verified current smoking was also associated with an increased risk of NAFLD ( AOR , 1.10; 95% CI , 1.06‐1.14). Conclusions Cotinine‐verified current smoking and self‐reported current smoking were independent risk factors for NAFLD . Further longitudinal studies are needed to more clearly elucidate the impact of smoking on the development of NAFLD .
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.2018.38.issue-8
    DOI: 10.1111/liv.13701
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2124684-1
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  • 4
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    Assessment of the accuracy and stability of frameless gamma knife radiosurgery
    Wiley ; 2018
    In:  Journal of Applied Clinical Medical Physics Vol. 19, No. 4 ( 2018-07), p. 148-154
    Details
    In: Journal of Applied Clinical Medical Physics, Wiley, Vol. 19, No. 4 ( 2018-07), p. 148-154
    Abstract: The aim of this study was to assess the accuracy and stability of frameless gamma knife radiosurgery ( GKRS ). The accuracies of the radiation isocenter and patient couch movement were evaluated by film dosimetry with a half‐year cycle. Radiation isocenter assessment with a diode detector and cone‐beam computed tomography ( CBCT ) image accuracy tests were performed daily with a vendor‐provided tool for one and a half years after installation. CBCT image quality was examined twice a month with a phantom. The accuracy of image coregistration using CBCT images was studied using magnetic resonance ( MR ) and computed tomography ( CT ) images of another phantom. The overall positional accuracy was measured in whole procedure tests using film dosimetry with an anthropomorphic phantom. The positional errors of the radiation isocenter at the center and at an extreme position were both less than 0.1 mm. The three‐dimensional deviation of the CBCT coordinate system was stable for one and a half years (mean 0.04 ± 0.02 mm). Image coregistration revealed a difference of 0.2 ± 0.1 mm between CT and CBCT images and a deviation of 0.4 ± 0.2 mm between MR and CBCT images. The whole procedure test of the positional accuracy of the mask‐based irradiation revealed an accuracy of 0.5 ± 0.6 mm. The radiation isocenter accuracy, patient couch movement accuracy, and Gamma Knife Icon CBCT accuracy were all approximately 0.1 mm and were stable for one and a half years. The coordinate system assigned to MR images through coregistration was more accurate than the system defined by fiducial markers. Possible patient motion during irradiation should be considered when evaluating the overall accuracy of frameless GKRS .
    Type of Medium: Online Resource
    ISSN: 1526-9914 , 1526-9914
    URL: Issue
    URL: Article
    DOI: 10.1002/acm2.2018.19.issue-4
    DOI: 10.1002/acm2.12365
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2010347-5
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  • 5
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    Hydrogen‐Bonding‐Driven Enantioselective Resolution against the Kazlauskas Rule To Afford γ‐Amino Alcohols by Candida rugosa Lipase
    Wiley ; 2015
    In:  ChemBioChem Vol. 16, No. 1 ( 2015-01-02), p. 77-82
    Details
    In: ChemBioChem, Wiley, Vol. 16, No. 1 ( 2015-01-02), p. 77-82
    Abstract: Most lipases resolve secondary alcohols in accordance with the “Kazlauskas rule” to give the R enantiomers. In a similar manner to other lipases, Candida rugosa lipase (CRL) exhibits R enantioselectivity towards heptan‐2‐ol, although the enantiomeric ratio ( E ) is low ( E =1.6). However, unexpected enantioselectivity (i.e., S enantioselectivity, E =58) of CRL towards 4‐( tert ‐butoxycarbonylamino)butan‐2‐ol, which has a similar chain length to heptan‐2‐ol, has been observed. To develop a deeper understanding of the molecular basis for this unusual enantioselectivity, we have conducted a series of molecular modeling and substrate engineering experiments. The results of these computational and experimental analyses indicated that a hydrogen bond between the Ser450 residue and the nitrogen atom of the carbamate group is critical to stabilize the transition state of the S enantiomer.
    Type of Medium: Online Resource
    ISSN: 1439-4227 , 1439-7633
    URL: Issue
    URL: Article
    DOI: 10.1002/cbic.v16.1
    DOI: 10.1002/cbic.201402563
    RVK:
    VA 2918
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2020469-3
    SSG: 12
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  • 6
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    External validation of the non‐alcoholic fatty liver disease fibrosis score for assessing advanced fibrosis in Korean patients
    Wiley ; 2017
    In:  Journal of Gastroenterology and Hepatology Vol. 32, No. 5 ( 2017-05), p. 1094-1099
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 32, No. 5 ( 2017-05), p. 1094-1099
    Abstract: The degree of liver fibrosis in non‐alcoholic fatty liver disease (NAFLD) is a critical predictive factor for patient prognosis. This study was intended to perform external validation of the various fibrosis prediction models for assessing advanced fibrosis in Korean NAFLD patients. Methods A retrospective study of 412 patients with NAFLD confirmed by liver biopsy in hospitals affiliated with the Koran NAFLD study group was conducted and the predictive ability of existing liver fibrosis prediction models including NAFLD fibrosis score (NFS), BARD, and fibrosis‐4 were compared. Results Among 412 samples, 328 liver slides were suitable for evaluation. Advanced fibrosis was present in 60 (18.3%) of the patient samples. Univariate analysis found that the group with advanced fibrosis showed low alanine aminotransferase values and high aspartate aminotransferase/alanine aminotransferase ratios as well as a high incidence of diabetes. However, multivariate analysis showed that only the presence of diabetes and triglycerides was independent risk factors. The receiver operating characteristic was 0.64 in NFS, 0.58 in fibrosis‐4, and 0.594 in the BARD model. The NFS was found to be the best at predicting advanced fibrosis among the three prediction models. The negative predictive value which predicts advanced fibrosis using the low cutoff ( 〈 −1.455) was high (86.6%). However, the positive predictive value which predicts advanced fibrosis using the high cutoff ( 〉 0.676) was 50.0% when we applied the NFS. Conclusion Negative predictive value using the low cutoff value was high, but positive predictive value using the high cutoff value was low in a Korean NAFLD cohort using NFS.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2017.32.issue-5
    DOI: 10.1111/jgh.13648
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2006782-3
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  • 7
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    Incidence and risk factors of postoperative pneumonia following cancer surgery in adult patients with selected solid cancer: results of “Cancer POP” study
    Wiley ; 2018
    In:  Cancer Medicine Vol. 7, No. 1 ( 2018-01), p. 261-269
    Details
    In: Cancer Medicine, Wiley, Vol. 7, No. 1 ( 2018-01), p. 261-269
    Abstract: The aim of this study was to investigate the incidence and risk factors of postoperative pneumonia ( POP ) within 1 year after cancer surgery in patients with the five most common cancers (gastric, colorectal, lung, breast cancer, and hepatocellular carcinoma [ HCC ]) in South Korea. This was a multicenter and retrospective cohort study performed at five nationwide cancer centers. The number of cancer patients in each center was allocated by the proportion of cancer surgery. Adult pat ients were randomly selected according to the allocated number, among those who underwent cancer surgery from January to December 2014 within 6 months after diagnosis of cancer. One‐year cumulative incidence of POP was estimated using Kaplan–Meier analysis. An univariable Cox's proportional hazard regression analysis was performed to identify risk factors for POP development. As a multivariable analysis, confounders were adjusted using multiple Cox's PH regression model. Among the total 2000 patients, the numbers of patients with gastric cancer, colorectal cancer, lung cancer, breast cancer, and HCC were 497 (25%), 525 (26%), 277 (14%), 552 (28%), and 149 (7%), respectively. Overall, the 1‐year cumulative incidence of POP was 2.0% (95% CI , 1.4–2.6). The 1‐year cumulative incidences in each cancer were as follows: lung 8.0%, gastric 1.8%, colorectal 1.0%, HCC 0.7%, and breast 0.4%. In multivariable analysis, older age, higher Charlson comorbidity index ( CCI ) score, ulcer disease, history of pneumonia, and smoking were related with POP development. In conclusions, the 1‐year cumulative incidence of POP in the five most common cancers was 2%. Older age, higher CCI scores, smoker, ulcer disease, and previous pneumonia history increased the risk of POP development in cancer patients.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2018.7.issue-1
    DOI: 10.1002/cam4.1259
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2659751-2
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  • 8
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    Metabolically healthy versus unhealthy obesity and risk of fibrosis progression in non‐alcoholic fatty liver disease
    Wiley ; 2019
    In:  Liver International Vol. 39, No. 10 ( 2019-10), p. 1884-1894
    Details
    In: Liver International, Wiley, Vol. 39, No. 10 ( 2019-10), p. 1884-1894
    Abstract: Little is known about the impact of metabolically healthy obesity on fibrosis progression in non‐alcoholic fatty liver disease (NAFLD). We investigated the association of body mass index (BMI) category, body fat percentage and waist circumference with worsening of noninvasive fibrosis markers in metabolically healthy and unhealthy individuals with NAFLD. Methods A cohort study was performed on 59 957 Korean adults with NAFLD (13 285 metabolically healthy and 46 672 metabolically unhealthy individuals) who were followed for a median of 7.7 years. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homoeostasis model assessment of insulin resistance 〈 2.5. Progression from low to intermediate or high probability of advanced fibrosis was assessed using the NAFLD fibrosis score (NFS). Results During 339 253.1 person‐years of follow‐up, 9857 subjects with low NFS at baseline progressed to intermediate or high NFS. Among metabolically healthy individuals, the multivariable‐adjusted HRs (95% CI) for NFS worsening comparing BMIs 23‐24.9, 25‐29.9 and ≥30 with a BMI of 18.5‐22.9 kg/m 2 were 1.19 (1.00‐1.42), 1.79 (1.52‐2.10) and 3.52 (2.64‐4.69), respectively, whereas the corresponding HRs (95% CI) in metabolically unhealthy individuals were 1.37 (1.24‐1.52), 2.18 (1.99‐2.39) and 4.26 (3.83‐4.75). A similar trend was observed in the analyses using body fat and waist circumference. Conclusion In the large‐scale cohort of young and middle‐aged individuals with NAFLD, BMI was positively associated with worsening of noninvasive fibrosis marker regardless of metabolic health status. Excess adiposity per se, even without accompanying metabolic health status, may contribute to fibrosis progression in NAFLD.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v39.10
    DOI: 10.1111/liv.14184
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2124684-1
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  • 9
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    A Selective Colorimetric and Fluorometric Chemosensor Based on Conjugated Polydiacetylenes for Cadmium Ion Detection
    Wiley ; 2019
    In:  ChemPhotoChem Vol. 3, No. 11 ( 2019-11), p. 1133-1137
    Details
    In: ChemPhotoChem, Wiley, Vol. 3, No. 11 ( 2019-11), p. 1133-1137
    Abstract: In the current study, a polydiacetylene (PDA)‐based sensor, derived from a chelidamic acid‐picolylamine (CP)‐substituted diacetylene monomer, displayed a selective colorimetric and fluorometric change in the presence of cadmium (Cd 2+ ) at pH 7.4. The PDA−CP solutions showed a colorimetric change from blue to violet in response to various amounts of Cd 2+ . The chemosensor also showed a rapid fluorescence turn‐on response and significant selectivity to Cd 2+ compared with other metallic cations. The Cd 2+ ‐selective PDA‐based sensor system facilitated the visual detection of Cd 2+ in aqueous solution. The Cd 2+ detection limit of PDA−CP was reduced to 1.85×10 −5  M.
    Type of Medium: Online Resource
    ISSN: 2367-0932 , 2367-0932
    URL: Issue
    URL: Article
    DOI: 10.1002/cptc.v3.11
    DOI: 10.1002/cptc.201900165
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2881321-2
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  • 10
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    Clinical Importance of Intraoperative Cephalic Vein Distensibility as a Predictor of Radiocephalic Arteriovenous Fistula Maturation
    Wiley ; 2015
    In:  Seminars in Dialysis Vol. 28, No. 6 ( 2015-11)
    Details
    In: Seminars in Dialysis, Wiley, Vol. 28, No. 6 ( 2015-11)
    Abstract: Radiocephalic arteriovenous fistula ( RCAVF ) is the preferred vascular access, but the maturation failure rate is high. Poor vein distensibility is the main cause of maturation failure. There have been several studies regarding vein distensibility, but vein dilation protocol and the cut‐off value predicting maturation failure were inconsistent. We were doubtful that the vein distensibility had been appropriately evaluated, and sought to determine a more clinically applicable parameter. The cephalic vein was dilated via intraluminal hydrostatic pressure during the surgery and the vein size was measured. Maturation failure occurred in 30 patients (22.4%) and was more common in females and in patients who had a previous history of arteriovenous access formation ( p  =   0.0095 and p  =   0.014). The intraoperative postdilation diameter, and the difference between pre and postdilation diameters differed between the two groups ( p  = 0.0004 and p  = 0.0004). The cut‐off value of the postdilation diameter, which indicated a high probability of maturation success, was 〉 4 mm, and the cut‐off value which indicated a higher probability of maturation failure; that is, the difference between the pre and postdilation diameter, was ≤2.2 mm. The degree of distensibility of the cephalic vein may be an important determinant of RCAVF maturation.
    Type of Medium: Online Resource
    ISSN: 0894-0959 , 1525-139X
    URL: Issue
    URL: Article
    DOI: 10.1111/sdi.2015.28.issue-6
    DOI: 10.1111/sdi.12452
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2010756-0
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