In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-27), p. e0262906-
Abstract:
Diet and exercise can alter the gut microbiota, but recent studies have assessed the impact of athletic competition on gut microbiota and host metabolites. We designed an open-label pilot study to investigate the effects of both official competition and a multi-strain lactic acid bacteria-fermented soymilk extract (LEX) on the gut microbiota in Japanese college endurance athletes. The analysis of fecal 16S rRNA metagenome and urinary metabolites was used to identify changes in gut microbiota composition and host metabolism. When the fecal microbiota were investigated before and after a race without using of a supplement (pre-observation period), there was an increase in the phylum Firmicutes and decrease in Bacteroidetes . However, no changes in these phyla were seen before and after a race in those who consumed LEX. Before and after LEX ingestion, changes in urinary metabolites included a significant reduction in yeast and fungal markers, neurotransmitters, and mitochondrial metabolites including the TCA cycle. There were several correlations between urinary metabolites and the composition of fecal microbiota. For example, the level of tricarballylic acid was positively correlated with the composition ratio of phylum Firmicutes (Pearson’s r = 0.66; p 〈 0.01). The bacterial species Parabacteroides distasonis was also found to correlate moderately with several urinary metabolites. These findings suggest two possibilities. First, endurance athletes experience significant fluctuations in gut microbiota after a single competition. Second, LEX ingestion may improve yeast and fungal overgrowth in the gastrointestinal tract and enhancing mitochondrial metabolic function.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0262906
DOI:
10.1371/journal.pone.0262906.g001
DOI:
10.1371/journal.pone.0262906.g002
DOI:
10.1371/journal.pone.0262906.g003
DOI:
10.1371/journal.pone.0262906.g004
DOI:
10.1371/journal.pone.0262906.g005
DOI:
10.1371/journal.pone.0262906.t001
DOI:
10.1371/journal.pone.0262906.s001
DOI:
10.1371/journal.pone.0262906.s002
DOI:
10.1371/journal.pone.0262906.s003
DOI:
10.1371/journal.pone.0262906.s004
DOI:
10.1371/journal.pone.0262906.s005
DOI:
10.1371/journal.pone.0262906.s006
DOI:
10.1371/journal.pone.0262906.s007
DOI:
10.1371/journal.pone.0262906.s008
DOI:
10.1371/journal.pone.0262906.r001
DOI:
10.1371/journal.pone.0262906.r002
DOI:
10.1371/journal.pone.0262906.r003
DOI:
10.1371/journal.pone.0262906.r004
DOI:
10.1371/journal.pone.0262906.r005
DOI:
10.1371/journal.pone.0262906.r006
DOI:
10.1371/journal.pone.0262906.r007
DOI:
10.1371/journal.pone.0262906.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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