In:
FEBS Letters, Wiley, Vol. 507, No. 3 ( 2001-11-02), p. 377-380
Abstract:
Reactive oxygen species (ROS) primarily arise from products of normal metabolic activities and are thought to be the etiology of many diseases. A novel dicyclodextrinyl ditelluride (2‐TeCD) compound was designed to be a functional mimic of the glutathione peroxidase that normally removes ROS. 2‐TeCD exhibited highly catalytic efficiency and good water solubility. Antioxidant activity was studied by using ferrous sulfate/ascorbate‐induced mitochondria damage model system. 2‐TeCD protected the mitochondria against oxidative damage in a dose‐dependent manner and exhibited also great antioxidant ability in comparison with 2‐phenyl‐1,2‐benziososelenazol‐3(2H)‐one. The mimic may result in better clinical therapies for the treatment of ROS‐mediated diseases.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)03011-3
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
1460391-3
SSG:
12
Permalink