In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2021-11-18), p. e0256676-
Abstract:
Understanding implications of passive smoke exposure during pregnancy is an important public health issue under the Developmental Origins of Health and Disease paradigm. In a prospective cohort of low-risk non-smoking pregnant women (NICHD Fetal Growth Studies—Singletons, 2009–2013, N = 2055), the association between first trimester passive smoke exposure and neonatal size was assessed by race/ethnicity. Plasma biomarker concentrations (cotinine, nicotine) assessed passive smoke exposure. Neonatal anthropometric measures included weight, 8 non-skeletal, and 2 skeletal measures. Linear regression evaluated associations between continuous biomarker concentrations and neonatal anthropometric measures by race/ethnicity. Cotinine concentrations were low and the percent above limit of quantification varied by maternal race/ethnicity (10% Whites; 14% Asians; 15% Hispanics; 49% Blacks). The association between cotinine concentration and infant weight differed by race/ethnicity (P interaction = 0.034); compared to women of the same race/ethnicity, per 1 log-unit increase in cotinine, weight increased 48g (95%CI -44, 139) in White and 51g (95%CI -81, 183) in Hispanic women, but decreased -90g (95%CI -490, 309) in Asian and -93g (95%CI -151, -35) in Black women. Consistent racial/ethnic differences and patterns were found for associations between biomarker concentrations and multiple non-skeletal measures for White and Black women (P interaction 〈 0.1). Among Black women, an inverse association between cotinine concentration and head circumference was observed (−0.20g; 95%CI −0.38, −0.02). Associations between plasma cotinine concentration and neonatal size differed by maternal race/ethnicity, with increasing concentrations associated with decreasing infant size among Black women, who had the greatest biomarker concentrations. Public health campaigns should advocate for reducing pregnancy exposure, particularly for vulnerable populations.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0256676
DOI:
10.1371/journal.pone.0256676.g001
DOI:
10.1371/journal.pone.0256676.g002
DOI:
10.1371/journal.pone.0256676.t001
DOI:
10.1371/journal.pone.0256676.t002
DOI:
10.1371/journal.pone.0256676.s001
DOI:
10.1371/journal.pone.0256676.s002
DOI:
10.1371/journal.pone.0256676.s003
DOI:
10.1371/journal.pone.0256676.s004
DOI:
10.1371/journal.pone.0256676.s005
DOI:
10.1371/journal.pone.0256676.s006
DOI:
10.1371/journal.pone.0256676.s007
DOI:
10.1371/journal.pone.0256676.s008
DOI:
10.1371/journal.pone.0256676.s009
DOI:
10.1371/journal.pone.0256676.s010
DOI:
10.1371/journal.pone.0256676.s011
DOI:
10.1371/journal.pone.0256676.r001
DOI:
10.1371/journal.pone.0256676.r002
DOI:
10.1371/journal.pone.0256676.r003
DOI:
10.1371/journal.pone.0256676.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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