In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-1), p. e0278610-
Abstract:
Pulmonary arteriovenous malformation (PAVM) is a rare pulmonary disease. Although most patients with PAVMs are asymptomatic, cerebral complications associated with PAVMs are often fatal. This study aimed to evaluate the risk factors for cerebral complications in patients with PAVMs. Methods We retrospectively reviewed the medical charts of patients with PAVMs between 2003 and 2021 at two tertiary referral hospitals and one secondary hospital. Results Fifty-five patients diagnosed with PAVMs were enrolled in this study. Most patients were female (89.1%), and the median age was 53 years. Thirty patients (54.5%) had incidentally detected PAVMs without symptoms. Twenty-four patients (43.7%) with PAVMs were treated with embolotherapy or surgery. Thirteen patients (23.6%) had cerebral complications. There was no significant difference in the development of cerebral complications according to treatment; however, older age (≥ 65 years) was associated with the development of new cerebral complications in untreated patients with PAVMs (odds ratio, 17.09; 95% confidence interval, 1.16–250.31; P = 0.038). Conclusion Older age (≥ 65 years) was a risk factor for the development of cerebral complications in patients with PAVMs; therefore, treatment should be considered in older patients with PAVMs.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0278610
DOI:
10.1371/journal.pone.0278610.g001
DOI:
10.1371/journal.pone.0278610.g002
DOI:
10.1371/journal.pone.0278610.g003
DOI:
10.1371/journal.pone.0278610.t001
DOI:
10.1371/journal.pone.0278610.t002
DOI:
10.1371/journal.pone.0278610.t003
DOI:
10.1371/journal.pone.0278610.s001
DOI:
10.1371/journal.pone.0278610.s002
DOI:
10.1371/journal.pone.0278610.s003
DOI:
10.1371/journal.pone.0278610.s004
DOI:
10.1371/journal.pone.0278610.s005
DOI:
10.1371/journal.pone.0278610.r001
DOI:
10.1371/journal.pone.0278610.r002
DOI:
10.1371/journal.pone.0278610.r003
DOI:
10.1371/journal.pone.0278610.r004
DOI:
10.1371/journal.pone.0278610.r005
DOI:
10.1371/journal.pone.0278610.r006
DOI:
10.1371/journal.pone.0278610.r007
DOI:
10.1371/journal.pone.0278610.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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