In:
Molecular Carcinogenesis, Wiley, Vol. 52, No. S1 ( 2013-11), p. 39-51
Abstract:
We investigated whether four common microRNA polymorphisms ( miR‐146a C 〉 G [rs2910164], miR‐149 T 〉 C [rs2292832], miR‐196a2 T 〉 C [rs11614913], and miR‐499 A 〉 G [rs3746444]) are associated with the susceptibility and prognosis of gastric cancer in the Korean population. The four microRNA single‐nucleotide polymorphisms (SNPs) were identified in a case–control study (461 patients; 447 controls) by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis in the Korean population. When patients were stratified into diffuse and intestinal‐type gastric cancer groups, subjects with the miR‐499 AG and AG + GG genotypes had reduced adjusted odds ratios (AORs) for diffuse‐type gastric cancer (AOR = 0.54 with 95% confidence interval [CI] = 0.31–0.97; AOR = 0.57 with 95% CI = 0.33–0.97). In the stratified analyses for gastric cancer risk, the miR‐146a GG and CG + GG genotypes were associated with increased risk of gastric cancers among the non‐smokers, whereas the miR‐149 TC and TC + CC genotypes showed lower risk of gastric cancer in males. The miR‐196a2 CC genotype was associated with elevated gastric cancer risk among females. For gastric cancer prognosis, intestinal‐type gastric cancer patients with miR‐146a CG + GG genotypes had significantly higher survival rates (log‐rank P = 0.030) than patients with the CC genotype, and patients with the miR‐499 AA genotype had significantly increased survival rates compared to patients with the AG + GG genotypes (log‐rank P = 0.013). When miR‐146a CG + GG and miR‐499 AA genotypes were combined, the survival rate of intestinal‐type gastric cancer patients was elevated (log‐rank P 〈 0.001). No association was found between gastric or diffuse‐type cancer prognosis and other miRNAs. Our data demonstrate that specific miRNA SNPs are associated with gastric cancer susceptibility ( miR‐499 A 〉 G) and prognosis ( miR‐146a C 〉 G and miR‐499 A 〉 G) in the Korean population depending on gastric cancer type. © 2012 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0899-1987
,
1098-2744
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2001984-1
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