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  • 1
    Online Resource
    Online Resource
    Ferritin thresholds for cardiac and liver hemosiderosis in β-thalassemia patients: a diagnostic accuracy study
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-10-26)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-10-26)
    Abstract: Ferritin is frequently used to screen some dire consequences of iron overload in β-thalassemia patients. The study aimed to define the best cutoff point of ferritin to screen for cardiac and liver hemosiderosis in these cases. This was a registry-based study on β-thalassemia patients living throughout Mazandaran province, Iran ( n  = 1959). In this diagnostic research, the index test was ferritin levels measured by a chemiluminescent immunoassay. As a reference test, T2*-weighted magnetic resonance imaging (T2*-weighted MRI) was applied to determine cardiac and liver hemosiderosis. A cutoff point of 2027 ng/mL for ferritin showed a sensitivity of 50%, specificity 77.4%, PPV 42.1%, and NPV 82.5% for cardiac hemosiderosis (area under curve [AUC] 0.66, 95% CI 0.60–0.71, adjusted odds ratio [OR] 2.05, 95% CI 1.05–4.01). At an optimum cutoff point of 1090 ng/mL, sensitivity 66.7%, specificity 68%, PPV 82.9%, and NPV 46.8% for liver hemosiderosis were estimated (AUC 0.68, 95% CI 0.63–0.73, adjusted OR 3.93, 95% CI 2.02–7.64. The likelihood of cardiac hemosiderosis serum ferritin levels below 2027 ng/mL is 17.5%. Moreover, 82.9% of β-thalassemia patients with serum ferritin levels above 1090 ng/mL may suffer from liver hemosiderosis, regardless of the grades.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-22234-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 2
    Online Resource
    Online Resource
    Glycemic Fluctuations of Children and Adolescence Type 1 Diabetes Mellitus and the Impressive Aspects of SARS-CoV-2 Since the Onset of Pandemic Lockdown: A Review Paper
    Negah Scientific Publisher ; 2023
    In:  Journal of Pediatrics Review Vol. 11, No. 2 ( 2023-04-01), p. 135-152
    Details
    In: Journal of Pediatrics Review, Negah Scientific Publisher, Vol. 11, No. 2 ( 2023-04-01), p. 135-152
    Abstract: Background: The COVID-19 pandemic limited the daily activities of children and adolescents with type 1 diabetes mellitus, and several factors are impacting ongoing care. The role of pandemics on glycemic control is unknown. We plan to assess the glycemic status and the factors that influence it during the pandemic. Objectives: Our goal was to examine the impact of COVID-19 quarantine on the glycemic control of children and adolescents with type 1 diabetes mellitus. Methods: Databases including PubMed, Scopus, Web of Science, and Science Direct, with English-type articles extracted from December 31, 2019, to March 3, 2022, were searched. The article review was based on factors influencing glycemic control in type 1 diabetes mellitus cases younger than 18 years of age during the pandemic period such as psychological factors, telemedicine role, lifestyle changes, various diabetes technology (cost, availability…), caregivers’ role, and socioeconomic factors. Results: We scanned 573 articles as an initial search for titles/abstracts and full-text reviews, and 54 articles remained after title/abstract screening for full-text assessment among which 14 articles (cohort studies) were included. Most studies reported glycemic improvement based on blood glucose metrics while some studies reported stable glycemic control. Although the pre-pandemic glucose profile is important, factors such as telemedicine, diabetes technology, and lifestyle play a more tangible role in improving glycemic control during the pandemic. Conclusions: Overall, the studies did not contain strong evidence that glycemic control worsened in children and adolescents with type 1 diabetes mellitus during the pandemic. Although the assessment was conducted over a short period, long-term multicenter studies would be useful for a more precise assessment of the mentioned potential factors.
    Type of Medium: Online Resource
    ISSN: 2322-4398 , 2322-4401
    URL: Journal
    URL: Article
    DOI: 10.32598/jpr
    DOI: 10.32598/jpr.11.2.1073.2
    Language: Unknown
    Publisher: Negah Scientific Publisher
    Publication Date: 2023
    detail.hit.zdb_id: 2885448-2
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  • 3
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    Online Resource
    Significance of CD34-Positive Cells in Children with B-Cell Acute Lymphoblastic Leukemia: A Case-Control Study
    Knowledge E DMCC ; 2024
    In:  Iranian Journal of Pediatric Hematology & Oncology ( 2024-01-09)
    Details
    In: Iranian Journal of Pediatric Hematology & Oncology, Knowledge E DMCC, ( 2024-01-09)
    Abstract: Background: Acute lymphoblastic leukemia (ALL) is the most common cancer among children. The prognostic significance of the cluster of differentiation 34 (CD34) markers in children with B-cell acute lymphoblastic leukemia (B-ALL) is not yet fully understood. Materials and Methods: This study is a case-control trial based on the clinical data of 40 children with B-ALL who referred to a pediatric oncology center in the city of Sari, Iran. The data were derived from the demographic findings, laboratory test results at diagnosis, immunophenotyping, transfusion of blood products including packed red blood cells and platelet concentrates, and the frequency and duration of hospitalization due to febrile infection. Results: Of the participants, 42.5% were CD34-negative and 57.5% were CD34-positive. The mean age of the patients at diagnosis was 3.1 ± 3.3 years (Range:0.1-13.3 years). Also, 60.9% of the CD34-positive children and 47.1% of the CD34-negative ones were boys (P = 0.38). According to the calculated Cohen's d, the relationship of CD34 positivity with transfused packed red blood cell and platelet concentrates was mild -0.15 (95% CI -0.78 to 0.47) (P = 0.55) and moderate 0.49 (95% CI -0.15 to 1.12) (P = 0.29), respectively, which was significant in neither case. Moreover, the relationship of CD34 positivity with the hospitalization frequency of -0.51 (95% CI -1.14 to 0.13) (P = 0.22) and the hospitalization duration of -0.52 (95% CI -1.16 to 0.12) (P = 0.27) due to febrile infection was moderate to strong. Conclusion: The CD34-positive children with B-ALL experienced less blood products transfusion (except packed red blood cells) and febrile infection in terms of both the frequency and duration of hospitalization during chemotherapy. Therefore, CD34 expression in the B-ALL children was associated with better prognosis.
    Type of Medium: Online Resource
    ISSN: 2008-8892
    URL: Article
    DOI: 10.18502/ijpho.v14i1.14660
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2024
    detail.hit.zdb_id: 2628613-0
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  • 4
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    Online Resource
    Relationship between medical history and multiple sclerosis: A-case-control study
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Medicine Vol. 102, No. 23 ( 2023-06-09), p. e33906-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 102, No. 23 ( 2023-06-09), p. e33906-
    Abstract: This project sought to explore the potential association between medical history and the development of multiple sclerosis (MS) by conducting a retrospective study. This population-based case-control study included 200 MS cases and 2 control groups of 200 patients and healthy individuals each. Data was collected through face-to-face interviews, medical file reviews, and an electronic checklist. Multivariable analysis was used to calculate odds ratios and 95% confidence intervals to estimate the risk of each medical history on MS occurrences. Of 600 participants, 381 (63.5%) individuals were female. The mean age of the participants was 36.5 ± 11.9 years. The adjusted risks of MS were 4.40; 95% CI: 1.73 to 11.1 for measles and 4.75; 95% CI: 2.05 to 11 for amoxicillin consumption. The adjusted MS odds for autoimmune disease including 4.63; 95% CI: 0.35 to 60.6 for psoriasis and 7.15; 95% CI: 1.87 to 27.2 for myasthenia gravis. On the other hand, the calculated adjusted odds of MS occurrence were 0.14; 95% CI: 0.03 to 0.69 for seizure and 0.17; 95% CI: 0.02 to 1.49 for epilepsy. This study suggested that individuals with autoimmune diseases should be monitored more closely, as they may be at an increased risk of developing other autoimmune conditions, particularly MS.
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000033906
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2049818-4
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  • 5
    Online Resource
    Online Resource
    Variation of Newly Diagnosed Type 1 Diabetes Mellitus Cases During Covid-19 Pandemic: A Review
    Negah Scientific Publisher ; 2023
    In:  Journal of Pediatrics Review Vol. 11, No. 1 ( 2023-01-01), p. 37-46
    Details
    In: Journal of Pediatrics Review, Negah Scientific Publisher, Vol. 11, No. 1 ( 2023-01-01), p. 37-46
    Abstract: Background Type 1 diabetes mellitus (T1DM) is one of the chronic diseases that timely and correct management affects the outcome of these patients. COVID-19 is an acute respiratory infection that has created a disproportionate situation for individuals and healthcare systems. The resulting pandemic is associated with delayed presentation of patients as well as increased frequency and severity of acute complications. Objectives This review study aims to investigate the incidence, initial presentation, frequency, and severity of diabetic ketoacidosis (DKA) as well as changes in demographic findings, such as age and sex in newly diagnosed T1DM children and adolescents during the COVID-19 pandemic. Methods The search was conducted in different databases, using the keywords: T1DM, COVID-19, pediatrics, and incidence to find the related articles published in English from December 31, 2019, to March 3, 2022. Results There is no clear evidence for increase in the incidence of T1DM and the frequency and severity of DKA in female and younger people during the pandemic compared to the pre-pandemic period. Further studies with larger sample sizes are needed to better understand the role of pandemic on disease incidence and acute complications. Conclusions: To reduce the incidence of DKA and speed up the diagnosis of T1DM during the pandemic, people should be informed about their symptoms.
    Type of Medium: Online Resource
    ISSN: 2322-4398 , 2322-4401
    URL: Journal
    URL: Article
    DOI: 10.32598/jpr
    DOI: 10.32598/jpr.11.1.1073.1
    Language: Unknown
    Publisher: Negah Scientific Publisher
    Publication Date: 2023
    detail.hit.zdb_id: 2885448-2
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  • 6
    Online Resource
    Online Resource
    Pancytopenia as a Presentation of Iron Deficiency: A Case Report
    Negah Scientific Publisher ; 2021
    In:  Journal of Pediatrics Review Vol. 9, No. 2 ( 2021-04-01), p. 159-162
    Details
    In: Journal of Pediatrics Review, Negah Scientific Publisher, Vol. 9, No. 2 ( 2021-04-01), p. 159-162
    Abstract: One of the most common nutritional deficiencies worldwide is iron deficiency. Fatigue, pallor, vertigo, dyspnea, cold intolerance, lethargy, palpitation, headache, and the pallor of the mucous membranes or nail beds are the most frequent symptoms and signs of iron deficiency. Thrombocytosis is commonly observed in iron deficiency anemia; it seems that erythropoietin plays the main role in this respect. Furthermore, thrombocytopenia and even leukopenia have been reported in iron deficiency; however, pancytopenia is a very rare condition. In this report, we presented two unusual cases of pancytopenia due to severe iron deficiency that improved after treatment with oral iron supplements. Iron deficiency anemia, if sufficiently severe, may be associated with reduced platelet and leukocyte counts. Accordingly, this condition should be considered as a differential diagnosis in all patients with pancytopenia.
    Type of Medium: Online Resource
    ISSN: 2322-4398 , 2322-4401
    URL: Journal
    URL: Article
    DOI: 10.32598/jpr
    DOI: 10.32598/jpr.9.2.786.2
    Language: Unknown
    Publisher: Negah Scientific Publisher
    Publication Date: 2021
    detail.hit.zdb_id: 2885448-2
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  • 7
    Online Resource
    Online Resource
    Factors Related to Reduced Bone Density in β-Thalassemia Major Patients: Mazandaran Thalassemia Registry
    Knowledge E DMCC ; 2023
    In:  Journal of Shahid Sadoughi University of Medical Sciences ( 2023-08-27)
    Details
    In: Journal of Shahid Sadoughi University of Medical Sciences, Knowledge E DMCC, ( 2023-08-27)
    Abstract: Introduction: OsteoPenia and osteoPorosis are known to be one of the main comPlications of β-thalassemia major (β-TM). The aim of this study was to determine the factors associated with decreased bone density of these Patients. Methods: Lumbar and femoral neck bone mineral density (BMD) in β-TM Patients characterized via Dual-energy X-ray absorPtiometry (DXA) to PinPoint the association of iron chelators, diabetes mellitus, serum ferritin above 3000 ng/mL, hemoglobin below 8 gr/dl, using hydroxyurea, liver siderosis and moderate to severe hePatic and cardiac siderosis with BMD. The information was collected from the thalassemia registry in 2019 and statistical analysis was Performed by STATA-13 software. Results: Out of 1959 ParticiPants with β-thalassemia major registered in the registry, 139 ones (7.09%) had bone mineral density (53 males and 86 females). The Prevalence of abnormal bone density in the lumbar and femoral neck was (52.48 to 47.66) 57.5 and (40.18 to 57.52) 48.85 Percent, resPectively. After adjusting for the effects of Possible interventions, the odds ratio of abnormal bone density in the Patients consuming hydroxyurea and deferasirox were 0.24 (0.03 to 1.73) and 0.25 (0.03 to 1.69), resPectively. The highest odds were 8.21 (0.18 to 360.22), and 6.72 (0.60 to 74.83) for moderate to severe cardiac and hePatic dePosition, resPectively. Conclusion: The Prevalence of osteoPenia and osteoPorosis is high among thalassemia major Patients. ConsumPtion of hydroxyurea and deferasirox is the most imPortant Protective factor and moderate to severe cardiac and hePatic siderosis are the most imPortant risk factors for abnormal bone density.
    Type of Medium: Online Resource
    ISSN: 2228-5733 , 2228-5741
    URL: Article
    DOI: 10.18502/ssu.v31i6.13473
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2023
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