In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-14), p. e0243780-
Abstract:
The purpose of this study was to investigate the effect of acute kidney injury (AKI) on the prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). A total of 347 HCC patients with Child-Pugh class A and pre-TACE serum creatinine (SCr) ≤1.5 mg/dL undergoing TACE as an initial therapy 2000–2014 were analyzed. Overall survival with related risk factors including AKI was investigated. We assessed AKI based on the International Club of Ascites (ICA)-AKI criteria. The mean age was 60.9 years. Of 347 patients, death was observed in 109 patients (31.4%). The mean SCr levels at pre-TACE, one day, two months, and four months after TACE were 0.9, 0.9, 0.9, and 1.1 mg/dL, respectively. The AKI within four months after TACE developed in 37 patients (11%). The AKI stages were non-AKI in 310 (89%), stage 1 in 10 (3%), stage 2 in 10 (3%), and stage 3 in 17 patients (5%). Multivariable analysis showed that the risk factors for overall survival were serum albumin ≤3.5 g/dL (hazard ratio [HR] 1.58, p = 0.027), BCLC stage B (HR 2.07, p = 0.008), BCLC stage C (HR 3.96, p 〈 0.001), bilobar tumor location (HR 1.66, p = 0.022), AKI stage 1 (HR 6.09, p 〈 0.001), AKI stage 2 (HR 8.51, p 〈 0.001), and AKI stage 3 (HR 17.64, p 〈 0.001). AKI is a crucial prognostic factor for overall survival in HCC patients undergoing TACE. The assessment of AKI based on the ICA-AKI criteria can facilitate evaluation of the prognosis of HCC patients undergoing TACE.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0243780
DOI:
10.1371/journal.pone.0243780.g001
DOI:
10.1371/journal.pone.0243780.g002
DOI:
10.1371/journal.pone.0243780.t001
DOI:
10.1371/journal.pone.0243780.t002
DOI:
10.1371/journal.pone.0243780.t003
DOI:
10.1371/journal.pone.0243780.t004
DOI:
10.1371/journal.pone.0243780.s001
DOI:
10.1371/journal.pone.0243780.s002
DOI:
10.1371/journal.pone.0243780.r001
DOI:
10.1371/journal.pone.0243780.r002
DOI:
10.1371/journal.pone.0243780.r003
DOI:
10.1371/journal.pone.0243780.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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