In:
Alzheimer's & Dementia, Wiley, Vol. 16, No. 6 ( 2020-06), p. 831-842
Abstract:
The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function. Methods Observational analyses of participants (n = 7,756) enrolled in two randomized trials of nutritional supplements for age‐related macular degeneration: Age‐Related Eye Disease Study (AREDS) and AREDS2. Results Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 ( P = .0001) for Modified Mini‐Mental State ( 〈 80) and 0.56 ( P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status‐Modified ( 〈 30) and 0.48 for composite score (each P 〈 .0001) in AREDS2. Fish intake was associated with higher cognitive function. In AREDS2, rate of cognitive decline over 5 to 10 years was not significantly different by aMED but was significantly slower ( P = .019) with higher fish intake. Discussion Closer Mediterranean diet adherence was associated with lower risk of cognitive impairment but not slower decline in cognitive function. Apolipoprotein E ( APOE ) haplotype did not influence these relationships.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2201940-6
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