In:
Journal of Pharmacy Technology, SAGE Publications, Vol. 11, No. 2 ( 1995-03), p. 53-54
Abstract:
To report a case of myocardial infarction with patent coronary arteries and left ventricular outflow obstruction induced by a combination of aminophylline and beta 2 -agonists treatment. Case Summary: A 61-year-old woman, without risk factors for coronary artery disease, was admitted with an exacerbation of bronchial asthma. She received intravenous aminophylline and aerosolized beta 2 -agonists. She developed hemodynamic and echocardiographic features of obstructive hypertrophic cardiomyopathy and had a myocardial infarction. Her serum theophylline concentration was normal. At cardiac catheterization the coronary arteries were patent and the obstructive features disappeared when the asthma drug treatment was discontinued. Discussion: This case describes the occurrence of a very unusual combination of cardiovascular adverse effects induced by drugs widely used for treatment of bronchial asthma. Aminophylline and beta 2 -agonists can cause myocardial ischemia by inducing tachycardia, hypercontractility, and coronary artery spasm. Conclusions: Aminophylline and beta 2 -agonists can induce severe and life-threatening myocardial ischemia, even when used at therapeutic drug concentrations.
Type of Medium:
Online Resource
ISSN:
8755-1225
,
1549-4810
DOI:
10.1177/875512259501100209
Language:
English
Publisher:
SAGE Publications
Publication Date:
1995
detail.hit.zdb_id:
2411329-3
SSG:
15,3
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