In:
Tropical Journal of Pharmaceutical Research, African Journals Online (AJOL), Vol. 18, No. 6 ( 2021-05-27), p. 1155-1160
Abstract:
Purpose: To investigate the dissolution properties of various brands of naproxen in four dissolution media in order to forecast their biological availability. Methods: Dissolution tests were carried out in a dissolution tester with 48 tablets of different naproxen brands in 900 mL of 0.1 M phosphate buffer, pH 7.4. Subsequently, the medium was modified with 600 mL of buffer plus 300 mL of cola drink, grapefruit or milk. Each sample was taken and brought to a concentration approximating that of a reference solution. Absorbance at 332 nm was determined and the dissolution, Q, was calculated (Q values ≥ 80.0 ± 5 % were acceptable). Results: Dissolution in buffer was 〉 85 %. In cola drink, it was 〈 80 %, while in grapefruit juice, it was in the range of 7 - 68 %. Using 2-way ANOVA, these media and the three naproxen brands showed significant differences (F = 68.90, p = 0.0000; F = 23.18, p = 0.0000). With Fisher's LSD test, two of these media contributed consistently to dissolution, and the three drug brands showed statistically different dissolution profiles (p ≤ 0.05). Conclusion: Caution must be exercised cola drink, grapefruit juice and milk are used to administered naproxen as the biological availability of the drug may be altered.
Type of Medium:
Online Resource
ISSN:
1596-9827
,
1596-5996
DOI:
10.4314/tjpr.v18i6.1
Language:
Unknown
Publisher:
African Journals Online (AJOL)
Publication Date:
2021
detail.hit.zdb_id:
2125881-8
SSG:
15,3
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