GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (2)
  • Pharmacy  (2)
Material
Publisher
  • Wiley  (2)
Person/Organisation
Language
Years
FID
  • Pharmacy  (2)
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Effects of Matrine on Proliferation and Apoptosis in Gallbladder Carcinoma Cells (GBC‐SD)
    Wiley ; 2012
    In:  Phytotherapy Research Vol. 26, No. 6 ( 2012-06), p. 932-937
    Details
    In: Phytotherapy Research, Wiley, Vol. 26, No. 6 ( 2012-06), p. 932-937
    Abstract: Although matrine, a primary active component of dried Sophora flavescens root (ku shen), is known to induce apoptosis in a variety of tumor cells in vitro , the molecular mechanism of such apoptosis remains elusive. This analysis of the cell cycle and apoptosis in matrine‐treated human gallbladder carcinoma cells (GBC‐SD) showed that matrine can indeed inhibit cell proliferation and induce G1 cell cycle arrest and apoptosis in a dose‐ and time‐dependent manner. An additional western blot analysis of matrine‐treated cells also showed caspase‐3 and Bcl‐2 activation, as well as cyclinE down‐regulation. Overall, the results indicate that matrine perturbs gallbladder cancer cell progression during the G1 phase by down‐regulating cyclinE and induces apoptosis by decreasing the expression of the antiapoptotic protein Bcl‐2 and increasing expression of the proapoptotic protein Bax. Copyright © 2011 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v26.6
    DOI: 10.1002/ptr.3657
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Population pharmacokinetics of polymyxin B in patients with liver dysfunction
    Wiley ; 2023
    In:  British Journal of Clinical Pharmacology
    Details
    In: British Journal of Clinical Pharmacology, Wiley
    Abstract: Polymyxin B (PMB) is widely used to treat infections caused by multidrug‐resistant Gram‐negative pathogens. Currently, the pharmacokinetic data of PMB in patients with liver dysfunction are limited. This study aimed to develop a population pharmacokinetic (PopPK) model of PMB in patients with liver dysfunction and identify the factors affecting PMB pharmacokinetics. Methods We conducted a retrospective pharmacokinetic study involving 136 adults with different levels of liver function. Nonlinear mixed effects modelling was used to develop a PopPK model of PMB. Monte Carlo simulation was used to design PMB dosage schedules across various liver and renal functions. Results PMB pharmacokinetic analyses included 401 steady‐state concentrations in 136 adult patients. A one‐compartment pharmacokinetic model with first‐order absorption and elimination was used to describe the data. The typical population value of PMB clearance was 2.43 L/h and the volume of distribution was 23.11 L. This study revealed that creatinine clearance (CrCL) and Child–Pugh class were significantly associated with PMB pharmacokinetic parameters; however, clinically relevant variations of dose‐normalized drug exposure were not significant. For patients with a minimum inhibitory concentration of ≤0.5 mg/L, the appropriate dose was 40–75 mg/12‐h. When the dose exceeded 100 mg/12‐h, the risk of nephrotoxicity increased significantly. Conclusions This study provided PMB pharmacokinetic information for patients with liver dysfunction. Patients with renal and liver dysfunctions may not require an initial dose adjustment. Rather than PopPK‐guided dose adjustment, therapeutic drug monitoring of PMB plays a more direct role in optimizing dosing regimens based on its therapeutic window.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Article
    DOI: 10.1111/bcp.15855
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...