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  • 1
    Keywords: Hydraulic engineering. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (212 pages)
    Edition: 1st ed.
    ISBN: 9789811029356
    Series Statement: Springer Natural Hazards Series
    DDC: 551
    Language: English
    Note: Intro -- Preface -- Contents -- Notations and Acronyms -- List of Figures -- List of Tables -- 1 Introduction -- Abstract -- 1.1 Background -- 1.1.1 Landslide -- 1.1.2 Earthquake-Induced Landslides -- 1.2 Preventive Countermeasures and Two Major Issues -- 1.3 Scope and Objectives -- 1.4 Monograph Organization -- References -- 2 Review of Studies on Earthquake-Induced Landslides -- Abstract -- 2.1 Introduction -- 2.2 Seismic Slope Stability Analysis -- 2.2.1 Pseudo-Static Methods -- 2.2.1.1 Magnitude -- 2.2.1.2 Direction -- 2.2.1.3 Acting Point -- 2.2.2 Dynamic Sliding Block Methods -- 2.2.2.1 Extensions -- 2.2.2.2 Applications -- 2.2.2.3 Regional Scale Analysis -- 2.2.3 Stress-Strain Methods -- 2.2.3.1 Continuous Methods -- 2.2.3.2 Discontinuous Methods -- 2.3 Landslide Run-Out Analysis -- 2.3.1 Experiment Methods -- 2.3.2 Empirical Methods -- 2.3.2.1 Regression Model-Based Methods -- 2.3.2.2 Geomorphology-Based Methods -- 2.3.3 Analytical Methods -- 2.3.4 Numerical Simulation Methods -- 2.3.4.1 Continuous Methods -- 2.3.4.2 Discontinuous Methods -- 2.4 Comparisons of Various Methods and Conclusions -- References -- 3 Seismic Slope Stability Analysis by Considering Tension Crack -- Abstract -- 3.1 Introduction -- 3.2 Numerical Simulation Method -- 3.2.1 Failure Mechanism in the FLAC3D -- 3.2.2 Dynamic Formulation -- 3.2.2.1 Brief Description of Dynamic Analysis Using FLAC3D -- 3.2.2.2 Modeling with FLAC3D -- 3.2.2.3 Earthquake Loading -- 3.2.3 Results -- 3.2.3.1 Stress and Tension Failure -- 3.2.3.2 FOS Based on Tension-Shear Failure Mechanism -- 3.2.4 Discussions -- 3.2.4.1 Tensile-Shear Failure Mechanism Versus Shear-Only Failure Mechanism -- 3.2.4.2 Shape of Slip Surface -- 3.2.4.3 Progressive Failure -- 3.3 Comparison of Limit Analysis and Numerical Simulation -- 3.3.1 Comparison of the Depth of Tension Failure -- 3.3.2 Comparison of FOS. , 3.3.3 Comparison of the Shape of Slip Surface -- 3.4 Conclusions -- References -- 4 Run-Out Analysis of Earthquake-Induced Landslides -- Abstract -- 4.1 Introduction -- 4.2 Trampoline Effect Induced by Extreme Seismic Loadings -- 4.2.1 Extreme Seismic Loading -- 4.2.2 Trampoline Effect -- 4.2.3 Verification of Trampoline Effect Using DDA -- 4.3 Existing Long Run-Out Models -- 4.3.1 Fluidizations -- 4.3.2 Air Cushion -- 4.3.3 Liquefaction -- 4.4 Multiplex Acceleration Model (MAM) and Extension -- 4.4.1 Single Sliding Model -- 4.4.2 Multi-movement Model -- References -- 5 Extension of Discontinuous Deformation Analysis and Application in Run-Out Analysis of Earthquake-Induced Landslides -- Abstract -- 5.1 Introduction -- 5.2 Theory of DDA -- 5.2.1 Basic Theory and Time Discretization -- 5.2.2 Contact Mechanism -- 5.3 Validation of Static Sliding -- 5.3.1 Limitation of the Original DDA -- 5.3.2 Extension of the Original DDA by Importing Edge-to-Edge Contact -- 5.3.3 Validation of Static Sliding Block -- 5.3.4 Remarks -- 5.4 Validation of Dynamic Block Model -- 5.4.1 Effects of Model Types on the Residual Displacement -- 5.4.2 Effects of Vertical Seismic Force on the Residual Displacement -- 5.4.3 Effects of Model Strike Direction on the Residual Displacement -- 5.4.4 Remarks -- 5.5 Validation of Trampoline Effects -- 5.6 Simulation of the Donghekou Landslide by Using the Developed DDA Program -- 5.6.1 DDA Model, Parameters, and Seismic Loadings -- 5.6.2 Results of DDA Simulation -- 5.7 Conclusions -- References -- 6 A Case Study of Earthquake-Induced Landslide -- Abstract -- 6.1 Introduction -- 6.2 Background Information -- 6.2.1 The Wenchuan Earthquake -- 6.2.2 The Daguangbao Landslide -- 6.2.2.1 Geological Setting -- 6.2.2.2 Failure History -- 6.2.2.3 Failure Type -- 6.3 Material Properties and Ground Motion -- 6.3.1 Material Properties. , 6.3.2 Ground Motion -- 6.3.2.1 Selection of Input Ground Motion -- 6.3.2.2 Baseline Correction -- 6.4 Stability Analysis by the FLAC3D -- 6.4.1 The Finite Difference Method -- 6.4.2 FOS and Strength Reduction Technique -- 6.4.3 Numerical Simulations -- 6.4.3.1 Cases State -- 6.4.3.2 Models -- 6.4.3.3 Boundary Conditions -- 6.4.3.4 Mesh Size -- 6.4.3.5 Mechanical Damping -- 6.4.3.6 Dynamic Loading -- 6.4.4 Results and Discussions of the Stability Analysis -- 6.4.4.1 FoS -- 6.4.4.2 Tension Failure Area -- 6.4.4.3 Permanent Displacements -- 6.5 Run-Out Analysis by the Extended DDA -- 6.5.1 The Seismic DDA Code and Basic Assumptions -- 6.5.2 Geometry and Properties of Sliding Blocks -- 6.5.3 Earthquake Forces -- 6.5.4 Results and Discussions of the Run-out Analysis -- 6.5.4.1 Simulation Results -- 6.5.4.2 Role of the Seismic Loadings on Landslide Run-Out -- 6.5.4.3 Sensitivity Analysis of Shear Strength -- 6.5.4.4 Effects of Topography and 3-D Effects of Block Geometry -- 6.6 Conclusions -- References -- 7 Conclusions and Future Studies -- Abstract -- 7.1 Conclusions -- 7.2 Future Studies -- Appendix A -- Appendix B -- Bibliography.
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  • 2
    Keywords: Earth sciences ; Earth Sciences ; Natural disasters ; Geotechnical engineering ; Geomorphology ; Engineering geology ; Engineering Geology ; Foundations ; Hydraulics
    Description / Table of Contents: This book sheds new light on improved methods for the study of the initiation and run-out of earthquake-induced landslides. It includes an initiation study method considering tension-shear failure mechanism, an improved rigorous dynamic sliding block method based on dynamic critical acceleration and a run-out analysis of earthquake-induced landslide by considering trampoline effect, all of which offer higher accuracy and more convenience to landslide study. The book contains abundant illustrations, figures and tables, which make it appealing for readers to acquire pragmatic tools of landslide research
    Type of Medium: Online Resource
    Pages: Online-Ressource (XXIV, 195 p. 108 illus., 102 illus. in color, online resource)
    ISBN: 9789811029356
    Series Statement: Springer Natural Hazards
    Language: English
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  • 3
    Publication Date: 2013-10-23
    Description: Colorectal cancer (CRC) remains the most common malignancy worldwide. TGF-β1 is often overexpressed in late stages of colorectal carcinogenesis and promotes tumour growth and metastasis. Several reports have verified that the loss of functional TGFBRII expression contributed to escape the tumour suppressor activity of TGF-β1 and that the epithelial-to-mesenchymal transition (EMT) responded to TGF-β1 involved in tumour invasion and metastasis. However, the mechanisms by which TGF-β1 confers a growth advantage to TGFBRII-null colorectal cancer cells have not been elucidated. MicroRNAs (miRNAs) are post-transcriptional inhibitory regulators of gene expression that act by directly binding complementary mRNA and are key determinants of cancer initiation and progression. In this study, we revealed a role for miR-200b in colorectal cancer. MiR-200b was highly expressed in TGFBRII-null tumour tissues and colorectal cancer cell lines and positively correlated with cell proliferation in tumour tissues and cell lines. In contrast, decreasing the miR-200b level in TGFBRII-null cells suppressed cell proliferation and cell cycle progression. Furthermore, in vivo studies also suggested a stimulating effect of miR-200b on TGFBRII-null cell-derived xenografts. CDKN1B (p27/kip1) and RND3 (RhoE) have miR-200b binding sequences within their 3' untranslated regions and were confirmed to be direct targets of miR-200b using fluorescent reporter assays. Meanwhile, CDKN1B (p27/kip1) played a role in miR-200b-stimulated TGFBR-null CRC. This study suggests that miR-200b plays a tumour-promoting role by targeting CDKN1B (p27/kip1) in CRCs. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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